BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

347 related articles for article (PubMed ID: 35176233)

  • 1. The switch from client holding to folding in the Hsp70/Hsp90 chaperone machineries is regulated by a direct interplay between co-chaperones.
    Dahiya V; Rutz DA; Moessmer P; Mühlhofer M; Lawatscheck J; Rief M; Buchner J
    Mol Cell; 2022 Apr; 82(8):1543-1556.e6. PubMed ID: 35176233
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism.
    Wang RY; Noddings CM; Kirschke E; Myasnikov AG; Johnson JL; Agard DA
    Nature; 2022 Jan; 601(7893):460-464. PubMed ID: 34937942
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop.
    Alvira S; Cuéllar J; Röhl A; Yamamoto S; Itoh H; Alfonso C; Rivas G; Buchner J; Valpuesta JM
    Nat Commun; 2014 Nov; 5():5484. PubMed ID: 25407331
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hsp70 forms antiparallel dimers stabilized by post-translational modifications to position clients for transfer to Hsp90.
    Morgner N; Schmidt C; Beilsten-Edmands V; Ebong IO; Patel NA; Clerico EM; Kirschke E; Daturpalli S; Jackson SE; Agard D; Robinson CV
    Cell Rep; 2015 May; 11(5):759-69. PubMed ID: 25921532
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex.
    Hernández MP; Sullivan WP; Toft DO
    J Biol Chem; 2002 Oct; 277(41):38294-304. PubMed ID: 12161444
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The Hsp70-Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration.
    Bhattacharya K; Picard D
    Cell Mol Life Sci; 2021 Dec; 78(23):7257-7273. PubMed ID: 34677645
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism.
    Noddings CM; Wang RY; Johnson JL; Agard DA
    Nature; 2022 Jan; 601(7893):465-469. PubMed ID: 34937936
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery.
    Kanelakis KC; Morishima Y; Dittmar KD; Galigniana MD; Takayama S; Reed JC; Pratt WB
    J Biol Chem; 1999 Nov; 274(48):34134-40. PubMed ID: 10567384
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles.
    Kirschke E; Goswami D; Southworth D; Griffin PR; Agard DA
    Cell; 2014 Jun; 157(7):1685-97. PubMed ID: 24949977
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Stimulation of the weak ATPase activity of human hsp90 by a client protein.
    McLaughlin SH; Smith HW; Jackson SE
    J Mol Biol; 2002 Jan; 315(4):787-98. PubMed ID: 11812147
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylation of the Hsp90 Co-Chaperone Hop Changes its Conformational Dynamics and Biological Function.
    Castelli M; Bhattacharya K; Abboud E; Serapian SA; Picard D; Colombo G
    J Mol Biol; 2023 Feb; 435(3):167931. PubMed ID: 36572238
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.
    Brychzy A; Rein T; Winklhofer KF; Hartl FU; Young JC; Obermann WM
    EMBO J; 2003 Jul; 22(14):3613-23. PubMed ID: 12853476
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Exploring Mechanisms of Allosteric Regulation and Communication Switching in the Multiprotein Regulatory Complexes of the Hsp90 Chaperone with Cochaperones and Client Proteins: Atomistic Insights from Integrative Biophysical Modeling and Network Analysis of Conformational Landscapes.
    Verkhivker GM
    J Mol Biol; 2022 Sep; 434(17):167506. PubMed ID: 35202628
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system.
    Morishima Y; Kanelakis KC; Silverstein AM; Dittmar KD; Estrada L; Pratt WB
    J Biol Chem; 2000 Mar; 275(10):6894-900. PubMed ID: 10702249
    [TBL] [Abstract][Full Text] [Related]  

  • 15. CHIP: A Co-chaperone for Degradation by the Proteasome and Lysosome.
    Chakraborty A; Edkins AL
    Subcell Biochem; 2023; 101():351-387. PubMed ID: 36520313
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.
    Pratt WB; Toft DO
    Exp Biol Med (Maywood); 2003 Feb; 228(2):111-33. PubMed ID: 12563018
    [TBL] [Abstract][Full Text] [Related]  

  • 17. NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems.
    Biebl MM; Delhommel F; Faust O; Zak KM; Agam G; Guo X; Mühlhofer M; Dahiya V; Hillebrand D; Popowicz GM; Kampmann M; Lamb DC; Rosenzweig R; Sattler M; Buchner J
    Mol Cell; 2022 Feb; 82(3):555-569.e7. PubMed ID: 35063133
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation.
    Dittmar KD; Pratt WB
    J Biol Chem; 1997 May; 272(20):13047-54. PubMed ID: 9148915
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Coordinated Conformational Processing of the Tumor Suppressor Protein p53 by the Hsp70 and Hsp90 Chaperone Machineries.
    Dahiya V; Agam G; Lawatscheck J; Rutz DA; Lamb DC; Buchner J
    Mol Cell; 2019 May; 74(4):816-830.e7. PubMed ID: 31027879
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70.
    Dittmar KD; Demady DR; Stancato LF; Krishna P; Pratt WB
    J Biol Chem; 1997 Aug; 272(34):21213-20. PubMed ID: 9261129
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.