BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

121 related articles for article (PubMed ID: 35394495)

  • 1. Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFNγ Signaling to Gain Clonal Advantage.
    De Dominici M; DeGregori J
    Blood Cancer Discov; 2022 May; 3(3):178-180. PubMed ID: 35394495
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21.
    Zhang CR; Ostrander EL; Kukhar O; Mallaney C; Sun J; Haussler E; Celik H; Koh WK; King KY; Gontarz P; Challen GA
    Blood Cancer Discov; 2022 May; 3(3):220-239. PubMed ID: 35394496
    [TBL] [Abstract][Full Text] [Related]  

  • 3. To Degrade or Not to Degrade DNMT3A.
    Ma Y; Will B
    Cancer Discov; 2022 Jan; 12(1):23-25. PubMed ID: 35022208
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.
    Tovy A; Reyes JM; Gundry MC; Brunetti L; Lee-Six H; Petljak M; Park HJ; Guzman AG; Rosas C; Jeffries AR; Baple E; Mill J; Crosby AH; Sency V; Xin B; Machado HE; Castillo D; Weitzel JN; Li W; Stratton MR; Campbell PJ; Wang H; Sanders MA; Goodell MA
    Cell Stem Cell; 2020 Aug; 27(2):326-335.e4. PubMed ID: 32673568
    [TBL] [Abstract][Full Text] [Related]  

  • 5. DNMT3A-Mutant Leukemia Cells Primed to "Fork It Over" under DNA Damage.
    Viny AD
    Clin Cancer Res; 2022 Feb; 28(4):573-575. PubMed ID: 34880109
    [TBL] [Abstract][Full Text] [Related]  

  • 6. DNMT3A gates IFN-induced MPN HSC exhaustion.
    Constantinescu SN; Vainchenker W
    Blood; 2024 Jun; 143(24):2445-2446. PubMed ID: 38869916
    [No Abstract]   [Full Text] [Related]  

  • 7. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
    Rau RE; Rodriguez BA; Luo M; Jeong M; Rosen A; Rogers JH; Campbell CT; Daigle SR; Deng L; Song Y; Sweet S; Chevassut T; Andreeff M; Kornblau SM; Li W; Goodell MA
    Blood; 2016 Aug; 128(7):971-81. PubMed ID: 27335278
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling.
    Hormaechea-Agulla D; Matatall KA; Le DT; Kain B; Long X; Kus P; Jaksik R; Challen GA; Kimmel M; King KY
    Cell Stem Cell; 2021 Aug; 28(8):1428-1442.e6. PubMed ID: 33743191
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.
    Nam AS; Dusaj N; Izzo F; Murali R; Myers RM; Mouhieddine TH; Sotelo J; Benbarche S; Waarts M; Gaiti F; Tahri S; Levine R; Abdel-Wahab O; Godley LA; Chaligne R; Ghobrial I; Landau DA
    Nat Genet; 2022 Oct; 54(10):1514-1526. PubMed ID: 36138229
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hematopoietic differentiation persists in human iPSCs defective in de novo DNA methylation.
    Cypris O; Franzen J; Frobel J; Glück P; Kuo CC; Schmitz S; Nüchtern S; Zenke M; Wagner W
    BMC Biol; 2022 Jun; 20(1):141. PubMed ID: 35705990
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response.
    Scheller M; Ludwig AK; Göllner S; Rohde C; Krämer S; Stäble S; Janssen M; Müller JA; He L; Bäumer N; Arnold C; Gerß J; Schönung M; Thiede C; Niederwieser C; Niederwieser D; Serve H; Berdel WE; Thiem U; Hemmerling I; Leuschner F; Plass C; Schlesner M; Zaugg J; Milsom MD; Trumpp A; Pabst C; Lipka DB; Müller-Tidow C
    Nat Cancer; 2021 May; 2(5):527-544. PubMed ID: 35122024
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease.
    Sano S; Oshima K; Wang Y; Katanasaka Y; Sano M; Walsh K
    Circ Res; 2018 Jul; 123(3):335-341. PubMed ID: 29728415
    [TBL] [Abstract][Full Text] [Related]  

