124 related articles for article (PubMed ID: 35507041)
1. Dose-dependent bioavailability, absorption-rate limited elimination, and tissue distribution of the ATR inhibitor BAY-1895344 (elimusertib) in mice.
Kiesel BF; Deppas JJ; Guo J; Parise RA; Clump DA; Bakkenist CJ; Beumer JH
Cancer Chemother Pharmacol; 2022 Jun; 89(6):795-807. PubMed ID: 35507041
[TBL] [Abstract][Full Text] [Related]
2. Dose-dependent bioavailability and tissue distribution of the ATR inhibitor AZD6738 (ceralasertib) in mice.
Kiesel BF; Guo J; Parise RA; Venkataramanan R; Clump DA; Bakkenist CJ; Beumer JH
Cancer Chemother Pharmacol; 2022 Feb; 89(2):231-242. PubMed ID: 35066692
[TBL] [Abstract][Full Text] [Related]
3. Quantitation of the ataxia-telangiectasia-mutated and Rad3-related inhibitor elimusertib (BAY-1895344) in human plasma using LC-MS/MS.
Kiesel BF; Parise RA; Krishnamurthy A; Gore S; Beumer JH
Biomed Chromatogr; 2022 Nov; 36(11):e5455. PubMed ID: 35876841
[TBL] [Abstract][Full Text] [Related]
4. Ovarian and uterine carcinosarcomas are sensitive in vitro and in vivo to elimusertib, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor.
Manavella DD; McNamara B; Harold J; Bellone S; Hartwich TMP; Yang-Hartwich Y; Mutlu L; Zipponi M; Demirkiran C; Verzosa MS; Altwerger G; Ratner E; Huang GS; Clark M; Andikyan V; Azodi M; Schwartz PE; Dottino PR; Choi J; Alexandrov LB; Buza N; Hui P; Santin AD
Gynecol Oncol; 2023 Feb; 169():98-105. PubMed ID: 36525930
[TBL] [Abstract][Full Text] [Related]
5. Evaluation of [
Carlucci G; Carney B; Sadique A; Vansteene A; Tang J; Reiner T
Nucl Med Biol; 2017 May; 48():9-15. PubMed ID: 28157626
[TBL] [Abstract][Full Text] [Related]
6. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.
Foote KM; Nissink JWM; McGuire T; Turner P; Guichard S; Yates JWT; Lau A; Blades K; Heathcote D; Odedra R; Wilkinson G; Wilson Z; Wood CM; Jewsbury PJ
J Med Chem; 2018 Nov; 61(22):9889-9907. PubMed ID: 30346772
[TBL] [Abstract][Full Text] [Related]
7. The ATR inhibitor elimusertib exhibits anti-lymphoma activity and synergizes with the PI3K inhibitor copanlisib.
Sartori G; Tarantelli C; Spriano F; Gaudio E; Cascione L; Mascia M; Barreca M; Arribas AJ; Licenziato L; Golino G; Ferragamo A; Pileri S; Damia G; Zucca E; Stathis A; Politz O; Wengner AM; Bertoni F
Br J Haematol; 2024 Jan; 204(1):191-205. PubMed ID: 38011941
[TBL] [Abstract][Full Text] [Related]
8. Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects.
Graham RA; Hop CE; Borin MT; Lum BL; Colburn D; Chang I; Shin YG; Malhi V; Low JA; Dresser MJ
Br J Clin Pharmacol; 2012 Nov; 74(5):788-96. PubMed ID: 22458643
[TBL] [Abstract][Full Text] [Related]
9. LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.
Kiesel BF; Scemama J; Parise RA; Villaruz L; Iffland A; Doyle A; Ivy P; Chu E; Bakkenist CJ; Beumer JH
J Pharm Biomed Anal; 2017 Nov; 146():244-250. PubMed ID: 28888173
[TBL] [Abstract][Full Text] [Related]
10. Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models.
