These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

156 related articles for article (PubMed ID: 35293427)

  • 1. Computational approaches towards the discovery and optimisation of cruzain inhibitors.
    Santos VC; Ferreira RS
    Mem Inst Oswaldo Cruz; 2022; 117():e210385. PubMed ID: 35293427
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Thiosemicarbazone derivatives: Evaluation as cruzipain inhibitors and molecular modeling study of complexes with cruzain.
    Jasinski G; Salas-Sarduy E; Vega D; Fabian L; Martini MF; Moglioni AG
    Bioorg Med Chem; 2022 May; 61():116708. PubMed ID: 35334448
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.
    Lima AP; dos Reis FC; Serveau C; Lalmanach G; Juliano L; Ménard R; Vernet T; Thomas DY; Storer AC; Scharfstein J
    Mol Biochem Parasitol; 2001 Apr; 114(1):41-52. PubMed ID: 11356512
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi.
    Engel JC; Doyle PS; Palmer J; Hsieh I; Bainton DF; McKerrow JH
    J Cell Sci; 1998 Mar; 111 ( Pt 5)():597-606. PubMed ID: 9454733
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of Novel Inhibitors of Cruzain Cysteine Protease of
    Prates JLB; Lopes JR; Chin CM; Ferreira EI; Dos Santos JL; Scarim CB
    Curr Med Chem; 2024; 31(16):2285-2308. PubMed ID: 37888814
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Investigating the Lack of Translation from Cruzain Inhibition to Trypanosoma cruzi Activity with Machine Learning and Chemical Space Analyses.
    Lameiro RF; Montanari CA
    ChemMedChem; 2023 Mar; 18(6):e202200434. PubMed ID: 36692246
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.
    Choe Y; Brinen LS; Price MS; Engel JC; Lange M; Grisostomi C; Weston SG; Pallai PV; Cheng H; Hardy LW; Hartsough DS; McMakin M; Tilton RF; Baldino CM; Craik CS
    Bioorg Med Chem; 2005 Mar; 13(6):2141-56. PubMed ID: 15727867
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
    Chen YT; Brinen LS; Kerr ID; Hansell E; Doyle PS; McKerrow JH; Roush WR
    PLoS Negl Trop Dis; 2010 Sep; 4(9):. PubMed ID: 20856868
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi.
    Engel JC; Torres C; Hsieh I; Doyle PS; McKerrow JH
    J Cell Sci; 2000 Apr; 113 ( Pt 8)():1345-54. PubMed ID: 10725218
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The crystal structure of cruzain: a therapeutic target for Chagas' disease.
    McGrath ME; Eakin AE; Engel JC; McKerrow JH; Craik CS; Fletterick RJ
    J Mol Biol; 1995 Mar; 247(2):251-9. PubMed ID: 7707373
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel cruzain inhibitors for the treatment of Chagas' disease.
    Rogers KE; Keränen H; Durrant JD; Ratnam J; Doak A; Arkin MR; McCammon JA
    Chem Biol Drug Des; 2012 Sep; 80(3):398-405. PubMed ID: 22613098
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases.
    Yong V; Schmitz V; Vannier-Santos MA; de Lima AP; Lalmanach G; Juliano L; Gauthier F; Scharfstein J
    Mol Biochem Parasitol; 2000 Jun; 109(1):47-59. PubMed ID: 10924756
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Quantitative structure-activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: molecular modeling, CoMFA and CoMSIA studies.
    Trossini GH; Guido RV; Oliva G; Ferreira EI; Andricopulo AD
    J Mol Graph Model; 2009 Aug; 28(1):3-11. PubMed ID: 19376735
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
    Mott BT; Ferreira RS; Simeonov A; Jadhav A; Ang KK; Leister W; Shen M; Silveira JT; Doyle PS; Arkin MR; McKerrow JH; Inglese J; Austin CP; Thomas CJ; Shoichet BK; Maloney DJ
    J Med Chem; 2010 Jan; 53(1):52-60. PubMed ID: 19908842
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach.
    Hernández Alvarez L; Barreto Gomes DE; Hernández González JE; Pascutti PG
    PLoS One; 2019; 14(1):e0211227. PubMed ID: 30682119
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of a new class of nonpeptidic inhibitors of cruzain.
    Brak K; Doyle PS; McKerrow JH; Ellman JA
    J Am Chem Soc; 2008 May; 130(20):6404-10. PubMed ID: 18435536
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.
    Chenna BC; Li L; Mellott DM; Zhai X; Siqueira-Neto JL; Calvet Alvarez C; Bernatchez JA; Desormeaux E; Alvarez Hernandez E; Gomez J; McKerrow JH; Cruz-Reyes J; Meek TD
    J Med Chem; 2020 Mar; 63(6):3298-3316. PubMed ID: 32125159
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors.
    Burtoloso AC; de Albuquerque S; Furber M; Gomes JC; Gonçalez C; Kenny PW; Leitão A; Montanari CA; Quilles JC; Ribeiro JF; Rocha JR
    PLoS Negl Trop Dis; 2017 Feb; 11(2):e0005343. PubMed ID: 28222138
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles.
    Dos Santos AM; Cianni L; De Vita D; Rosini F; Leitão A; Laughton CA; Lameira J; Montanari CA
    Phys Chem Chem Phys; 2018 Sep; 20(37):24317-24328. PubMed ID: 30211406
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism.
    Silva JRA; Cianni L; Araujo D; Batista PHJ; de Vita D; Rosini F; Leitão A; Lameira J; Montanari CA
    J Chem Inf Model; 2020 Mar; 60(3):1666-1677. PubMed ID: 32126170
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.