  • 13. miR-196b-TLR7/8 Signaling Axis Regulates Innate Immune Signaling and Myeloid Maturation in DNMT3A-Mutant AML.
    Gamlen HA; Romer-Seibert JS; Lawler ME; Versace AM; Goetz ML; Feng Y; Guryanova OA; Palmisiano N; Meyer SE
    Clin Cancer Res; 2022 Oct; 28(20):4574-4586. PubMed ID: 35943291
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
    Cole CB; Russler-Germain DA; Ketkar S; Verdoni AM; Smith AM; Bangert CV; Helton NM; Guo M; Klco JM; O'Laughlin S; Fronick C; Fulton R; Chang GS; Petti AA; Miller CA; Ley TJ
    J Clin Invest; 2017 Oct; 127(10):3657-3674. PubMed ID: 28872462
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells.
    Wang Q; Liu Y; Wang H; Jiang P; Qian W; You M; Han Y; Zeng X; Li J; Lu H; Jiang L; Zhu M; Li S; Huang K; Tang M; Wang X; Yan L; Xiong Z; Shi X; Bai G; Liu H; Li Y; Zhao Y; Chen C; Qian P
    Nat Commun; 2022 Sep; 13(1):5657. PubMed ID: 36163326
    [TBL] [Abstract][Full Text] [Related]  

  • 16. DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells.
    Ramabadran R; Wang JH; Reyes JM; Guzman AG; Gupta S; Rosas C; Brunetti L; Gundry MC; Tovy A; Long H; Gu T; Cullen SM; Tyagi S; Rux D; Kim JJ; Kornblau SM; Kyba M; Stossi F; Rau RE; Takahashi K; Westbrook TF; Goodell MA
    Nat Cell Biol; 2023 Apr; 25(4):528-539. PubMed ID: 37024683
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Heterozygous Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool.
    Higo T; Suzuki Y; Sato M; Koya J; Mizuno H; Miyauchi M; Masamoto Y; Kataoka K; Sumitomo Y; Tsuruta-Kishino T; Sato T; Kurokawa M
    Exp Hematol; 2022 May; 109():45-54. PubMed ID: 35245608
    [TBL] [Abstract][Full Text] [Related]  

  • 18. DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.
    Guryanova OA; Shank K; Spitzer B; Luciani L; Koche RP; Garrett-Bakelman FE; Ganzel C; Durham BH; Mohanty A; Hoermann G; Rivera SA; Chramiec AG; Pronier E; Bastian L; Keller MD; Tovbin D; Loizou E; Weinstein AR; Gonzalez AR; Lieu YK; Rowe JM; Pastore F; McKenney AS; Krivtsov AV; Sperr WR; Cross JR; Mason CE; Tallman MS; Arcila ME; Abdel-Wahab O; Armstrong SA; Kubicek S; Staber PB; Gönen M; Paietta EM; Melnick AM; Nimer SD; Mukherjee S; Levine RL
    Nat Med; 2016 Dec; 22(12):1488-1495. PubMed ID: 27841873
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo.
    Jeong M; Park HJ; Celik H; Ostrander EL; Reyes JM; Guzman A; Rodriguez B; Lei Y; Lee Y; Ding L; Guryanova OA; Li W; Goodell MA; Challen GA
    Cell Rep; 2018 Apr; 23(1):1-10. PubMed ID: 29617651
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
    Chen DY; Ferguson IM; Braun KA; Sutton LA; Helton NM; Ramakrishnan SM; Smith AM; Miller CA; Ley TJ
    Proc Natl Acad Sci U S A; 2021 Apr; 118(16):. PubMed ID: 33846253
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.