Lücking U; Wortmann L; Wengner AM; Lefranc J; Lienau P; Briem H; Siemeister G; Bömer U; Denner K; Schäfer M; Koppitz M; Eis K; Bartels F; Bader B; Bone W; Moosmayer D; Holton SJ; Eberspächer U; Grudzinska-Goebel J; Schatz C; Deeg G; Mumberg D; von Nussbaum F
J Med Chem; 2020 Jul; 63(13):7293-7325. PubMed ID: 32502336
[TBL] [Abstract][Full Text] [Related]
11. The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models.
Wengner AM; Siemeister G; Lücking U; Lefranc J; Wortmann L; Lienau P; Bader B; Bömer U; Moosmayer D; Eberspächer U; Golfier S; Schatz CA; Baumgart SJ; Haendler B; Lejeune P; Schlicker A; von Nussbaum F; Brands M; Ziegelbauer K; Mumberg D
Mol Cancer Ther; 2020 Jan; 19(1):26-38. PubMed ID: 31582533
[TBL] [Abstract][Full Text] [Related]
12. The suppression of ATR/Chk1 pathway by Elimusertib ATR inhibitor in triple negative breast cancer cells.
Haciefendi A; Guney Eskiler G
Am J Transl Res; 2023; 15(7):4902-4911. PubMed ID: 37560219
[TBL] [Abstract][Full Text] [Related]
13. Preclinical Combination Studies of an FGFR2 Targeted Thorium-227 Conjugate and the ATR Inhibitor BAY 1895344.
Wickstroem K; Hagemann UB; Kristian A; Ellingsen C; Sommer A; Ellinger-Ziegelbauer H; Wirnitzer U; Hagelin EM; Larsen A; Smeets R; Bjerke RM; Karlsson J; Ryan OB; Wengner AM; Linden L; Mumberg D; Cuthbertson AS
Int J Radiat Oncol Biol Phys; 2019 Oct; 105(2):410-422. PubMed ID: 31255687
[TBL] [Abstract][Full Text] [Related]
14. Discovery of small-molecule ATR inhibitors for potential cancer treatment: a patent review from 2014 to present.
Hu S; Hui Z; Duan J; Garrido C; Xie T; Ye XY
Expert Opin Ther Pat; 2022 Apr; 32(4):401-421. PubMed ID: 35001778
[TBL] [Abstract][Full Text] [Related]
15. Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats.
Egorin MJ; Lagattuta TF; Hamburger DR; Covey JM; White KD; Musser SM; Eiseman JL
Cancer Chemother Pharmacol; 2002 Jan; 49(1):7-19. PubMed ID: 11855755
[TBL] [Abstract][Full Text] [Related]
16. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.
Vendetti FP; Lau A; Schamus S; Conrads TP; O'Connor MJ; Bakkenist CJ
Oncotarget; 2015 Dec; 6(42):44289-305. PubMed ID: 26517239
[TBL] [Abstract][Full Text] [Related]
17. Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types.
Terranova N; Jansen M; Falk M; Hendriks BS
Cancer Chemother Pharmacol; 2021 Feb; 87(2):185-196. PubMed ID: 33145616
[TBL] [Abstract][Full Text] [Related]
18. RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors.
Roulston A; Zimmermann M; Papp R; Skeldon A; Pellerin C; Dumas-Bérube É; Dumais V; Dorich S; Fader LD; Fournier S; Li L; Leclaire ME; Yin SY; Chefson A; Alam H; Yang W; Fugère-Desjardins C; Vignini-Hammond S; Skorey K; Mulani A; Rimkunas V; Veloso A; Hamel M; Stocco R; Mamane Y; Li Z; Young JTF; Zinda M; Black WC
Mol Cancer Ther; 2022 Feb; 21(2):245-256. PubMed ID: 34911817
[TBL] [Abstract][Full Text] [Related]
19. Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition.
Sundararajan V; Tan TZ; Lim D; Peng Y; Wengner AM; Ngoi NYL; Jeyasekharan AD; Tan DSP
J Pathol; 2023 Feb; 259(2):194-204. PubMed ID: 36373784
[TBL] [Abstract][Full Text] [Related]
20. ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.
Hall-Jackson CA; Cross DA; Morrice N; Smythe C
Oncogene; 1999 Nov; 18(48):6707-13. PubMed ID: 10597277
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
