62 related articles for article (PubMed ID: 3533643)
1. Design and synthesis of multisubstrate analog inhibitors of one-carbon transfer reactions.
Broom AD
Fed Proc; 1986 Nov; 45(12):2779-83. PubMed ID: 3533643
[TBL] [Abstract][Full Text] [Related]
2. Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Bavetsias V; Jackman AL; Kimbell R; Gibson W; Boyle FT; Bisset GM
J Med Chem; 1996 Jan; 39(1):73-85. PubMed ID: 8568829
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
Gangjee A; Lin X; Kisliuk RL; McGuire JJ
J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis and evaluation of potent thymidylate synthase X inhibitors.
Esra Onen F; Boum Y; Jacquement C; Spanedda MV; Jaber N; Scherman D; Myllykallio H; Herscovici J
Bioorg Med Chem Lett; 2008 Jun; 18(12):3628-31. PubMed ID: 18513963
[TBL] [Abstract][Full Text] [Related]
5. Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT).
Springer CJ; Bavetsias V; Jackman AL; Boyle FT; Marshall D; Pedley RB; Bisset GM
Anticancer Drug Des; 1996 Dec; 11(8):625-36. PubMed ID: 9022750
[TBL] [Abstract][Full Text] [Related]
6. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Jones TR; Varney MD; Webber SE; Lewis KK; Marzoni GP; Palmer CL; Kathardekar V; Welsh KM; Webber S; Matthews DA; Appelt K; Smith WW; Janson CA; Villafranca JE; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Moomaw EW; Bartlett CA; Morse CA
J Med Chem; 1996 Feb; 39(4):904-17. PubMed ID: 8632414
[TBL] [Abstract][Full Text] [Related]
7. Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.
Jones TR; Webber SE; Varney MD; Reddy MR; Lewis KK; Kathardekar V; Mazdiyasni H; Deal J; Nguyen D; Welsh KM; Webber S; Johnston A; Matthews DA; Smith WW; Janson CA; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Bartlett CA; Morse CA
J Med Chem; 1997 Feb; 40(5):677-83. PubMed ID: 9057854
[TBL] [Abstract][Full Text] [Related]
8. Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.
Gangjee A; Jain HD; McGuire JJ; Kisliuk RL
J Med Chem; 2004 Dec; 47(27):6730-9. PubMed ID: 15615522
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and antitumour activity of fluorinated 1-aza and 1,8-diazaanthraquinones.
Ramos MT; Díaz-Guerra LM; García-Copín S; Avendaño C; García-Grávalos D; García de Quesada T
Farmaco; 1996 May; 51(5):375-9. PubMed ID: 8767848
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and antimetabolic properties of 4,5-substituted pyrimidine 2'-deoxynucleosides and their 5'-monophosphates.
Kulikowski T; Bretner M; Dzik JM; Zieliński Z; Cieśla J; Rode W; Vilpo JA; Shugar D
Nucleic Acids Symp Ser; 1987; (18):61-4. PubMed ID: 3697152
[TBL] [Abstract][Full Text] [Related]
11. Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Bavetsias V; Jackman AL; Marriott JH; Kimbell R; Gibson W; Boyle FT; Bisset GM
J Med Chem; 1997 May; 40(10):1495-510. PubMed ID: 9154971
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis and anticancer activities of hybrids of indole and barbituric acids--identification of highly promising leads.
Singh P; Kaur M; Verma P
Bioorg Med Chem Lett; 2009 Jun; 19(11):3054-8. PubMed ID: 19398334
[TBL] [Abstract][Full Text] [Related]
13. Sequence-based identification of specific drug target regions in the thymidylate synthase enzyme family.
Ferrari S; Losasso V; Costi MP
ChemMedChem; 2008 Mar; 3(3):392-401. PubMed ID: 18270995
[No Abstract] [Full Text] [Related]
14. Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.
Pawełczak K; Makowski M; Kempny M; Dzik JM; Gołos B; Rode W; Rzeszotarska B
Acta Biochim Pol; 2002; 49(2):407-20. PubMed ID: 12362982
[TBL] [Abstract][Full Text] [Related]
15. Thymidylate synthase inhibitors.
Touroutoglou N; Pazdur R
Clin Cancer Res; 1996 Feb; 2(2):227-43. PubMed ID: 9816165
[TBL] [Abstract][Full Text] [Related]
16. Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.
Curtin NJ; Bowman KJ; Turner RN; Huang B; Loughlin PJ; Calvert AH; Golding BT; Griffin RJ; Newell DR
Br J Cancer; 1999 Aug; 80(11):1738-46. PubMed ID: 10468290
[TBL] [Abstract][Full Text] [Related]
17. Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation.
Jackman AL; Kimbell R; Brown M; Brunton L; Bisset GM; Bavetsias V; Marsham P; Hughes LR; Boyle FT
Anticancer Drug Des; 1995 Oct; 10(7):573-89. PubMed ID: 7495480
[TBL] [Abstract][Full Text] [Related]
18. Contributions of protein structure-based drug design to cancer chemotherapy.
Jackson RC
Semin Oncol; 1997 Apr; 24(2):164-72. PubMed ID: 9129687
[TBL] [Abstract][Full Text] [Related]
19. Pharmacological and toxicological evaluation of a new series of thymidylate synthase inhibitors as anticancer agents.
Benassi L; Magnoni C; Giudice S; Bertazzoni G; Costi MP; Rinaldi M; Venturelli A; Coppi A; Rossi T
Anticancer Res; 2006; 26(5A):3499-504. PubMed ID: 17094473
[TBL] [Abstract][Full Text] [Related]
20. Thymidylate synthase inhibitors as anticancer agents: from bench to bedside.
Chu E; Callender MA; Farrell MP; Schmitz JC
Cancer Chemother Pharmacol; 2003 Jul; 52 Suppl 1():S80-9. PubMed ID: 12819937
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
