202 related articles for article (PubMed ID: 35419951)
41. RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.
Zhao X; Ponomaryov T; Ornell KJ; Zhou P; Dabral SK; Pak E; Li W; Atwood SX; Whitson RJ; Chang AL; Li J; Oro AE; Chan JA; Kelleher JF; Segal RA
Cancer Res; 2015 Sep; 75(17):3623-35. PubMed ID: 26130651
[TBL] [Abstract][Full Text] [Related]
42. Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression.
Milla LA; Arros A; Espinoza N; Remke M; Kool M; Taylor MD; Pfister SM; Wainwright BJ; Palma V
Int J Cancer; 2014 Jan; 134(1):21-31. PubMed ID: 23775842
[TBL] [Abstract][Full Text] [Related]
43. Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development.
Aref D; Moffatt CJ; Agnihotri S; Ramaswamy V; Dubuc AM; Northcott PA; Taylor MD; Perry A; Olson JM; Eberhart CG; Croul SE
Brain Pathol; 2013 Mar; 23(2):178-91. PubMed ID: 22966790
[TBL] [Abstract][Full Text] [Related]
44. The developmental stage of the medulloblastoma cell-of-origin restricts Sonic hedgehog pathway usage and drug sensitivity.
Smit MJ; Martini TEI; Armandari I; Bočkaj I; Zomerman WW; de Camargo Magalhães ES; Siragna Z; Meeuwsen TGJ; Scherpen FJG; Schoots MH; Ritsema M; den Dunnen WFA; Hoving EW; Paridaen JTML; de Haan G; Guryev V; Bruggeman SWM
J Cell Sci; 2022 Jun; 135(11):. PubMed ID: 35535520
[TBL] [Abstract][Full Text] [Related]
45. A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.
Dey J; Ditzler S; Knoblaugh SE; Hatton BA; Schelter JM; Cleary MA; Mecham B; Rorke-Adams LB; Olson JM
Mol Cell Biol; 2012 Oct; 32(20):4104-15. PubMed ID: 22869526
[TBL] [Abstract][Full Text] [Related]
46. SHH inhibitors for the treatment of medulloblastoma.
Samkari A; White J; Packer R
Expert Rev Neurother; 2015; 15(7):763-70. PubMed ID: 26027634
[TBL] [Abstract][Full Text] [Related]
47. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells.
Corcoran RB; Scott MP
Proc Natl Acad Sci U S A; 2006 May; 103(22):8408-13. PubMed ID: 16707575
[TBL] [Abstract][Full Text] [Related]
48. The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.
Northcott PA; Fernandez-L A; Hagan JP; Ellison DW; Grajkowska W; Gillespie Y; Grundy R; Van Meter T; Rutka JT; Croce CM; Kenney AM; Taylor MD
Cancer Res; 2009 Apr; 69(8):3249-55. PubMed ID: 19351822
[TBL] [Abstract][Full Text] [Related]
49. Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.
Li QR; Zhao H; Zhang XS; Lang H; Yu K
Acta Pharmacol Sin; 2019 Feb; 40(2):257-267. PubMed ID: 29777201
[TBL] [Abstract][Full Text] [Related]
50. The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.
Long J; Li B; Rodriguez-Blanco J; Pastori C; Volmar CH; Wahlestedt C; Capobianco A; Bai F; Pei XH; Ayad NG; Robbins DJ
J Biol Chem; 2014 Dec; 289(51):35494-502. PubMed ID: 25355313
[TBL] [Abstract][Full Text] [Related]
51. HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma.
Bell JB; Rink JS; Eckerdt F; Clymer J; Goldman S; Thaxton CS; Platanias LC
Sci Rep; 2018 Jan; 8(1):1211. PubMed ID: 29352211
[TBL] [Abstract][Full Text] [Related]
52. Principles of tumorigenesis and emerging molecular drivers of SHH-activated medulloblastomas.
Menyhárt O; Győrffy B
Ann Clin Transl Neurol; 2019 May; 6(5):990-1005. PubMed ID: 31139698
[TBL] [Abstract][Full Text] [Related]
53. ABT-199 inhibits Hedgehog pathway by acting as a competitive inhibitor of oxysterol, rather as a BH3 mimetic.
Wang J; Zhang Y; Huang WJ; Yang J; Tang WG; Huang TM; Tan WF
Acta Pharmacol Sin; 2021 Jun; 42(6):1005-1013. PubMed ID: 32855528
[TBL] [Abstract][Full Text] [Related]
54. YAP1 Is a Potential Predictive Molecular Biomarker for Response to SMO Inhibitor in Medulloblastoma Cells.
Alencastro Veiga Cruzeiro G; de Almeida Magalhães T; Ribeiro de Sousa G; Bonfim Silva R; Alberto Oliveira de Biagi Junior C; Ferreira das Chagas P; Gomes de Paula Queiroz R; Alberto Scrideli C; Gonzaga Tone L; Terci Valera E
Cancers (Basel); 2021 Dec; 13(24):. PubMed ID: 34944872
[TBL] [Abstract][Full Text] [Related]
55. Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.
Arensdorf AM; Dillard ME; Menke JM; Frank MW; Rock CO; Ogden SK
Cell Rep; 2017 Jun; 19(10):2074-2087. PubMed ID: 28591579
[TBL] [Abstract][Full Text] [Related]
56. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.
Vanner RJ; Remke M; Gallo M; Selvadurai HJ; Coutinho F; Lee L; Kushida M; Head R; Morrissy S; Zhu X; Aviv T; Voisin V; Clarke ID; Li Y; Mungall AJ; Moore RA; Ma Y; Jones SJ; Marra MA; Malkin D; Northcott PA; Kool M; Pfister SM; Bader G; Hochedlinger K; Korshunov A; Taylor MD; Dirks PB
Cancer Cell; 2014 Jul; 26(1):33-47. PubMed ID: 24954133
[TBL] [Abstract][Full Text] [Related]
57. Medulloblastoma: Molecular understanding, treatment evolution, and new developments.
Liu X; Ding C; Tan W; Zhang A
Pharmacol Ther; 2020 Jun; 210():107516. PubMed ID: 32105673
[TBL] [Abstract][Full Text] [Related]
58. Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli.
Li XY; Zhou LF; Gao LJ; Wei Y; Xu SF; Chen FY; Huang WJ; Tan WF; Ye YP
Cancer Lett; 2018 Apr; 420():195-207. PubMed ID: 29425683
[TBL] [Abstract][Full Text] [Related]
59. DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.
Gruber W; Hutzinger M; Elmer DP; Parigger T; Sternberg C; Cegielkowski L; Zaja M; Leban J; Michel S; Hamm S; Vitt D; Aberger F
Oncotarget; 2016 Feb; 7(6):7134-48. PubMed ID: 26784250
[TBL] [Abstract][Full Text] [Related]
60. Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments.
Jeng KS; Chang CF; Lin SS
Int J Mol Sci; 2020 Jan; 21(3):. PubMed ID: 31979397
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]