194 related articles for article (PubMed ID: 35419951)
21. Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway.
Luo J; Wang J; Yang J; Huang W; Liu J; Tan W; Xin H
J Nat Med; 2022 Jun; 76(3):584-593. PubMed ID: 35171398
[TBL] [Abstract][Full Text] [Related]
22. mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.
Wu CC; Hou S; Orr BA; Kuo BR; Youn YH; Ong T; Roth F; Eberhart CG; Robinson GW; Solecki DJ; Taketo MM; Gilbertson RJ; Roussel MF; Han YG
Dev Cell; 2017 Dec; 43(6):673-688.e5. PubMed ID: 29103956
[TBL] [Abstract][Full Text] [Related]
23. Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.
Jia H; Liu Y; Xia R; Tong C; Yue T; Jiang J; Jia J
J Biol Chem; 2010 Nov; 285(48):37218-26. PubMed ID: 20876583
[TBL] [Abstract][Full Text] [Related]
24. Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth.
Di Magno L; Manzi D; D'Amico D; Coni S; Macone A; Infante P; Di Marcotullio L; De Smaele E; Ferretti E; Screpanti I; Agostinelli E; Gulino A; Canettieri G
Cell Cycle; 2014; 13(21):3404-13. PubMed ID: 25485584
[TBL] [Abstract][Full Text] [Related]
25. Pik3ca mutations significantly enhance the growth of SHH medulloblastoma and lead to metastatic tumour growth in a novel mouse model.
Niesen J; Ohli J; Sedlacik J; Dührsen L; Hellwig M; Spohn M; Holsten T; Schüller U
Cancer Lett; 2020 May; 477():10-18. PubMed ID: 32112900
[TBL] [Abstract][Full Text] [Related]
26. Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Robinson GW; Orr BA; Wu G; Gururangan S; Lin T; Qaddoumi I; Packer RJ; Goldman S; Prados MD; Desjardins A; Chintagumpala M; Takebe N; Kaste SC; Rusch M; Allen SJ; Onar-Thomas A; Stewart CF; Fouladi M; Boyett JM; Gilbertson RJ; Curran T; Ellison DW; Gajjar A
J Clin Oncol; 2015 Aug; 33(24):2646-54. PubMed ID: 26169613
[TBL] [Abstract][Full Text] [Related]
27. The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma.
Lospinoso Severini L; Ghirga F; Bufalieri F; Quaglio D; Infante P; Di Marcotullio L
Expert Opin Ther Targets; 2020 Nov; 24(11):1159-1181. PubMed ID: 32990091
[TBL] [Abstract][Full Text] [Related]
28. Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma.
Al-Halabi H; Nantel A; Klekner A; Guiot MC; Albrecht S; Hauser P; Garami M; Bognar L; Kavan P; Gerges N; Shirinian M; Roberge D; Muanza T; Jabado N
Acta Neuropathol; 2011 Feb; 121(2):229-39. PubMed ID: 21107850
[TBL] [Abstract][Full Text] [Related]
29. Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.
Brun SN; Markant SL; Esparza LA; Garcia G; Terry D; Huang JM; Pavlyukov MS; Li XN; Grant GA; Crawford JR; Levy ML; Conway EM; Smith LH; Nakano I; Berezov A; Greene MI; Wang Q; Wechsler-Reya RJ
Oncogene; 2015 Jul; 34(29):3770-9. PubMed ID: 25241898
[TBL] [Abstract][Full Text] [Related]
30. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
Hoch L; Faure H; Roudaut H; Schoenfelder A; Mann A; Girard N; Bihannic L; Ayrault O; Petricci E; Taddei M; Rognan D; Ruat M
FASEB J; 2015 May; 29(5):1817-29. PubMed ID: 25636740
[TBL] [Abstract][Full Text] [Related]
31. Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold.
