299 related articles for article (PubMed ID: 35358569)
1. Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition.
Flanagan DJ; Woodcock SA; Phillips C; Eagle C; Sansom OJ
Pharmacol Ther; 2022 Oct; 238():108179. PubMed ID: 35358569
[TBL] [Abstract][Full Text] [Related]
2. Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway.
Shah K; Panchal S; Patel B
Pharmacol Res; 2021 May; 167():105532. PubMed ID: 33677106
[TBL] [Abstract][Full Text] [Related]
3. The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand-dependent Cancer Models.
Phillips C; Bhamra I; Eagle C; Flanagan E; Armer R; Jones CD; Bingham M; Calcraft P; Edmenson Cook A; Thompson B; Woodcock SA
Cancer Res Commun; 2022 Sep; 2(9):914-928. PubMed ID: 36922934
[TBL] [Abstract][Full Text] [Related]
4. Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Jiang X; Hao HX; Growney JD; Woolfenden S; Bottiglio C; Ng N; Lu B; Hsieh MH; Bagdasarian L; Meyer R; Smith TR; Avello M; Charlat O; Xie Y; Porter JA; Pan S; Liu J; McLaughlin ME; Cong F
Proc Natl Acad Sci U S A; 2013 Jul; 110(31):12649-54. PubMed ID: 23847203
[TBL] [Abstract][Full Text] [Related]
5. Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand-Addicted Pancreatic Cancer.
Aguilera KY; Le T; Riahi R; Lay AR; Hinz S; Saadat EA; Vashisht AA; Wohlschlegel J; Donahue TR; Radu CG; Dawson DW
Mol Cancer Ther; 2022 Jun; 21(6):936-947. PubMed ID: 35313331
[TBL] [Abstract][Full Text] [Related]
6. Modulating Wnt signaling at the root: Porcupine and Wnt acylation.
Torres VI; Godoy JA; Inestrosa NC
Pharmacol Ther; 2019 Jun; 198():34-45. PubMed ID: 30790642
[TBL] [Abstract][Full Text] [Related]
7. Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers.
Yang Q; Qin T; An T; Wu H; Xu G; Xiang J; Lei K; Zhang S; Xia J; Su G; Wang D; Xue M; Kong L; Zhang W; Wu S; Li Y
Eur J Pharmacol; 2023 Apr; 945():175628. PubMed ID: 36858339
[TBL] [Abstract][Full Text] [Related]
8. The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition.
Yu J; Yusoff PAM; Woutersen DTJ; Goh P; Harmston N; Smits R; Epstein DM; Virshup DM; Madan B
Cancer Res; 2020 Dec; 80(24):5619-5632. PubMed ID: 33067269
[TBL] [Abstract][Full Text] [Related]
9. Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors.
Dong Y; Li K; Xu Z; Ma H; Zheng J; Hu Z; He S; Wu Y; Sun Z; Luo L; Li J; Zhang H; Zhang X
Bioorg Med Chem; 2015 Nov; 23(21):6855-68. PubMed ID: 26455655
[TBL] [Abstract][Full Text] [Related]
10. Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.
Koo BK; van Es JH; van den Born M; Clevers H
Proc Natl Acad Sci U S A; 2015 Jun; 112(24):7548-50. PubMed ID: 26023187
[TBL] [Abstract][Full Text] [Related]
11. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
Liu J; Pan S; Hsieh MH; Ng N; Sun F; Wang T; Kasibhatla S; Schuller AG; Li AG; Cheng D; Li J; Tompkins C; Pferdekamper A; Steffy A; Cheng J; Kowal C; Phung V; Guo G; Wang Y; Graham MP; Flynn S; Brenner JC; Li C; Villarroel MC; Schultz PG; Wu X; McNamara P; Sellers WR; Petruzzelli L; Boral AL; Seidel HM; McLaughlin ME; Che J; Carey TE; Vanasse G; Harris JL
Proc Natl Acad Sci U S A; 2013 Dec; 110(50):20224-9. PubMed ID: 24277854
[TBL] [Abstract][Full Text] [Related]
12. Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells.
Kleszcz R; Szymańska A; Krajka-Kuźniak V; Baer-Dubowska W; Paluszczak J
Cell Oncol (Dordr); 2019 Aug; 42(4):505-520. PubMed ID: 31089983
[TBL] [Abstract][Full Text] [Related]
13. Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility.
Farah O; Biechele S; Rossant J; Dufort D
Biol Reprod; 2017 Nov; 97(5):688-697. PubMed ID: 29036275
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold.
Xu Z; Xu X; O'Laoi R; Ma H; Zheng J; Chen S; Luo L; Hu Z; He S; Li J; Zhang H; Zhang X
Bioorg Med Chem; 2016 Nov; 24(22):5861-5872. PubMed ID: 27692509
[TBL] [Abstract][Full Text] [Related]
15. Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma.
Li J; Wu G; Xu Y; Li J; Ruan N; Chen Y; Zhang Q; Xia Q
Biomed Res Int; 2020; 2020():2527643. PubMed ID: 32104684
[TBL] [Abstract][Full Text] [Related]
16. Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis.
Lu X; Rudemiller NP; Ren J; Wen Y; Yang B; Griffiths R; Privratsky JR; Madan B; Virshup DM; Crowley SD
Kidney Int; 2019 Dec; 96(6):1308-1319. PubMed ID: 31585741
[TBL] [Abstract][Full Text] [Related]
17. WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma.
Zimmerli D; Cecconi V; Valenta T; Hausmann G; Cantù C; Restivo G; Hafner J; Basler K; van den Broek M
Oncogene; 2018 Jul; 37(27):3753-3762. PubMed ID: 29662191
[TBL] [Abstract][Full Text] [Related]
18. Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI.
Agarwal P; Zhang B; Ho Y; Cook A; Li L; Mikhail FM; Wang Y; McLaughlin ME; Bhatia R
Blood; 2017 Feb; 129(8):1008-1020. PubMed ID: 28011678
[TBL] [Abstract][Full Text] [Related]
19. An
Asciolla JJ; Miele MM; Hendrickson RC; Resh MD
J Biol Chem; 2017 Aug; 292(33):13507-13513. PubMed ID: 28655768
[TBL] [Abstract][Full Text] [Related]
20. Insulin activates hepatic Wnt/β-catenin signaling through stearoyl-CoA desaturase 1 and Porcupine.
Cabrae R; Dubuquoy C; Caüzac M; Morzyglod L; Guilmeau S; Noblet B; Fève B; Postic C; Burnol AF; Moldes M
Sci Rep; 2020 Mar; 10(1):5186. PubMed ID: 32198362
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
