These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. Feng Z; Yao Y; Zhou C; Chen F; Wu F; Wei L; Liu W; Dong S; Redell M; Mo Q; Song Y J Hematol Oncol; 2016 Mar; 9():24. PubMed ID: 26970896 [TBL] [Abstract][Full Text] [Related]
5. Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond. Chen CW; Armstrong SA Exp Hematol; 2015 Aug; 43(8):673-84. PubMed ID: 26118503 [TBL] [Abstract][Full Text] [Related]
6. DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding. Spangler CJ; Yadav SP; Li D; Geil CN; Smith CB; Wang GG; Lee TH; McGinty RK Cell Rep; 2022 Feb; 38(7):110369. PubMed ID: 35172132 [TBL] [Abstract][Full Text] [Related]
7. Therapeutic strategies against hDOT1L as a potential drug target in MLL-rearranged leukemias. Banday S; Farooq Z; Ganai SA; Altaf M Clin Epigenetics; 2020 May; 12(1):73. PubMed ID: 32450905 [TBL] [Abstract][Full Text] [Related]
8. Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. Yuan Y; Du L; Tan R; Yu Y; Jiang J; Yao A; Luo J; Tang R; Xiao Y; Sun H J Med Chem; 2022 Jun; 65(11):7770-7785. PubMed ID: 35612819 [TBL] [Abstract][Full Text] [Related]
9. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Bernt KM; Zhu N; Sinha AU; Vempati S; Faber J; Krivtsov AV; Feng Z; Punt N; Daigle A; Bullinger L; Pollock RM; Richon VM; Kung AL; Armstrong SA Cancer Cell; 2011 Jul; 20(1):66-78. PubMed ID: 21741597 [TBL] [Abstract][Full Text] [Related]
10. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Daigle SR; Olhava EJ; Therkelsen CA; Basavapathruni A; Jin L; Boriack-Sjodin PA; Allain CJ; Klaus CR; Raimondi A; Scott MP; Waters NJ; Chesworth R; Moyer MP; Copeland RA; Richon VM; Pollock RM Blood; 2013 Aug; 122(6):1017-25. PubMed ID: 23801631 [TBL] [Abstract][Full Text] [Related]
11. DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy. Liu W; Deng L; Song Y; Redell M PLoS One; 2014; 9(5):e98270. PubMed ID: 24858818 [TBL] [Abstract][Full Text] [Related]
12. Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. Deshpande AJ; Chen L; Fazio M; Sinha AU; Bernt KM; Banka D; Dias S; Chang J; Olhava EJ; Daigle SR; Richon VM; Pollock RM; Armstrong SA Blood; 2013 Mar; 121(13):2533-41. PubMed ID: 23361907 [TBL] [Abstract][Full Text] [Related]
13. The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. Wang WT; Chen TQ; Zeng ZC; Pan Q; Huang W; Han C; Fang K; Sun LY; Yang QQ; Wang D; Luo XQ; Sun YM; Chen YQ J Hematol Oncol; 2020 Jun; 13(1):78. PubMed ID: 32552847 [TBL] [Abstract][Full Text] [Related]
14. Selective DOT1L, LSD1, and HDAC Class I Inhibitors Reduce HOXA9 Expression in MLL-AF9 Rearranged Leukemia Cells, But Dysregulate the Expression of Many Histone-Modifying Enzymes. Lillico R; Lawrence CK; Lakowski TM J Proteome Res; 2018 Aug; 17(8):2657-2667. PubMed ID: 29972300 [TBL] [Abstract][Full Text] [Related]
15. DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Nguyen AT; Taranova O; He J; Zhang Y Blood; 2011 Jun; 117(25):6912-22. PubMed ID: 21521783 [TBL] [Abstract][Full Text] [Related]