Berardozzi S; Bernardi F; Infante P; Ingallina C; Toscano S; De Paolis E; Alfonsi R; Caimano M; Botta B; Mori M; Di Marcotullio L; Ghirga F
Eur J Med Chem; 2018 Aug; 156():554-562. PubMed ID: 30025349
[TBL] [Abstract][Full Text] [Related]
32. scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy.
Ocasio JK; Babcock B; Malawsky D; Weir SJ; Loo L; Simon JM; Zylka MJ; Hwang D; Dismuke T; Sokolsky M; Rosen EP; Vibhakar R; Zhang J; Saulnier O; Vladoiu M; El-Hamamy I; Stein LD; Taylor MD; Smith KS; Northcott PA; Colaneri A; Wilhelmsen K; Gershon TR
Nat Commun; 2019 Dec; 10(1):5829. PubMed ID: 31863004
[TBL] [Abstract][Full Text] [Related]
33. Inhibition of the FACT Complex Targets Aberrant Hedgehog Signaling and Overcomes Resistance to Smoothened Antagonists.
Mo J; Liu F; Sun X; Huang H; Tan K; Zhao X; Li R; Jiang W; Sui Y; Chen X; Shen K; Zhang L; Ma J; Zhao K; Tang Y
Cancer Res; 2021 Jun; 81(11):3105-3120. PubMed ID: 33853831
[TBL] [Abstract][Full Text] [Related]
34. Hedgehog pathway permissive conditions allow generation of immortal cell lines from granule cells derived from cancerous and non-cancerous cerebellum.
Heil C
Open Biol; 2019 Jan; 9(1):180145. PubMed ID: 30958113
[TBL] [Abstract][Full Text] [Related]
35. Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.
Faria CC; Golbourn BJ; Dubuc AM; Remke M; Diaz RJ; Agnihotri S; Luck A; Sabha N; Olsen S; Wu X; Garzia L; Ramaswamy V; Mack SC; Wang X; Leadley M; Reynaud D; Ermini L; Post M; Northcott PA; Pfister SM; Croul SE; Kool M; Korshunov A; Smith CA; Taylor MD; Rutka JT
Cancer Res; 2015 Jan; 75(1):134-46. PubMed ID: 25391241
[TBL] [Abstract][Full Text] [Related]
36. Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma.
Aiello G; Ballabio C; Ruggeri R; Fagnocchi L; Anderle M; Morassut I; Caron D; Garilli F; Gianno F; Giangaspero F; Piazza S; Romanel A; Zippo A; Tiberi L
Cell Rep; 2019 Dec; 29(12):4036-4052.e10. PubMed ID: 31851932
[TBL] [Abstract][Full Text] [Related]
37. Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.
Li S; Li S; Han Y; Tong C; Wang B; Chen Y; Jiang J
PLoS Biol; 2016 Jun; 14(6):e1002481. PubMed ID: 27280464
[TBL] [Abstract][Full Text] [Related]
38. Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma.
Rodriguez-Blanco J; Pednekar L; Penas C; Li B; Martin V; Long J; Lee E; Weiss WA; Rodriguez C; Mehrdad N; Nguyen DM; Ayad NG; Rai P; Capobianco AJ; Robbins DJ
Oncogene; 2017 Nov; 36(45):6306-6314. PubMed ID: 28714964
[TBL] [Abstract][Full Text] [Related]
39. Cooperation between Shh and IGF-I in promoting myogenic proliferation and differentiation via the MAPK/ERK and PI3K/Akt pathways requires Smo activity.
Madhala-Levy D; Williams VC; Hughes SM; Reshef R; Halevy O
J Cell Physiol; 2012 Apr; 227(4):1455-64. PubMed ID: 21618536
[TBL] [Abstract][Full Text] [Related]
40. Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.
Gordon RE; Zhang L; Peri S; Kuo YM; Du F; Egleston BL; Ng JMY; Andrews AJ; Astsaturov I; Curran T; Yang ZJ
Clin Cancer Res; 2018 Mar; 24(6):1375-1388. PubMed ID: 29437795
[No Abstract] [Full Text] [Related]
[Previous] [Next] [New Search]
