149 related articles for article (PubMed ID: 35440108)
1. Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.
Savill KMZ; Lee BB; Oeh J; Lin J; Lin E; Chung WJ; Young A; Chen W; Miś M; Mesh K; Eastham J; Gnad F; Jiang Z; Stawiski EW; Haley B; Daemen A; Wang X; Koeppen H; Modrusan Z; Martin SE; Sampath D; Lin K
Nat Commun; 2022 Apr; 13(1):2057. PubMed ID: 35440108
[TBL] [Abstract][Full Text] [Related]
2. Inhibitors in AKTion: ATP-competitive vs allosteric.
Lazaro G; Kostaras E; Vivanco I
Biochem Soc Trans; 2020 Jun; 48(3):933-943. PubMed ID: 32453400
[TBL] [Abstract][Full Text] [Related]
3. Akt Pathway Inhibitors.
Uko NE; Güner OF; Matesic DF; Bowen JP
Curr Top Med Chem; 2020; 20(10):883-900. PubMed ID: 32091335
[TBL] [Abstract][Full Text] [Related]
4. The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors.
Lindsley CW; Barnett SF; Layton ME; Bilodeau MT
Curr Cancer Drug Targets; 2008 Feb; 8(1):7-18. PubMed ID: 18288939
[TBL] [Abstract][Full Text] [Related]
5. A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors.
Saura C; Roda D; Roselló S; Oliveira M; Macarulla T; Pérez-Fidalgo JA; Morales-Barrera R; Sanchis-García JM; Musib L; Budha N; Zhu J; Nannini M; Chan WY; Sanabria Bohórquez SM; Meng RD; Lin K; Yan Y; Patel P; Baselga J; Tabernero J; Cervantes A
Cancer Discov; 2017 Jan; 7(1):102-113. PubMed ID: 27872130
[TBL] [Abstract][Full Text] [Related]
6. Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors.
Ewald F; Nörz D; Grottke A; Hofmann BT; Nashan B; Jücker M
Invest New Drugs; 2014 Dec; 32(6):1144-54. PubMed ID: 25152244
[TBL] [Abstract][Full Text] [Related]
7. Developments in selective small molecule ATP-targeting the serine/threonine kinase Akt/PKB.
Wang P; Zhang L; Hao Q; Zhao G
Mini Rev Med Chem; 2011 Nov; 11(13):1093-107. PubMed ID: 22353219
[TBL] [Abstract][Full Text] [Related]
8. ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1.
Shaw AL; Parson MAH; Truebestein L; Jenkins ML; Leonard TA; Burke JE
Structure; 2023 Mar; 31(3):343-354.e3. PubMed ID: 36758543
[TBL] [Abstract][Full Text] [Related]
9. Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises.
Pervanidis KA; D'Angelo GD; Weisner J; Brandherm S; Rauh D
J Med Chem; 2024 Apr; 67(8):6052-6063. PubMed ID: 38592948
[TBL] [Abstract][Full Text] [Related]
10. A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.
Kostaras E; Kaserer T; Lazaro G; Heuss SF; Hussain A; Casado P; Hayes A; Yandim C; Palaskas N; Yu Y; Schwartz B; Raynaud F; Chung YL; Cutillas PR; Vivanco I
Br J Cancer; 2020 Aug; 123(4):542-555. PubMed ID: 32439931
[TBL] [Abstract][Full Text] [Related]
11. Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors.
Lindsley CW; Barnett SF; Yaroschak M; Bilodeau MT; Layton ME
Curr Top Med Chem; 2007; 7(14):1349-63. PubMed ID: 17692025
[TBL] [Abstract][Full Text] [Related]
12. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.
Dumble M; Crouthamel MC; Zhang SY; Schaber M; Levy D; Robell K; Liu Q; Figueroa DJ; Minthorn EA; Seefeld MA; Rouse MB; Rabindran SK; Heerding DA; Kumar R
PLoS One; 2014; 9(6):e100880. PubMed ID: 24978597
[TBL] [Abstract][Full Text] [Related]
13. Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models.
Cocco S; Leone A; Roca MS; Lombardi R; Piezzo M; Caputo R; Ciardiello C; Costantini S; Bruzzese F; Sisalli MJ; Budillon A; De Laurentiis M
J Transl Med; 2022 Jun; 20(1):290. PubMed ID: 35761360
[TBL] [Abstract][Full Text] [Related]
14. Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-κB directly regulates PUMA-dependent apoptosis.
Sun L; Huang Y; Liu Y; Zhao Y; He X; Zhang L; Wang F; Zhang Y
Cell Death Dis; 2018 Sep; 9(9):911. PubMed ID: 30185800
[TBL] [Abstract][Full Text] [Related]
15. Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.
Liu Q; Xu C; Kirubakaran S; Zhang X; Hur W; Liu Y; Kwiatkowski NP; Wang J; Westover KD; Gao P; Ercan D; Niepel M; Thoreen CC; Kang SA; Patricelli MP; Wang Y; Tupper T; Altabef A; Kawamura H; Held KD; Chou DM; Elledge SJ; Janne PA; Wong KK; Sabatini DM; Gray NS
Cancer Res; 2013 Apr; 73(8):2574-86. PubMed ID: 23436801
[TBL] [Abstract][Full Text] [Related]
16. Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.
Yamaji M; Ota A; Wahiduzzaman M; Karnan S; Hyodo T; Konishi H; Tsuzuki S; Hosokawa Y; Haniuda M
Cancer Med; 2017 Nov; 6(11):2646-2659. PubMed ID: 28960945
[TBL] [Abstract][Full Text] [Related]
17. Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer - A comprehensive review from chemotherapy to immunotherapy.
Jabbarzadeh Kaboli P; Salimian F; Aghapour S; Xiang S; Zhao Q; Li M; Wu X; Du F; Zhao Y; Shen J; Cho CH; Xiao Z
Pharmacol Res; 2020 Jun; 156():104806. PubMed ID: 32294525
[TBL] [Abstract][Full Text] [Related]
18. Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells.
Dong J; Zhai B; Sun W; Hu F; Cheng H; Xu J
PLoS One; 2017; 12(9):e0185088. PubMed ID: 28934275
[TBL] [Abstract][Full Text] [Related]
19. Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer.
Yang F; Deng R; Qian XJ; Chang SH; Wu XQ; Qin J; Feng GK; Ding K; Zhu XF
Cell Death Dis; 2014 Mar; 5(3):e1114. PubMed ID: 24625973
[TBL] [Abstract][Full Text] [Related]
20. AKT as a therapeutic target in multiple myeloma.
Keane NA; Glavey SV; Krawczyk J; O'Dwyer M
Expert Opin Ther Targets; 2014 Aug; 18(8):897-915. PubMed ID: 24905897
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
