These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

278 related articles for article (PubMed ID: 35458759)

  • 1. Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases.
    Brogi S; Ibba R; Rossi S; Butini S; Calderone V; Gemma S; Campiani G
    Molecules; 2022 Apr; 27(8):. PubMed ID: 35458759
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB.
    Schröder J; Noack S; Marhöfer RJ; Mottram JC; Coombs GH; Selzer PM
    PLoS One; 2013; 8(10):e77460. PubMed ID: 24146999
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?
    Cianni L; Feldmann CW; Gilberg E; Gütschow M; Juliano L; Leitão A; Bajorath J; Montanari CA
    J Med Chem; 2019 Dec; 62(23):10497-10525. PubMed ID: 31361135
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A comparative study of warheads for design of cysteine protease inhibitors.
    Silva DG; Ribeiro JFR; De Vita D; Cianni L; Franco CH; Freitas-Junior LH; Moraes CB; Rocha JR; Burtoloso ACB; Kenny PW; Leitão A; Montanari CA
    Bioorg Med Chem Lett; 2017 Nov; 27(22):5031-5035. PubMed ID: 29054358
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles.
    Dos Santos AM; Cianni L; De Vita D; Rosini F; Leitão A; Laughton CA; Lameira J; Montanari CA
    Phys Chem Chem Phys; 2018 Sep; 20(37):24317-24328. PubMed ID: 30211406
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease.
    Nicoll-Griffith DA
    Expert Opin Drug Discov; 2012 Apr; 7(4):353-66. PubMed ID: 22458506
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Substitution-Induced Mechanistic Switching in S
    Zimmer C; Brauer J; Ferenc D; Meyr J; Müller P; Räder HJ; Engels B; Opatz T; Schirmeister T
    Molecules; 2024 Jun; 29(11):. PubMed ID: 38893535
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor.
    Ribeiro JFR; Cianni L; Li C; Warwick TG; de Vita D; Rosini F; Dos Reis Rocho F; Martins FCP; Kenny PW; Lameira J; Leitão A; Emsley J; Montanari CA
    Bioorg Med Chem; 2020 Nov; 28(22):115743. PubMed ID: 33038787
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism.
    Silva JRA; Cianni L; Araujo D; Batista PHJ; de Vita D; Rosini F; Leitão A; Lameira J; Montanari CA
    J Chem Inf Model; 2020 Mar; 60(3):1666-1677. PubMed ID: 32126170
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds.
    Oballa RM; Truchon JF; Bayly CI; Chauret N; Day S; Crane S; Berthelette C
    Bioorg Med Chem Lett; 2007 Feb; 17(4):998-1002. PubMed ID: 17157022
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Nitrile-based peptoids as cysteine protease inhibitors.
    Alves L; Santos DA; Cendron R; Rocho FR; Matos TKB; Leitão A; Montanari CA
    Bioorg Med Chem; 2021 Jul; 41():116211. PubMed ID: 33991733
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors-A Comprehensive Reactivity and Selectivity Study.
    Müller P; Meta M; Meidner JL; Schwickert M; Meyr J; Schwickert K; Kersten C; Zimmer C; Hammerschmidt SJ; Frey A; Lahu A; de la Hoz-Rodríguez S; Agost-Beltrán L; Rodríguez S; Diemer K; Neumann W; Gonzàlez FV; Engels B; Schirmeister T
    Int J Mol Sci; 2023 Apr; 24(8):. PubMed ID: 37108388
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterising covalent warhead reactivity.
    Martin JS; MacKenzie CJ; Fletcher D; Gilbert IH
    Bioorg Med Chem; 2019 May; 27(10):2066-2074. PubMed ID: 30975501
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rhenium(V) Complexes as Cysteine-Targeting Coordinate Covalent Warheads.
    Karges J; Cohen SM
    J Med Chem; 2023 Feb; 66(4):3088-3105. PubMed ID: 36752718
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L.
    Ehmke V; Winkler E; Banner DW; Haap W; Schweizer WB; Rottmann M; Kaiser M; Freymond C; Schirmeister T; Diederich F
    ChemMedChem; 2013 Jun; 8(6):967-75. PubMed ID: 23658062
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
    Yang PY; Wang M; Li L; Wu H; He CY; Yao SQ
    Chemistry; 2012 May; 18(21):6528-41. PubMed ID: 22488888
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evaluating QM/MM Free Energy Surfaces for Ranking Cysteine Protease Covalent Inhibitors.
    da Costa CHS; Bonatto V; Dos Santos AM; Lameira J; Leitão A; Montanari CA
    J Chem Inf Model; 2020 Feb; 60(2):880-889. PubMed ID: 31944110
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Drug Discovery Efforts to Identify Novel Treatments for Neglected Tropical Diseases - Cysteine Protease Inhibitors.
    Giroud M; Kuhn B; Haap W
    Curr Med Chem; 2024; 31(16):2170-2194. PubMed ID: 37916489
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ensemble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE.
    Scala A; Rescifina A; Micale N; Piperno A; Schirmeister T; Maes L; Grassi G
    Chem Biol Drug Des; 2018 Feb; 91(2):597-604. PubMed ID: 29045053
    [TBL] [Abstract][Full Text] [Related]  

  • 20. MD-Based Assessment of Covalent Inhibitors in Noncovalent Association Complexes: Learning from Cathepsin K as a Test Case.
    Endres E; Yuan Chen N; Sotriffer C
    J Chem Inf Model; 2023 May; 63(10):3186-3197. PubMed ID: 37165835
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.