219 related articles for article (PubMed ID: 35536676)
1. A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models.
Zhong Z; Harmston N; Wood KC; Madan B; Virshup DM
J Clin Invest; 2022 Jun; 132(12):. PubMed ID: 35536676
[TBL] [Abstract][Full Text] [Related]
2. PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers.
Zhong Z; Sepramaniam S; Chew XH; Wood K; Lee MA; Madan B; Virshup DM
Oncogene; 2019 Oct; 38(40):6662-6677. PubMed ID: 31391551
[TBL] [Abstract][Full Text] [Related]
3. Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Jiang X; Hao HX; Growney JD; Woolfenden S; Bottiglio C; Ng N; Lu B; Hsieh MH; Bagdasarian L; Meyer R; Smith TR; Avello M; Charlat O; Xie Y; Porter JA; Pan S; Liu J; McLaughlin ME; Cong F
Proc Natl Acad Sci U S A; 2013 Jul; 110(31):12649-54. PubMed ID: 23847203
[TBL] [Abstract][Full Text] [Related]
4. GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1.
Zhong Y; Wang Z; Fu B; Pan F; Yachida S; Dhara M; Albesiano E; Li L; Naito Y; Vilardell F; Cummings C; Martinelli P; Li A; Yonescu R; Ma Q; Griffin CA; Real FX; Iacobuzio-Donahue CA
PLoS One; 2011; 6(7):e22129. PubMed ID: 21811562
[TBL] [Abstract][Full Text] [Related]
5. Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers.
Yang Q; Qin T; An T; Wu H; Xu G; Xiang J; Lei K; Zhang S; Xia J; Su G; Wang D; Xue M; Kong L; Zhang W; Wu S; Li Y
Eur J Pharmacol; 2023 Apr; 945():175628. PubMed ID: 36858339
[TBL] [Abstract][Full Text] [Related]
6. Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.
Hermann PC; Sancho P; Cañamero M; Martinelli P; Madriles F; Michl P; Gress T; de Pascual R; Gandia L; Guerra C; Barbacid M; Wagner M; Vieira CR; Aicher A; Real FX; Sainz B; Heeschen C
Gastroenterology; 2014 Nov; 147(5):1119-33.e4. PubMed ID: 25127677
[TBL] [Abstract][Full Text] [Related]
7. The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition.
Yu J; Yusoff PAM; Woutersen DTJ; Goh P; Harmston N; Smits R; Epstein DM; Virshup DM; Madan B
Cancer Res; 2020 Dec; 80(24):5619-5632. PubMed ID: 33067269
[TBL] [Abstract][Full Text] [Related]
8. EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of
Patil S; Steuber B; Kopp W; Kari V; Urbach L; Wang X; Küffer S; Bohnenberger H; Spyropoulou D; Zhang Z; Versemann L; Bösherz MS; Brunner M; Gaedcke J; Ströbel P; Zhang JS; Neesse A; Ellenrieder V; Singh SK; Johnsen SA; Hessmann E
Cancer Res; 2020 Nov; 80(21):4620-4632. PubMed ID: 32907838
[TBL] [Abstract][Full Text] [Related]
9. The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.
Martinelli P; Madriles F; Cañamero M; Pau EC; Pozo ND; Guerra C; Real FX
Gut; 2016 Mar; 65(3):476-86. PubMed ID: 25596178
[TBL] [Abstract][Full Text] [Related]
10. PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.
Covey TM; Kaur S; Tan Ong T; Proffitt KD; Wu Y; Tan P; Virshup DM
PLoS One; 2012; 7(4):e34532. PubMed ID: 22509316
[TBL] [Abstract][Full Text] [Related]
11. Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand-Addicted Pancreatic Cancer.
Aguilera KY; Le T; Riahi R; Lay AR; Hinz S; Saadat EA; Vashisht AA; Wohlschlegel J; Donahue TR; Radu CG; Dawson DW
Mol Cancer Ther; 2022 Jun; 21(6):936-947. PubMed ID: 35313331
[TBL] [Abstract][Full Text] [Related]
12. Altering cancer transcriptomes using epigenomic inhibitors.
Gaddis M; Gerrard D; Frietze S; Farnham PJ
Epigenetics Chromatin; 2015; 8():9. PubMed ID: 26191083
[TBL] [Abstract][Full Text] [Related]
13. Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression.
Ogiwara H; Sasaki M; Mitachi T; Oike T; Higuchi S; Tominaga Y; Kohno T
Cancer Discov; 2016 Apr; 6(4):430-45. PubMed ID: 26603525
[TBL] [Abstract][Full Text] [Related]
14. Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.
Seino T; Kawasaki S; Shimokawa M; Tamagawa H; Toshimitsu K; Fujii M; Ohta Y; Matano M; Nanki K; Kawasaki K; Takahashi S; Sugimoto S; Iwasaki E; Takagi J; Itoi T; Kitago M; Kitagawa Y; Kanai T; Sato T
Cell Stem Cell; 2018 Mar; 22(3):454-467.e6. PubMed ID: 29337182
[TBL] [Abstract][Full Text] [Related]
15. Targeting Lineage-specific MITF Pathway in Human Melanoma Cell Lines by A-485, the Selective Small-molecule Inhibitor of p300/CBP.
Wang R; He Y; Robinson V; Yang Z; Hessler P; Lasko LM; Lu X; Bhathena A; Lai A; Uziel T; Lam LT
Mol Cancer Ther; 2018 Dec; 17(12):2543-2550. PubMed ID: 30266801
[TBL] [Abstract][Full Text] [Related]
16. Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.
Zhou X; Sun Z; Zhang M; Qu X; Yang S; Wang L; Jing Y; Li L; Deng W; Liu F; Di J; Chen J; Wu J; Zhang H
Animal Model Exp Med; 2022 Feb; 5(1):61-71. PubMed ID: 35229994
[TBL] [Abstract][Full Text] [Related]
17. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Steinhart Z; Pavlovic Z; Chandrashekhar M; Hart T; Wang X; Zhang X; Robitaille M; Brown KR; Jaksani S; Overmeer R; Boj SF; Adams J; Pan J; Clevers H; Sidhu S; Moffat J; Angers S
Nat Med; 2017 Jan; 23(1):60-68. PubMed ID: 27869803
[TBL] [Abstract][Full Text] [Related]
18. A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration.
Zhang Y; Goss AM; Cohen ED; Kadzik R; Lepore JJ; Muthukumaraswamy K; Yang J; DeMayo FJ; Whitsett JA; Parmacek MS; Morrisey EE
Nat Genet; 2008 Jul; 40(7):862-70. PubMed ID: 18536717
[TBL] [Abstract][Full Text] [Related]
19. A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer.
Kloesch B; Ionasz V; Paliwal S; Hruschka N; Martinez de Villarreal J; Öllinger R; Mueller S; Dienes HP; Schindl M; Gruber ES; Stift J; Herndler-Brandstetter D; Lomberk GA; Seidler B; Saur D; Rad R; Urrutia RA; Real FX; Martinelli P
Gut; 2022 Apr; 71(4):766-777. PubMed ID: 33846140
[TBL] [Abstract][Full Text] [Related]
20. Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer.
Kwei KA; Bashyam MD; Kao J; Ratheesh R; Reddy EC; Kim YH; Montgomery K; Giacomini CP; Choi YL; Chatterjee S; Karikari CA; Salari K; Wang P; Hernandez-Boussard T; Swarnalata G; van de Rijn M; Maitra A; Pollack JR
PLoS Genet; 2008 May; 4(5):e1000081. PubMed ID: 18535672
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
