BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

180 related articles for article (PubMed ID: 35164081)

  • 1. Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70.
    O'Connor S; Le Bihan YV; Westwood IM; Liu M; Mak OW; Zazeri G; Povinelli APR; Jones AM; van Montfort R; Reynisson J; Collins I
    Molecules; 2022 Jan; 27(3):. PubMed ID: 35164081
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
    Jones AM; Westwood IM; Osborne JD; Matthews TP; Cheeseman MD; Rowlands MG; Jeganathan F; Burke R; Lee D; Kadi N; Liu M; Richards M; McAndrew C; Yahya N; Dobson SE; Jones K; Workman P; Collins I; van Montfort RL
    Sci Rep; 2016 Oct; 6():34701. PubMed ID: 27708405
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin.
    Moseng MA; Nix JC; Page RC
    FEBS Lett; 2019 Aug; 593(15):2030-2039. PubMed ID: 31177526
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains.
    English CA; Sherman W; Meng W; Gierasch LM
    J Biol Chem; 2017 Sep; 292(36):14765-14774. PubMed ID: 28754691
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain.
    Sriram M; Osipiuk J; Freeman B; Morimoto R; Joachimiak A
    Structure; 1997 Mar; 5(3):403-14. PubMed ID: 9083109
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back.
    Chiappori F; Merelli I; Milanesi L; Colombo G; Morra G
    Sci Rep; 2016 Mar; 6():23474. PubMed ID: 27025773
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Substrate-binding domain conformational dynamics mediate Hsp70 allostery.
    Zhuravleva A; Gierasch LM
    Proc Natl Acad Sci U S A; 2015 Jun; 112(22):E2865-73. PubMed ID: 26038563
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Interdomain communication suppressing high intrinsic ATPase activity of Sse1 is essential for its co-disaggregase activity with Ssa1.
    Kumar V; Peter JJ; Sagar A; Ray A; Jha MP; Rebeaud ME; Tiwari S; Goloubinoff P; Ashish F; Mapa K
    FEBS J; 2020 Feb; 287(4):671-694. PubMed ID: 31423733
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.
    Rodina A; Patel PD; Kang Y; Patel Y; Baaklini I; Wong MJ; Taldone T; Yan P; Yang C; Maharaj R; Gozman A; Patel MR; Patel HJ; Chirico W; Erdjument-Bromage H; Talele TT; Young JC; Chiosis G
    Chem Biol; 2013 Dec; 20(12):1469-80. PubMed ID: 24239008
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance.
    Lai AL; Clerico EM; Blackburn ME; Patel NA; Robinson CV; Borbat PP; Freed JH; Gierasch LM
    J Biol Chem; 2017 May; 292(21):8773-8785. PubMed ID: 28428246
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NMR study of nucleotide-induced changes in the nucleotide binding domain of Thermus thermophilus Hsp70 chaperone DnaK: implications for the allosteric mechanism.
    Revington M; Holder TM; Zuiderweg ER
    J Biol Chem; 2004 Aug; 279(32):33958-67. PubMed ID: 15175340
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.
    Qi R; Sarbeng EB; Liu Q; Le KQ; Xu X; Xu H; Yang J; Wong JL; Vorvis C; Hendrickson WA; Zhou L; Liu Q
    Nat Struct Mol Biol; 2013 Jul; 20(7):900-7. PubMed ID: 23708608
    [TBL] [Abstract][Full Text] [Related]  

  • 13. High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex.
    Taylor IR; Dunyak BM; Komiyama T; Shao H; Ran X; Assimon VA; Kalyanaraman C; Rauch JN; Jacobson MP; Zuiderweg ERP; Gestwicki JE
    J Biol Chem; 2018 Mar; 293(11):4014-4025. PubMed ID: 29414793
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ATP-induced conformational changes in Hsp70: molecular dynamics and experimental validation of an in silico predicted conformation.
    Woo HJ; Jiang J; Lafer EM; Sousa R
    Biochemistry; 2009 Dec; 48(48):11470-7. PubMed ID: 19883127
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket.
    Leu JI; Zhang P; Murphy ME; Marmorstein R; George DL
    ACS Chem Biol; 2014 Nov; 9(11):2508-16. PubMed ID: 25148104
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP.
    Yang J; Nune M; Zong Y; Zhou L; Liu Q
    Structure; 2015 Dec; 23(12):2191-2203. PubMed ID: 26655470
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker.
    Swain JF; Dinler G; Sivendran R; Montgomery DL; Stotz M; Gierasch LM
    Mol Cell; 2007 Apr; 26(1):27-39. PubMed ID: 17434124
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Conformational equilibria in allosteric control of Hsp70 chaperones.
    Wang W; Liu Q; Liu Q; Hendrickson WA
    Mol Cell; 2021 Oct; 81(19):3919-3933.e7. PubMed ID: 34453889
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Probing Allosteric Inhibition Mechanisms of the Hsp70 Chaperone Proteins Using Molecular Dynamics Simulations and Analysis of the Residue Interaction Networks.
    Stetz G; Verkhivker GM
    J Chem Inf Model; 2016 Aug; 56(8):1490-517. PubMed ID: 27447295
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones.
    Zhuravleva A; Gierasch LM
    Proc Natl Acad Sci U S A; 2011 Apr; 108(17):6987-92. PubMed ID: 21482798
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.