251 related articles for article (PubMed ID: 35536216)
1. Delineating the RAS Conformational Landscape.
Parker MI; Meyer JE; Golemis EA; Dunbrack RL
Cancer Res; 2022 Jul; 82(13):2485-2498. PubMed ID: 35536216
[TBL] [Abstract][Full Text] [Related]
2. Mutation-Induced Impacts on the Switch Transformations of the GDP- and GTP-Bound K-Ras: Insights from Multiple Replica Gaussian Accelerated Molecular Dynamics and Free Energy Analysis.
Chen J; Zhang S; Wang W; Pang L; Zhang Q; Liu X
J Chem Inf Model; 2021 Apr; 61(4):1954-1969. PubMed ID: 33739090
[TBL] [Abstract][Full Text] [Related]
3. KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation.
Lu J; Bera AK; Gondi S; Westover KD
Biochemistry; 2018 Jan; 57(3):324-333. PubMed ID: 29235861
[TBL] [Abstract][Full Text] [Related]
4. Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by
Sharma AK; Pei J; Yang Y; Dyba M; Smith B; Rabara D; Larsen EK; Lightstone FC; Esposito D; Stephen AG; Wang B; Beltran PJ; Wallace E; Nissley DV; McCormick F; Maciag AE
J Biol Chem; 2024 Feb; 300(2):105650. PubMed ID: 38237681
[TBL] [Abstract][Full Text] [Related]
5. Mechanisms of isoform-specific residue influence on GTP-bound HRas, KRas, and NRas.
Volmar AY; Guterres H; Zhou H; Reid D; Pavlopoulos S; Makowski L; Mattos C
Biophys J; 2022 Oct; 121(19):3616-3629. PubMed ID: 35794829
[TBL] [Abstract][Full Text] [Related]
6. Conformational Dynamics Allows Sampling of an "Active-like" State by Oncogenic K-Ras-GDP.
Grudzien P; Jang H; Leschinsky N; Nussinov R; Gaponenko V
J Mol Biol; 2022 Sep; 434(17):167695. PubMed ID: 35752212
[TBL] [Abstract][Full Text] [Related]
7. Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele.
Zhang Y; Larraufie MH; Musavi L; Akkiraju H; Brown LM; Stockwell BR
Biochemistry; 2018 Feb; 57(8):1380-1389. PubMed ID: 29313669
[TBL] [Abstract][Full Text] [Related]
8. Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Johnson CW; Lin YJ; Reid D; Parker J; Pavlopoulos S; Dischinger P; Graveel C; Aguirre AJ; Steensma M; Haigis KM; Mattos C
Cell Rep; 2019 Aug; 28(6):1538-1550.e7. PubMed ID: 31390567
[TBL] [Abstract][Full Text] [Related]
9. An NMR comparison of the changes produced by different guanosine 5'-triphosphate analogs in wild-type and oncogenic mutant p21ras.
Miller AF; Halkides CJ; Redfield AG
Biochemistry; 1993 Jul; 32(29):7367-76. PubMed ID: 8338834
[TBL] [Abstract][Full Text] [Related]
10. Oncogenic G12D mutation alters local conformations and dynamics of K-Ras.
Vatansever S; Erman B; Gümüş ZH
Sci Rep; 2019 Aug; 9(1):11730. PubMed ID: 31409810
[TBL] [Abstract][Full Text] [Related]
11. Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein.
Matsumoto S; Taniguchi-Tamura H; Araki M; Kawamura T; Miyamoto R; Tsuda C; Shima F; Kumasaka T; Okuno Y; Kataoka T
Biochem Biophys Res Commun; 2021 Aug; 565():85-90. PubMed ID: 34102474
[TBL] [Abstract][Full Text] [Related]
12. In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis.
Gerber M; Goel S; Maitra R
Comput Biol Med; 2022 Feb; 141():105110. PubMed ID: 34920161
[TBL] [Abstract][Full Text] [Related]
13. Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants.
Muraoka S; Shima F; Araki M; Inoue T; Yoshimoto A; Ijiri Y; Seki N; Tamura A; Kumasaka T; Yamamoto M; Kataoka T
FEBS Lett; 2012 Jun; 586(12):1715-8. PubMed ID: 22584058
[TBL] [Abstract][Full Text] [Related]
14. Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics.
Mello LV; van Aalten DM; Findlay JB
Protein Eng; 1997 Apr; 10(4):381-7. PubMed ID: 9194162
[TBL] [Abstract][Full Text] [Related]
15. Differential dynamics of RAS isoforms in GDP- and GTP-bound states.
Kapoor A; Travesset A
Proteins; 2015 Jun; 83(6):1091-106. PubMed ID: 25846136
[TBL] [Abstract][Full Text] [Related]
16. Conformational transformation of switch domains in GDP/K-Ras induced by G13 mutants: An investigation through Gaussian accelerated molecular dynamics simulations and principal component analysis.
Chen J; Wang L; Wang W; Sun H; Pang L; Bao H
Comput Biol Med; 2021 Aug; 135():104639. PubMed ID: 34247129
[TBL] [Abstract][Full Text] [Related]
17. GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRAS
Bera AK; Lu J; Lu C; Li L; Gondi S; Yan W; Nelson A; Zhang G; Westover KD
Birth Defects Res; 2020 Jun; 112(10):708-717. PubMed ID: 32187889
[TBL] [Abstract][Full Text] [Related]
18. Revisiting the structural flexibility of the complex p21(ras)-GTP: the catalytic conformation of the molecular switch II.
Soares TA; Miller JH; Straatsma TP
Proteins; 2001 Dec; 45(4):297-312. PubMed ID: 11746677
[TBL] [Abstract][Full Text] [Related]
19. GTP-Bound N-Ras Conformational States and Substates Are Modulated by Membrane and Point Mutation.
Farcas A; Janosi L
Int J Mol Sci; 2024 Jan; 25(3):. PubMed ID: 38338709
[TBL] [Abstract][Full Text] [Related]
20. Ras protein abundance correlates with Ras isoform mutation patterns in cancer.
Hood FE; Sahraoui YM; Jenkins RE; Prior IA
Oncogene; 2023 Apr; 42(15):1224-1232. PubMed ID: 36864243
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]