204 related articles for article (PubMed ID: 35293758)
1. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells.
Smalley JP; Baker IM; Pytel WA; Lin LY; Bowman KJ; Schwabe JWR; Cowley SM; Hodgkinson JT
J Med Chem; 2022 Apr; 65(7):5642-5659. PubMed ID: 35293758
[TBL] [Abstract][Full Text] [Related]
2. Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs).
Baker IM; Smalley JP; Sabat KA; Hodgkinson JT; Cowley SM
Biochemistry; 2023 Feb; 62(3):645-656. PubMed ID: 35948047
[TBL] [Abstract][Full Text] [Related]
3. Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders.
Setia N; Almuqdadi HTA; Abid M
Eur J Med Chem; 2024 Feb; 265():116041. PubMed ID: 38199162
[TBL] [Abstract][Full Text] [Related]
4. PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes.
Smalley JP; Adams GE; Millard CJ; Song Y; Norris JKS; Schwabe JWR; Cowley SM; Hodgkinson JT
Chem Commun (Camb); 2020 Apr; 56(32):4476-4479. PubMed ID: 32201871
[TBL] [Abstract][Full Text] [Related]
5. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs.
Girardini M; Maniaci C; Hughes SJ; Testa A; Ciulli A
Bioorg Med Chem; 2019 Jun; 27(12):2466-2479. PubMed ID: 30826187
[TBL] [Abstract][Full Text] [Related]
6. Vascular endothelial growth factor production is induced by histone deacetylase 1 and suppressed by von Hippel-Lindau protein in HaCaT cells.
Reynoso-Roldán A; Roldán ML; Cancino-Diaz JC; Rodríguez-Martínez S; Cancino-Diaz ME
Clin Invest Med; 2012 Dec; 35(6):E340-50. PubMed ID: 23217559
[TBL] [Abstract][Full Text] [Related]
7. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.
Maniaci C; Hughes SJ; Testa A; Chen W; Lamont DJ; Rocha S; Alessi DR; Romeo R; Ciulli A
Nat Commun; 2017 Oct; 8(1):830. PubMed ID: 29018234
[TBL] [Abstract][Full Text] [Related]
8. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.
Zoppi V; Hughes SJ; Maniaci C; Testa A; Gmaschitz T; Wieshofer C; Koegl M; Riching KM; Daniels DL; Spallarossa A; Ciulli A
J Med Chem; 2019 Jan; 62(2):699-726. PubMed ID: 30540463
[TBL] [Abstract][Full Text] [Related]
9. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.
Jia H; Pallos J; Jacques V; Lau A; Tang B; Cooper A; Syed A; Purcell J; Chen Y; Sharma S; Sangrey GR; Darnell SB; Plasterer H; Sadri-Vakili G; Gottesfeld JM; Thompson LM; Rusche JR; Marsh JL; Thomas EA
Neurobiol Dis; 2012 May; 46(2):351-61. PubMed ID: 22590724
[TBL] [Abstract][Full Text] [Related]
10. Design and optimization of oestrogen receptor PROTACs based on 4-hydroxytamoxifen.
Loren G; Espuny I; Llorente A; Donoghue C; Verdaguer X; Gomis RR; Riera A
Eur J Med Chem; 2022 Dec; 243():114770. PubMed ID: 36148710
[TBL] [Abstract][Full Text] [Related]
11. Chemo-proteomics exploration of HDAC degradability by small molecule degraders.
Xiong Y; Donovan KA; Eleuteri NA; Kirmani N; Yue H; Razov A; Krupnick NM; Nowak RP; Fischer ES
Cell Chem Biol; 2021 Oct; 28(10):1514-1527.e4. PubMed ID: 34314730
[TBL] [Abstract][Full Text] [Related]
12. A beginner's guide to current synthetic linker strategies towards VHL-recruiting PROTACs.
Zografou-Barredo NA; Hallatt AJ; Goujon-Ricci J; Cano C
Bioorg Med Chem; 2023 Jun; 88-89():117334. PubMed ID: 37224698
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties.
Jaime-Figueroa S; Buhimschi AD; Toure M; Hines J; Crews CM
Bioorg Med Chem Lett; 2020 Feb; 30(3):126877. PubMed ID: 31879210
[TBL] [Abstract][Full Text] [Related]
14. Discovery of pomalidomide-based PROTACs for selective degradation of histone deacetylase 8.
Sun Z; Deng B; Yang Z; Mai R; Huang J; Ma Z; Chen T; Chen J
Eur J Med Chem; 2022 Sep; 239():114544. PubMed ID: 35759908
[TBL] [Abstract][Full Text] [Related]
15. Development of VHL-recruiting STING PROTACs that suppress innate immunity.
Zhu Z; Johnson RL; Zhang Z; Herring LE; Jiang G; Damania B; James LI; Liu P
Cell Mol Life Sci; 2023 May; 80(6):149. PubMed ID: 37183204
[TBL] [Abstract][Full Text] [Related]
16. MDM2 Antagonist Idasanutlin Reduces HDAC1/2 Abundance and Corepressor Partners but Not HDAC3.
Smalley JP; Cowley SM; Hodgkinson JT
ACS Med Chem Lett; 2024 Jan; 15(1):93-98. PubMed ID: 38229760
[TBL] [Abstract][Full Text] [Related]
17. Designing HDAC-PROTACs: lessons learned so far.
Fischer F; Alves Avelar LA; Murray L; Kurz T
Future Med Chem; 2022 Jan; 14(3):143-166. PubMed ID: 34951318
[TBL] [Abstract][Full Text] [Related]
18. Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin.
Hayashi A; Horiuchi A; Kikuchi N; Hayashi T; Fuseya C; Suzuki A; Konishi I; Shiozawa T
Int J Cancer; 2010 Sep; 127(6):1332-46. PubMed ID: 20049841
[TBL] [Abstract][Full Text] [Related]
19. Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC).
Cao F; de Weerd S; Chen D; Zwinderman MRH; van der Wouden PE; Dekker FJ
Eur J Med Chem; 2020 Dec; 208():112800. PubMed ID: 32971411
[TBL] [Abstract][Full Text] [Related]
20. PROTAC-mediated crosstalk between E3 ligases.
Steinebach C; Kehm H; Lindner S; Vu LP; Köpff S; López Mármol Á; Weiler C; Wagner KG; Reichenzeller M; Krönke J; Gütschow M
Chem Commun (Camb); 2019 Feb; 55(12):1821-1824. PubMed ID: 30672516
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
