These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

508 related articles for article (PubMed ID: 35525236)

  • 1. α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation.
    Chen JY; Zhu Q; Cai CZ; Luo HB; Lu JH
    Phytomedicine; 2022 Jul; 101():154125. PubMed ID: 35525236
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models.
    Zhu Q; Zhuang XX; Chen JY; Yuan NN; Chen Y; Cai CZ; Tan JQ; Su HX; Lu JH
    Phytomedicine; 2021 Jul; 87():153578. PubMed ID: 34038839
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation.
    Cai CZ; Zhou HF; Yuan NN; Wu MY; Lee SM; Ren JY; Su HX; Lu JJ; Chen XP; Li M; Tan JQ; Lu JH
    Phytomedicine; 2019 Aug; 61():152842. PubMed ID: 31048127
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson's Disease Models.
    Zhou H; Shao M; Guo B; Li C; Lu Y; Yang X; ShengnanLi ; Li H; Zhu Q; Zhong H; Wang Y; Zhang Z; Lu J; Lee SM
    Neurotherapeutics; 2019 Oct; 16(4):1225-1236. PubMed ID: 31313223
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein.
    Zhong J; Li M; Xu J; Dong W; Qin Y; Qiu S; Li X; Wang H
    Toxicol Appl Pharmacol; 2022 Feb; 436():115859. PubMed ID: 34990728
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.
    Pavia-Collado R; Cóppola-Segovia V; Miquel-Rio L; Alarcón-Aris D; Rodríguez-Aller R; Torres-López M; Paz V; Ruiz-Bronchal E; Campa L; Artigas F; Montefeltro A; Revilla R; Bortolozzi A
    Int J Mol Sci; 2021 Mar; 22(6):. PubMed ID: 33805843
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein.
    McKinnon C; De Snoo ML; Gondard E; Neudorfer C; Chau H; Ngana SG; O'Hara DM; Brotchie JM; Koprich JB; Lozano AM; Kalia LV; Kalia SK
    Acta Neuropathol Commun; 2020 Feb; 8(1):17. PubMed ID: 32059750
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.
    Castro-Sánchez S; García-Yagüe ÁJ; López-Royo T; Casarejos M; Lanciego JL; Lastres-Becker I
    Glia; 2018 Aug; 66(8):1752-1762. PubMed ID: 29624735
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein.
    Lan DM; Liu FT; Zhao J; Chen Y; Wu JJ; Ding ZT; Yue ZY; Ren HM; Jiang YP; Wang J
    Neurochem Res; 2012 Sep; 37(9):2025-32. PubMed ID: 22707286
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin-Proteasome System Activation.
    Guo B; Zheng C; Cao J; Qiu X; Luo F; Li H; Lee SM; Yang X; Zhang G; Sun Y; Zhang Z; Wang Y
    Neuromolecular Med; 2024 Apr; 26(1):9. PubMed ID: 38568291
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome.
    Pan Z; Yu CW; Zhao C; Shao M; Yang X; Liang X; Li H; Lu Y; Ye Q; Chern JW; Lu J; Zhou H; Lee SM
    Toxicol Appl Pharmacol; 2023 Dec; 480():116745. PubMed ID: 37931757
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection
    Zhou H; Li S; Li C; Yang X; Li H; Zhong H; Lu JH; Lee SM
    Aging Dis; 2020 May; 11(3):559-574. PubMed ID: 32489702
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson's disease.
    Shen QQ; Jv XH; Ma XZ; Li C; Liu L; Jia WT; Qu L; Chen LL; Xie JX
    Acta Pharmacol Sin; 2024 Feb; 45(2):268-281. PubMed ID: 37674042
    [TBL] [Abstract][Full Text] [Related]  

  • 14. UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease.
    Tiwari S; Singh A; Gupta P; Singh S
    Cells; 2022 Nov; 11(23):. PubMed ID: 36497031
    [TBL] [Abstract][Full Text] [Related]  

  • 15. alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines.
    Martìn-Clemente B; Alvarez-Castelao B; Mayo I; Sierra AB; Dìaz V; Milán M; Fariñas I; Gómez-Isla T; Ferrer I; Castaño JG
    J Biol Chem; 2004 Dec; 279(51):52984-90. PubMed ID: 15466467
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn).
    Batelli S; Peverelli E; Rodilossi S; Forloni G; Albani D
    Neuroscience; 2011 Nov; 195(4):128-37. PubMed ID: 21906659
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.
    Tatenhorst L; Eckermann K; Dambeck V; Fonseca-Ornelas L; Walle H; Lopes da Fonseca T; Koch JC; Becker S; Tönges L; Bähr M; Outeiro TF; Zweckstetter M; Lingor P
    Acta Neuropathol Commun; 2016 Apr; 4():39. PubMed ID: 27101974
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model.
    Behere A; Thörnqvist PO; Winberg S; Ingelsson M; Bergström J; Ekmark-Lewén S
    J Neurosci Res; 2021 Oct; 99(10):2525-2539. PubMed ID: 34292621
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress.
    Kim S; Park JM; Moon J; Choi HJ
    Exp Neurol; 2014 Feb; 252():63-74. PubMed ID: 24252179
    [TBL] [Abstract][Full Text] [Related]  

  • 20. C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.
    McGlinchey RP; Lacy SM; Huffer KE; Tayebi N; Sidransky E; Lee JC
    J Biol Chem; 2019 Jun; 294(25):9973-9984. PubMed ID: 31092553
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 26.