These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

229 related articles for article (PubMed ID: 35194165)

  • 1. APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons.
    Wu CI; Vinton EA; Pearse RV; Heo K; Aylward AJ; Hsieh YC; Bi Y; Adeleye S; Fancher S; Duong DM; Seyfried NT; Schwarz TL; Young-Pearse TL
    Mol Psychiatry; 2022 Apr; 27(4):1970-1989. PubMed ID: 35194165
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.
    García-Cerro S; Rueda N; Vidal V; Lantigua S; Martínez-Cué C
    Neurobiol Dis; 2017 Oct; 106():76-88. PubMed ID: 28647555
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease.
    Ryoo SR; Cho HJ; Lee HW; Jeong HK; Radnaabazar C; Kim YS; Kim MJ; Son MY; Seo H; Chung SH; Song WJ
    J Neurochem; 2008 Mar; 104(5):1333-44. PubMed ID: 18005339
    [TBL] [Abstract][Full Text] [Related]  

  • 4. DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity.
    Zhu B; Parsons T; Foley C; Shaw Y; Dunckley T; Hulme C; Hodge JJL
    Sci Rep; 2022 Sep; 12(1):15847. PubMed ID: 36151233
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy.
    Fertan E; Böken D; Murray A; Danial JSH; Lam JYL; Wu Y; Goh PA; Alić I; Cheetham MR; Lobanova E; Zhang YP; Nižetić D; Klenerman D
    Mol Psychiatry; 2024 Feb; 29(2):369-386. PubMed ID: 38102482
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons.
    Ovchinnikov DA; Korn O; Virshup I; Wells CA; Wolvetang EJ
    Stem Cell Reports; 2018 Jul; 11(1):32-42. PubMed ID: 29861166
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.
    Chen XQ; Salehi A; Pearn ML; Overk C; Nguyen PD; Kleschevnikov AM; Maccecchini M; Mobley WC
    Alzheimers Dement; 2021 Feb; 17(2):271-292. PubMed ID: 32975365
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts.
    Kawakubo T; Mori R; Shirotani K; Iwata N; Asai M
    Biol Pharm Bull; 2017; 40(3):327-333. PubMed ID: 28250274
    [TBL] [Abstract][Full Text] [Related]  

  • 9. [Elucidating Pathogenic Mechanisms of Early-onset Alzheimer's Disease in Down Syndrome Patients].
    Asai M; Kawakubo T; Mori R; Iwata N
    Yakugaku Zasshi; 2017; 137(7):801-805. PubMed ID: 28674290
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.
    Ochalek A; Mihalik B; Avci HX; Chandrasekaran A; Téglási A; Bock I; Giudice ML; Táncos Z; Molnár K; László L; Nielsen JE; Holst B; Freude K; Hyttel P; Kobolák J; Dinnyés A
    Alzheimers Res Ther; 2017 Dec; 9(1):90. PubMed ID: 29191219
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues.
    London J; Rouch C; Bui LC; Assayag E; Souchet B; Daubigney F; Medjaoui H; Luquet S; Magnan C; Delabar JM; Dairou J; Janel N
    Mol Neurobiol; 2018 May; 55(5):3822-3831. PubMed ID: 28540658
    [TBL] [Abstract][Full Text] [Related]  

  • 12. APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease.
    Hung C; Fertan E; Livesey FJ; Klenerman D; Patani R
    Brain; 2024 Jul; 147(7):2325-2333. PubMed ID: 38527856
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons.
    Chaves RS; Tran M; Holder AR; Balcer AM; Dickey AM; Roberts EA; Bober BG; Gutierrez E; Head BP; Groisman A; Goldstein LSB; Almenar-Queralt A; Shah SB
    J Neurosci; 2021 Dec; 41(49):10034-10053. PubMed ID: 34663629
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Alzheimer's gene SORL1 is a regulator of endosomal traffic and recycling in human neurons.
    Mishra S; Knupp A; Szabo MP; Williams CA; Kinoshita C; Hailey DW; Wang Y; Andersen OM; Young JE
    Cell Mol Life Sci; 2022 Feb; 79(3):162. PubMed ID: 35226190
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99).
    Jiang Y; Sato Y; Im E; Berg M; Bordi M; Darji S; Kumar A; Mohan PS; Bandyopadhyay U; Diaz A; Cuervo AM; Nixon RA
    J Neurosci; 2019 Jul; 39(27):5255-5268. PubMed ID: 31043483
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and presynaptic deficits.
    Mesa H; Zhang EY; Wang Y; Zhang Q
    J Cell Physiol; 2024 Jun; 239(6):e30999. PubMed ID: 36966431
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Modeling neurogenesis impairment in Down syndrome with induced pluripotent stem cells from Trisomy 21 amniotic fluid cells.
    Lu HE; Yang YC; Chen SM; Su HL; Huang PC; Tsai MS; Wang TH; Tseng CP; Hwang SM
    Exp Cell Res; 2013 Feb; 319(4):498-505. PubMed ID: 23041301
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of tau protein in neuronal damage in Alzheimer's disease and Down syndrome.
    Cárdenas AM; Ardiles AO; Barraza N; Baéz-Matus X; Caviedes P
    Arch Med Res; 2012 Nov; 43(8):645-54. PubMed ID: 23142525
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
    Israel MA; Yuan SH; Bardy C; Reyna SM; Mu Y; Herrera C; Hefferan MP; Van Gorp S; Nazor KL; Boscolo FS; Carson CT; Laurent LC; Marsala M; Gage FH; Remes AM; Koo EH; Goldstein LS
    Nature; 2012 Jan; 482(7384):216-20. PubMed ID: 22278060
    [TBL] [Abstract][Full Text] [Related]  

  • 20. DYRK1A Regulates the Bidirectional Axonal Transport of APP in Human-Derived Neurons.
    Fernandez Bessone I; Navarro J; Martinez E; Karmirian K; Holubiec M; Alloatti M; Goto-Silva L; Arnaiz Yepez C; Martins-de-Souza D; Minardi Nascimento J; Bruno L; Saez TM; Rehen SK; Falzone TL
    J Neurosci; 2022 Aug; 42(33):6344-6358. PubMed ID: 35803734
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 12.