BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 35453395)

  • 1. Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin.
    Yang Y; Sun S; Xu W; Zhang Y; Yang R; Ma K; Zhang J; Xu J
    Antioxidants (Basel); 2022 Apr; 11(4):. PubMed ID: 35453395
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer.
    Zou P; Xia Y; Ji J; Chen W; Zhang J; Chen X; Rajamanickam V; Chen G; Wang Z; Chen L; Wang Y; Yang S; Liang G
    Cancer Lett; 2016 May; 375(1):114-126. PubMed ID: 26963494
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec
    Liu M; Sun S; Meng Y; Wang L; Liu H; Shi W; Zhang Q; Xu W; Sun B; Xu J
    Molecules; 2023 Sep; 28(19):. PubMed ID: 37836684
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification.
    Iverson SV; Eriksson S; Xu J; Prigge JR; Talago EA; Meade TA; Meade ES; Capecchi MR; Arnér ES; Schmidt EE
    Free Radic Biol Med; 2013 Oct; 63():369-80. PubMed ID: 23743293
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Menadione inhibits thioredoxin reductase 1 via arylation at the Sec
    Sun S; Xu W; Zhang Y; Yang Y; Ma Q; Xu J
    Free Radic Biol Med; 2021 Aug; 172():482-489. PubMed ID: 34186208
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress.
    Zhang Q; Chen W; Lv X; Weng Q; Chen M; Cui R; Liang G; Ji J
    Front Pharmacol; 2019; 10():1180. PubMed ID: 31680962
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
    Stafford WC; Peng X; Olofsson MH; Zhang X; Luci DK; Lu L; Cheng Q; Trésaugues L; Dexheimer TS; Coussens NP; Augsten M; Ahlzén HM; Orwar O; Östman A; Stone-Elander S; Maloney DJ; Jadhav A; Simeonov A; Linder S; Arnér ESJ
    Sci Transl Med; 2018 Feb; 10(428):. PubMed ID: 29444979
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chlorophyllin Inhibits Mammalian Thioredoxin Reductase 1 and Triggers Cancer Cell Death.
    Sun S; Zhang Y; Xu W; Zhang Y; Yang R; Guo J; Guan S; Ma Q; Ma K; Xu J
    Antioxidants (Basel); 2021 Oct; 10(11):. PubMed ID: 34829604
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Plumbagin reduction by thioredoxin reductase 1 possesses synergy effects with GLUT1 inhibitor on KEAP1-mutant NSCLC cells.
    Sun S; Zhang Y; Xu W; Yang R; Yang Y; Guo J; Ma Q; Ma K; Zhang J; Xu J
    Biomed Pharmacother; 2022 Feb; 146():112546. PubMed ID: 34954641
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine.
    Anestål K; Arnér ES
    J Biol Chem; 2003 May; 278(18):15966-72. PubMed ID: 12574159
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Thioredoxin reductase 1 inhibitor shikonin promotes cell necroptosis via SecTRAPs generation and oxygen-coupled redox cycling.
    Zhang Y; Sun S; Xu W; Yang R; Yang Y; Guo J; Ma K; Xu J
    Free Radic Biol Med; 2022 Feb; 180():52-62. PubMed ID: 34973363
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase.
    Li J; Zuo X; Cheng P; Ren X; Sun S; Xu J; Holmgren A; Lu J
    Metallomics; 2019 Sep; 11(9):1490-1497. PubMed ID: 31359011
    [TBL] [Abstract][Full Text] [Related]  

  • 13. TXNRD1: A Key Regulator Involved in the Ferroptosis of CML Cells Induced by Cysteine Depletion In Vitro.
    Liu S; Wu W; Chen Q; Zheng Z; Jiang X; Xue Y; Lin D
    Oxid Med Cell Longev; 2021; 2021():7674565. PubMed ID: 34917232
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1.
    Prigge JR; Eriksson S; Iverson SV; Meade TA; Capecchi MR; Arnér ES; Schmidt EE
    Free Radic Biol Med; 2012 Feb; 52(4):803-10. PubMed ID: 22198266
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.
    Shi W; Sun S; Liu H; Meng Y; Ren K; Wang G; Liu M; Wu J; Zhang Y; Huang H; Shi M; Xu W; Ma Q; Sun B; Xu J
    Redox Biol; 2024 Apr; 70():103050. PubMed ID: 38277963
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Acetaminophen reactive intermediates target hepatic thioredoxin reductase.
    Jan YH; Heck DE; Dragomir AC; Gardner CR; Laskin DL; Laskin JD
    Chem Res Toxicol; 2014 May; 27(5):882-94. PubMed ID: 24661219
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells.
    Zhang P; Shi L; Zhang T; Hong L; He W; Cao P; Shen X; Zheng P; Xia Y; Zou P
    Cell Oncol (Dordr); 2019 Dec; 42(6):847-860. PubMed ID: 31493144
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase.
    Gencheva R; Cheng Q; Arnér ESJ
    Biochim Biophys Acta Gen Subj; 2018 Nov; 1862(11):2511-2517. PubMed ID: 29807072
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Thioredoxin Reductase Inhibition for Cancer Therapy.
    Gencheva R; Arnér ESJ
    Annu Rev Pharmacol Toxicol; 2022 Jan; 62():177-196. PubMed ID: 34449246
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells.
    Tanaka G; Inoue K; Shimizu T; Akimoto K; Kubota K
    Cancer Med; 2016 Sep; 5(9):2544-57. PubMed ID: 27485632
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.