These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis. Ferrarini MG; Nisimura LM; Girard RMBM; Alencar MB; Fragoso MSI; Araújo-Silva CA; Veiga AA; Abud APR; Nardelli SC; Vommaro RC; Silber AM; France-Sagot M; Ávila AR mSphere; 2021 Jan; 6(1):. PubMed ID: 33408226 [TBL] [Abstract][Full Text] [Related]
4. PDK inhibition promotes glucose utilization, reduces hepatic lipid deposition, and improves oxidative stress in largemouth bass (Micropterus salmoides) by increasing pyruvate oxidative phosphorylation. Jin AH; Qian YF; Ren J; Wang JG; Qiao F; Zhang ML; Du ZY; Luo Y Fish Shellfish Immunol; 2023 Sep; 140():108969. PubMed ID: 37488039 [TBL] [Abstract][Full Text] [Related]
5. High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Hanberry BS; Berger R; Zastre JA Cancer Chemother Pharmacol; 2014 Mar; 73(3):585-94. PubMed ID: 24452394 [TBL] [Abstract][Full Text] [Related]
6. Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α. Škorja Milić N; Dolinar K; Miš K; Matkovič U; Bizjak M; Pavlin M; Podbregar M; Pirkmajer S Int J Mol Sci; 2021 Aug; 22(16):. PubMed ID: 34445316 [TBL] [Abstract][Full Text] [Related]
7. Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities. Tiersma JF; Evers B; Bakker BM; Jalving M; de Jong S Int J Mol Sci; 2022 Mar; 23(7):. PubMed ID: 35409102 [TBL] [Abstract][Full Text] [Related]
8. Glucose kinetics and pyruvate dehydrogenase activity in septic rats treated with dichloroacetate. Lang CH; Bagby GJ; Blakesley HL; Spitzer JJ Circ Shock; 1987; 23(2):131-41. PubMed ID: 3315289 [TBL] [Abstract][Full Text] [Related]
9. The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury. Kho AR; Choi BY; Lee SH; Hong DK; Jeong JH; Kang BS; Kang DH; Park KH; Park JB; Suh SW Cells; 2019 May; 8(5):. PubMed ID: 31052436 [TBL] [Abstract][Full Text] [Related]
10. Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer. Nunes-Xavier CE; Mingo J; Emaldi M; Flem-Karlsen K; Mælandsmo GM; Fodstad Ø; Llarena R; López JI; Pulido R Front Oncol; 2022; 12():873516. PubMed ID: 35692804 [TBL] [Abstract][Full Text] [Related]
11. Functional response of the isolated, perfused normoxic heart to pyruvate dehydrogenase activation by dichloroacetate and pyruvate. Jaimes R; Kuzmiak-Glancy S; Brooks DM; Swift LM; Posnack NG; Kay MW Pflugers Arch; 2016 Jan; 468(1):131-142. PubMed ID: 26142699 [TBL] [Abstract][Full Text] [Related]
12. Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart. Matsuhashi T; Hishiki T; Zhou H; Ono T; Kaneda R; Iso T; Yamaguchi A; Endo J; Katsumata Y; Atsushi A; Yamamoto T; Shirakawa K; Yan X; Shinmura K; Suematsu M; Fukuda K; Sano M J Mol Cell Cardiol; 2015 May; 82():116-24. PubMed ID: 25744081 [TBL] [Abstract][Full Text] [Related]
13. Pyruvate dehydrogenase activity and malonyl CoA levels in normal and ischemic swine myocardium: effects of dichloroacetate. Stanley WC; Hernandez LA; Spires D; Bringas J; Wallace S; McCormack JG J Mol Cell Cardiol; 1996 May; 28(5):905-14. PubMed ID: 8762030 [TBL] [Abstract][Full Text] [Related]
14. Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. Jha MK; Song GJ; Lee MG; Jeoung NH; Go Y; Harris RA; Park DH; Kook H; Lee IK; Suk K J Neurosci; 2015 Oct; 35(42):14353-69. PubMed ID: 26490872 [TBL] [Abstract][Full Text] [Related]
15. Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation. Kumar A; Kant S; Singh SM Toxicol Appl Pharmacol; 2013 Nov; 273(1):196-208. PubMed ID: 24051182 [TBL] [Abstract][Full Text] [Related]
16. Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target. Hur H; Xuan Y; Kim YB; Lee G; Shim W; Yun J; Ham IH; Han SU Int J Oncol; 2013 Jan; 42(1):44-54. PubMed ID: 23135628 [TBL] [Abstract][Full Text] [Related]
17. Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. Ho N; Coomber BL Exp Cell Res; 2015 Feb; 331(1):73-81. PubMed ID: 25536473 [TBL] [Abstract][Full Text] [Related]
18. Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors. Zhang W; Hu X; Zhou W; Tam KY J Proteome Res; 2018 Sep; 17(9):3012-3021. PubMed ID: 30028142 [TBL] [Abstract][Full Text] [Related]
19. Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation. Kumar A; Kant S; Singh SM Chem Biol Interact; 2012 Jul; 199(1):29-37. PubMed ID: 22705712 [TBL] [Abstract][Full Text] [Related]
20. Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase. Kinnaird A; Dromparis P; Saleme B; Gurtu V; Watson K; Paulin R; Zervopoulos S; Stenson T; Sutendra G; Pink DB; Carmine-Simmen K; Moore R; Lewis JD; Michelakis ED Eur Urol; 2016 Apr; 69(4):734-744. PubMed ID: 26433571 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]