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2. Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro. Fry DW; Yalowich JC; Goldman ID J Biol Chem; 1982 Feb; 257(4):1890-6. PubMed ID: 6120169 [No Abstract] [Full Text] [Related]
3. A simplified radioenzymatic assay for dihydrofolate reductase using [3H]dihydrofolate. Rothenberg SP; Iqbal MP; Da Costa M Anal Biochem; 1980 Mar; 103(1):152-6. PubMed ID: 7377540 [No Abstract] [Full Text] [Related]
4. Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate. Studies with pure enzyme and computer modeling using network thermodynamics. White JC J Biol Chem; 1979 Nov; 254(21):10889-95. PubMed ID: 387759 [No Abstract] [Full Text] [Related]
6. Nuclear magnetic resonance study of interaction of ligands with streptococcus faecium dihydrofolate reductase labeled with [gamma-13C]tryptophan. London RE; Groff JP; Cocco L; Blakley RL Biochemistry; 1982 Aug; 21(18):4450-8. PubMed ID: 7126550 [No Abstract] [Full Text] [Related]
7. Interaction of methotrexate polyglutamates and dihydrofolate during leucovorin rescue in a human breast cancer cell line (MCF-7). Allegra CJ; Boarman D Cancer Res; 1990 Jun; 50(12):3574-8. PubMed ID: 1692762 [TBL] [Abstract][Full Text] [Related]
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9. Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells. Boarman DM; Baram J; Allegra CJ Biochem Pharmacol; 1990 Dec; 40(12):2651-60. PubMed ID: 2260989 [TBL] [Abstract][Full Text] [Related]
10. Effect of 11-oxahomofolate and its reduced derivatives on human dihydrofolate reductase and on human cells having different amounts of dihydrofolate reductase. Domin BA; Cheng YC; Nair MG Biochem Pharmacol; 1982 Jan; 31(2):255-6. PubMed ID: 7059366 [No Abstract] [Full Text] [Related]
11. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells. Chen G; Wright JE; Rosowsky A Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904 [TBL] [Abstract][Full Text] [Related]
13. Synthesis and biological activity of folic acid and methotrexate analogues containing L-threo-(2S,4S)-4-fluoroglutamic acid and DL-3,3-difluoroglutamic acid. Hart BP; Haile WH; Licato NJ; Bolanowska WE; McGuire JJ; Coward JK J Med Chem; 1996 Jan; 39(1):56-65. PubMed ID: 8568827 [TBL] [Abstract][Full Text] [Related]
14. The inhibition of dihydrofolate reductase by folate analogues: structural requirements for slow- and tight-binding inhibition. Williams JW; Duggleby RG; Cutler R; Morrison JF Biochem Pharmacol; 1980 Feb; 29(4):589-95. PubMed ID: 7370052 [No Abstract] [Full Text] [Related]
15. The effects of combined antifolates on inhibition of growth of murine leukemia cells cultured in vitro. Balińska M; Szablewska I; Janiszewska D; Bartuzi K; Pawełczak K Acta Biochim Pol; 1997; 44(4):743-50. PubMed ID: 9584854 [TBL] [Abstract][Full Text] [Related]
16. Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis. Maglia G; Allemann RK J Am Chem Soc; 2003 Nov; 125(44):13372-3. PubMed ID: 14583029 [TBL] [Abstract][Full Text] [Related]
18. Calculations by complete neglect of differential overlap (CNDO/2) on dihydrofolic acid: role of N(5) in reduction by dihydrofolate reductase. Gund P; Poe M; Hoogsteen KH Mol Pharmacol; 1977 Nov; 13(6):1111-5. PubMed ID: 593265 [No Abstract] [Full Text] [Related]