BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

297 related articles for article (PubMed ID: 35468792)

  • 1. Engineered Cas12a-Plus nuclease enables gene editing with enhanced activity and specificity.
    Huang H; Huang G; Tan Z; Hu Y; Shan L; Zhou J; Zhang X; Ma S; Lv W; Huang T; Liu Y; Wang D; Zhao X; Lin Y; Rong Z
    BMC Biol; 2022 Apr; 20(1):91. PubMed ID: 35468792
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.
    Kleinstiver BP; Sousa AA; Walton RT; Tak YE; Hsu JY; Clement K; Welch MM; Horng JE; Malagon-Lopez J; Scarfò I; Maus MV; Pinello L; Aryee MJ; Joung JK
    Nat Biotechnol; 2019 Mar; 37(3):276-282. PubMed ID: 30742127
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High-Throughput Profiling of Cas12a Orthologues and Engineered Variants for Enhanced Genome Editing Activity.
    Zhu D; Wang J; Yang D; Xi J; Li J
    Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948095
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Acidaminococcus sp. Cas12a nuclease recognizes GTTV and GCTV as non-canonical PAMs.
    Jacobsen T; Liao C; Beisel CL
    FEMS Microbiol Lett; 2019 Apr; 366(8):. PubMed ID: 31004485
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Multiplexed conditional genome editing with Cas12a in
    Port F; Starostecka M; Boutros M
    Proc Natl Acad Sci U S A; 2020 Sep; 117(37):22890-22899. PubMed ID: 32843348
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects.
    Murugan K; Seetharam AS; Severin AJ; Sashital DG
    J Biol Chem; 2020 Apr; 295(17):5538-5553. PubMed ID: 32161115
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A Cas12a ortholog with stringent PAM recognition followed by low off-target editing rates for genome editing.
    Chen P; Zhou J; Wan Y; Liu H; Li Y; Liu Z; Wang H; Lei J; Zhao K; Zhang Y; Wang Y; Zhang X; Yin L
    Genome Biol; 2020 Mar; 21(1):78. PubMed ID: 32213191
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Expanding the range of editable targets in the wheat genome using the variants of the Cas12a and Cas9 nucleases.
    Wang W; Tian B; Pan Q; Chen Y; He F; Bai G; Akhunova A; Trick HN; Akhunov E
    Plant Biotechnol J; 2021 Dec; 19(12):2428-2441. PubMed ID: 34270168
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Assessment of Cas12a-mediated gene editing efficiency in plants.
    Bernabé-Orts JM; Casas-Rodrigo I; Minguet EG; Landolfi V; Garcia-Carpintero V; Gianoglio S; Vázquez-Vilar M; Granell A; Orzaez D
    Plant Biotechnol J; 2019 Oct; 17(10):1971-1984. PubMed ID: 30950179
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A more efficient CRISPR-Cas12a variant derived from
    Tran MH; Park H; Nobles CL; Karunadharma P; Pan L; Zhong G; Wang H; He W; Ou T; Crynen G; Sheptack K; Stiskin I; Mou H; Farzan M
    Mol Ther Nucleic Acids; 2021 Jun; 24():40-53. PubMed ID: 33738137
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Comparison of Cas12a and Cas9-mediated mutagenesis in tomato cells.
    Slaman E; Kottenhagen L; de Martines W; Angenent GC; de Maagd RA
    Sci Rep; 2024 Feb; 14(1):4508. PubMed ID: 38402312
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Application of CRISPR-Cas12a temperature sensitivity for improved genome editing in rice, maize, and Arabidopsis.
    Malzahn AA; Tang X; Lee K; Ren Q; Sretenovic S; Zhang Y; Chen H; Kang M; Bao Y; Zheng X; Deng K; Zhang T; Salcedo V; Wang K; Zhang Y; Qi Y
    BMC Biol; 2019 Jan; 17(1):9. PubMed ID: 30704461
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Highly Efficient Genome Editing in Plant Protoplasts by Ribonucleoprotein Delivery of CRISPR-Cas12a Nucleases.
    Zhang Y; Cheng Y; Fang H; Roberts N; Zhang L; Vakulskas CA; Niedz RP; Culver JN; Qi Y
    Front Genome Ed; 2022; 4():780238. PubMed ID: 35174354
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Engineering of Cas12a nuclease variants with enhanced genome-editing specificity.
    Chen P; Zhou J; Liu H; Zhou E; He B; Wu Y; Wang H; Sun Z; Paek C; Lei J; Chen Y; Zhang X; Yin L
    PLoS Biol; 2024 Mar; 22(3):e3002514. PubMed ID: 38483978
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Efficient Genome Editing in
    An Y; Geng Y; Yao J; Fu C; Lu M; Wang C; Du J
    Front Plant Sci; 2020; 11():593938. PubMed ID: 33329659
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Deciphering the Substrate Specificity Reveals that CRISPR-Cas12a Is a Bifunctional Enzyme with Both Endo- and Exonuclease Activities.
    Bhattacharya S; Agarwal A; Muniyappa K
    J Mol Biol; 2024 May; 436(10):168550. PubMed ID: 38575054
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Efficient multiplex CRISPR/Cpf1 (Cas12a) genome editing system in Aspergillus aculeatus TBRC 277.
    Abdulrachman D; Champreda V; Eurwilaichitr L; Chantasingh D; Pootanakit K
    J Biotechnol; 2022 Aug; 355():53-64. PubMed ID: 35788357
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates.
    Ling X; Chang L; Chen H; Gao X; Yin J; Zuo Y; Huang Y; Zhang B; Hu J; Liu T
    Mol Cell; 2021 Nov; 81(22):4747-4756.e7. PubMed ID: 34648747
    [TBL] [Abstract][Full Text] [Related]  

  • 19. AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines.
    Zhang L; Zuris JA; Viswanathan R; Edelstein JN; Turk R; Thommandru B; Rube HT; Glenn SE; Collingwood MA; Bode NM; Beaudoin SF; Lele S; Scott SN; Wasko KM; Sexton S; Borges CM; Schubert MS; Kurgan GL; McNeill MS; Fernandez CA; Myer VE; Morgan RA; Behlke MA; Vakulskas CA
    Nat Commun; 2021 Jun; 12(1):3908. PubMed ID: 34162850
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Direct observation of DNA target searching and cleavage by CRISPR-Cas12a.
    Jeon Y; Choi YH; Jang Y; Yu J; Goo J; Lee G; Jeong YK; Lee SH; Kim IS; Kim JS; Jeong C; Lee S; Bae S
    Nat Commun; 2018 Jul; 9(1):2777. PubMed ID: 30018371
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.