BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

205 related articles for article (PubMed ID: 35266114)

  • 41. The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate.
    Yan R; Han P; Miao H; Greengard P; Xu H
    J Biol Chem; 2001 Sep; 276(39):36788-96. PubMed ID: 11466313
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
    Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
    Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization.
    Langness VF; van der Kant R; Das U; Wang L; Chaves RDS; Goldstein LSB
    Mol Biol Cell; 2021 Feb; 32(3):247-259. PubMed ID: 33296223
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer's disease via BACE1-mediated APP processing.
    Wang Y; Cui Y; Liu J; Song Q; Cao M; Hou Y; Zhang X; Wang P
    Alzheimers Res Ther; 2022 Jul; 14(1):103. PubMed ID: 35883144
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance.
    Mañucat-Tan NB; Saadipour K; Wang YJ; Bobrovskaya L; Zhou XF
    Mol Neurobiol; 2019 Feb; 56(2):812-830. PubMed ID: 29797184
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
    Schilling S; Pradhan A; Heesch A; Helbig A; Blennow K; Koch C; Bertgen L; Koo EH; Brinkmalm G; Zetterberg H; Kins S; Eggert S
    Acta Neuropathol Commun; 2023 Jun; 11(1):87. PubMed ID: 37259128
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
    Shi XP; Tugusheva K; Bruce JE; Lucka A; Chen-Dodson E; Hu B; Wu GX; Price E; Register RB; Lineberger J; Miller R; Tang MJ; Espeseth A; Kahana J; Wolfe A; Crouthamel MC; Sankaranarayanan S; Simon A; Chen L; Lai MT; Pietrak B; DiMuzio J; Li Y; Xu M; Huang Q; Garsky V; Sardana MK; Hazuda DJ
    J Alzheimers Dis; 2005 Apr; 7(2):139-48; discussion 173-80. PubMed ID: 15851852
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.
    Feng T; Tammineni P; Agrawal C; Jeong YY; Cai Q
    J Biol Chem; 2017 Feb; 292(5):1679-1690. PubMed ID: 28028177
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain.
    Lundgren JL; Vandermeulen L; Sandebring-Matton A; Ahmed S; Winblad B; Di Luca M; Tjernberg LO; Marcello E; Frykman S
    BMC Neurosci; 2020 Feb; 21(1):6. PubMed ID: 32019490
    [TBL] [Abstract][Full Text] [Related]  

  • 50. pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo.
    Zhao L; Zhao Y; Tang FL; Xiong L; Su C; Mei L; Zhu XJ; Xiong WC
    Cells; 2019 May; 8(5):. PubMed ID: 31108937
    [TBL] [Abstract][Full Text] [Related]  

  • 51. BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation: Beta Prime-Mediated Competitive Depletion of sAβPPα.
    Owens L; Bracewell J; Benedetto A; Dawson N; Gaffney C; Parkin E
    J Alzheimers Dis; 2022; 86(3):1201-1220. PubMed ID: 35180123
    [TBL] [Abstract][Full Text] [Related]  

  • 52. A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production.
    Buggia-Prévot V; Fernandez CG; Udayar V; Vetrivel KS; Elie A; Roseman J; Sasse VA; Lefkow M; Meckler X; Bhattacharyya S; George M; Kar S; Bindokas VP; Parent AT; Rajendran L; Band H; Vassar R; Thinakaran G
    Cell Rep; 2013 Dec; 5(6):1552-63. PubMed ID: 24373286
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.
    Shi XP; Tugusheva K; Bruce JE; Lucka A; Wu GX; Chen-Dodson E; Price E; Li Y; Xu M; Huang Q; Sardana MK; Hazuda DJ
    J Biol Chem; 2003 Jun; 278(23):21286-94. PubMed ID: 12665519
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Spatial-Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP Processing Site.
    Wang J; Gleeson PA; Fourriere L
    Traffic; 2024 Mar; 25(3):e12932. PubMed ID: 38528836
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons.
    Sun M; Huang C; Wang H; Zhang H
    Neurobiol Aging; 2019 May; 77():87-93. PubMed ID: 30784815
    [TBL] [Abstract][Full Text] [Related]  

  • 56. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.
    Sala Frigerio C; Fadeeva JV; Minogue AM; Citron M; Van Leuven F; Staufenbiel M; Paganetti P; Selkoe DJ; Walsh DM
    FEBS J; 2010 Mar; 277(6):1503-18. PubMed ID: 20163459
    [TBL] [Abstract][Full Text] [Related]  

  • 57. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
    McPhie DL; Golde T; Eckman CB; Yager D; Brant JB; Neve RL
    Brain Res Mol Brain Res; 2001 Dec; 97(1):103-13. PubMed ID: 11744168
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons.
    Mamada N; Tanokashira D; Hosaka A; Kametani F; Tamaoka A; Araki W
    Mol Brain; 2015 Nov; 8(1):73. PubMed ID: 26552445
    [TBL] [Abstract][Full Text] [Related]  

  • 59. PS1 Affects the Pathology of Alzheimer's Disease by Regulating BACE1 Distribution in the ER and BACE1 Maturation in the Golgi Apparatus.
    Li N; Qiu Y; Wang H; Zhao J; Qing H
    Int J Mol Sci; 2022 Dec; 23(24):. PubMed ID: 36555791
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
    Thinakaran G; Teplow DB; Siman R; Greenberg B; Sisodia SS
    J Biol Chem; 1996 Apr; 271(16):9390-7. PubMed ID: 8621605
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.