BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

311 related articles for article (PubMed ID: 35179198)

  • 21. The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.
    Polinski NK; Martinez TN; Ramboz S; Sasner M; Herberth M; Switzer R; Ahmad SO; Pelligrino LJ; Clark SW; Marcus JN; Smith SM; Dave KD; Frasier MA
    Dis Model Mech; 2022 Jun; 15(6):. PubMed ID: 35419585
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
    Glajch KE; Moors TE; Chen Y; Bechade PA; Nam AY; Rajsombath MM; McCaffery TD; Dettmer U; Weihofen A; Hirst WD; Selkoe DJ; Nuber S
    Proc Natl Acad Sci U S A; 2021 Aug; 118(31):. PubMed ID: 34326260
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies.
    Sardi SP; Clarke J; Viel C; Chan M; Tamsett TJ; Treleaven CM; Bu J; Sweet L; Passini MA; Dodge JC; Yu WH; Sidman RL; Cheng SH; Shihabuddin LS
    Proc Natl Acad Sci U S A; 2013 Feb; 110(9):3537-42. PubMed ID: 23297226
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease.
    Magalhaes J; Gegg ME; Migdalska-Richards A; Doherty MK; Whitfield PD; Schapira AH
    Hum Mol Genet; 2016 Aug; 25(16):3432-3445. PubMed ID: 27378698
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The Effect of p.G2019S Mutation in the
    Usenko TS; Timofeeva A; Beletskaia M; Basharova K; Baydakova G; Bezrukova A; Grunina M; Emelyanov A; Miliukhina I; Zakharova E; Pchelina S
    J Integr Neurosci; 2024 Jan; 23(1):16. PubMed ID: 38287861
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
    Kuo SH; Tasset I; Cheng MM; Diaz A; Pan MK; Lieberman OJ; Hutten SJ; Alcalay RN; Kim S; Ximénez-Embún P; Fan L; Kim D; Ko HS; Yacoubian T; Kanter E; Liu L; Tang G; Muñoz J; Sardi SP; Li A; Gan L; Cuervo AM; Sulzer D
    Sci Adv; 2022 Feb; 8(6):eabm6393. PubMed ID: 35138901
    [TBL] [Abstract][Full Text] [Related]  

  • 27. GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers.
    Kim S; Yun SP; Lee S; Umanah GE; Bandaru VVR; Yin X; Rhee P; Karuppagounder SS; Kwon SH; Lee H; Mao X; Kim D; Pandey A; Lee G; Dawson VL; Dawson TM; Ko HS
    Proc Natl Acad Sci U S A; 2018 Jan; 115(4):798-803. PubMed ID: 29311330
    [TBL] [Abstract][Full Text] [Related]  

  • 28. D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model.
    Kim D; Hwang H; Choi S; Kwon SH; Lee S; Park JH; Kim S; Ko HS
    Acta Neuropathol Commun; 2018 Apr; 6(1):32. PubMed ID: 29703245
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration.
    Soria FN; Engeln M; Martinez-Vicente M; Glangetas C; López-González MJ; Dovero S; Dehay B; Normand E; Vila M; Favereaux A; Georges F; Lo Bianco C; Bezard E; Fernagut PO
    Hum Mol Genet; 2017 Jul; 26(14):2603-2615. PubMed ID: 28520872
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease.
    Stojkovska I; Krainc D; Mazzulli JR
    Cell Tissue Res; 2018 Jul; 373(1):51-60. PubMed ID: 29064079
    [TBL] [Abstract][Full Text] [Related]  

  • 31. A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
    Cosden M; Jinn S; Yao L; Gretzula CA; Kandebo M; Toolan D; Hatcher NG; Ma L; Lemaire W; Adam GC; Burlein C; Minnick C; Flick R; Watt ML; Mulhearn J; Fraley M; Drolet RE; Marcus JN; Smith SM
    Neurobiol Dis; 2021 Nov; 159():105507. PubMed ID: 34509608
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Inhibition of cysteine protease cathepsin L increases the level and activity of lysosomal glucocerebrosidase.
    Kim MJ; Kim S; Reinheckel T; Krainc D
    JCI Insight; 2024 Feb; 9(3):. PubMed ID: 38329128
    [TBL] [Abstract][Full Text] [Related]  

  • 33. DNA Methylation of α-Synuclein Intron 1 Is Significantly Decreased in the Frontal Cortex of Parkinson's Individuals with
    Smith AR; Richards DM; Lunnon K; Schapira AHV; Migdalska-Richards A
    Int J Mol Sci; 2023 Jan; 24(3):. PubMed ID: 36769009
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques.
    Sucunza D; Rico AJ; Roda E; Collantes M; González-Aseguinolaza G; Rodríguez-Pérez AI; Peñuelas I; Vázquez A; Labandeira-García JL; Broccoli V; Lanciego JL
    Int J Mol Sci; 2021 May; 22(9):. PubMed ID: 34062940
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Glucocerebrosidase dysfunction in neurodegenerative disease.
    Brooker SM; Krainc D
    Essays Biochem; 2021 Dec; 65(7):873-883. PubMed ID: 34528667
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile.
    Lerche S; Machetanz G; Wurster I; Roeben B; Zimmermann M; Pilotto A; Preische O; Stransky E; Deuschle C; Hauser AK; Schulte C; Lachmann I; Waniek K; Gasser T; Berg D; Maetzler W; Brockmann K
    Mov Disord; 2019 Jul; 34(7):1069-1073. PubMed ID: 31189032
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients.
    Parnetti L; Paciotti S; Eusebi P; Dardis A; Zampieri S; Chiasserini D; Tasegian A; Tambasco N; Bembi B; Calabresi P; Beccari T
    Mov Disord; 2017 Oct; 32(10):1423-1431. PubMed ID: 28843015
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease.
    García-Sanz P; M F G Aerts J; Moratalla R
    Mov Disord; 2021 May; 36(5):1070-1085. PubMed ID: 33219714
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice.
    Migdalska-Richards A; Wegrzynowicz M; Rusconi R; Deangeli G; Di Monte DA; Spillantini MG; Schapira AHV
    Brain; 2017 Oct; 140(10):2706-2721. PubMed ID: 28969384
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.
    Rockenstein E; Clarke J; Viel C; Panarello N; Treleaven CM; Kim C; Spencer B; Adame A; Park H; Dodge JC; Cheng SH; Shihabuddin LS; Masliah E; Sardi SP
    Hum Mol Genet; 2016 Jul; 25(13):2645-2660. PubMed ID: 27126635
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 16.