BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

220 related articles for article (PubMed ID: 35548854)

  • 1. New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization.
    Mohammed HHH; Abd El-Hafeez AA; Ebeid K; Mekkawy AI; Abourehab MAS; Wafa EI; Alhaj-Suliman SO; Salem AK; Ghosh P; Abuo-Rahma GEA; Hayallah AM; Abbas SH
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):1346-1363. PubMed ID: 35548854
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel urea linked ciprofloxacin-chalcone hybrids having antiproliferative topoisomerases I/II inhibitory activities and caspases-mediated apoptosis.
    Mohammed HHH; Abbas SH; Hayallah AM; Abuo-Rahma GEA; Mostafa YA
    Bioorg Chem; 2021 Jan; 106():104422. PubMed ID: 33248713
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity.
    Kassab AE; Gedawy EM
    Eur J Med Chem; 2018 Apr; 150():403-418. PubMed ID: 29547830
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities.
    Ahmed AHH; Mohamed MFA; Allam RM; Nafady A; Mohamed SK; Gouda AE; Beshr EAM
    Bioorg Chem; 2022 Dec; 129():106171. PubMed ID: 36166898
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity.
    Abdel-Aziz M; Park SE; Abuo-Rahma Gel-D; Sayed MA; Kwon Y
    Eur J Med Chem; 2013 Nov; 69():427-38. PubMed ID: 24090914
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors.
    El-Adl K; El-Helby AA; Sakr H; Elwan A
    Bioorg Chem; 2020 Dec; 105():104399. PubMed ID: 33113414
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, Anticancer Activity and Molecular Modeling Studies of Novel Chalcone Derivatives Containing Indole and Naphthalene Moieties as Tubulin Polymerization Inhibitors.
    Wang G; Peng Z; Li Y
    Chem Pharm Bull (Tokyo); 2019 Jul; 67(7):725-728. PubMed ID: 30982797
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of different heterocycles-linked chalcone conjugates as cytotoxic agents and tubulin polymerization inhibitors.
    Shankaraiah N; Nekkanti S; Brahma UR; Praveen Kumar N; Deshpande N; Prasanna D; Senwar KR; Jaya Lakshmi U
    Bioorg Med Chem; 2017 Sep; 25(17):4805-4816. PubMed ID: 28774575
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and Preclinical Evaluation of Indole Triazole Conjugates as Microtubule Targeting Agents that are Effective against MCF-7 Breast Cancer Cell Lines.
    Yele V; Pindiprolu SKSS; Sana S; Ramamurty DSVNM; Madasi JRK; Vadlamani S
    Anticancer Agents Med Chem; 2021; 21(8):1047-1055. PubMed ID: 32981511
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, biological evaluation and molecular docking studies of a new series of chalcones containing naphthalene moiety as anticancer agents.
    Wang G; Qiu J; Xiao X; Cao A; Zhou F
    Bioorg Chem; 2018 Feb; 76():249-257. PubMed ID: 29197743
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1,2,3-triazole-4-yl derivatives as topoisomerase II inhibitors.
    Abdel-Hafez GA; Mohamed AI; Youssef AF; Simons C; Aboraia AS
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):502-513. PubMed ID: 35012398
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 3,7-bis-benzylidene hydrazide ciprofloxacin derivatives as promising antiproliferative dual TOP I & TOP II isomerases inhibitors.
    Samir M; Ramadan M; Abdelrahman MH; Abdelbaset MS; Abourehab MAS; Abdel-Aziz M; Abuo-Rahma GEA
    Bioorg Chem; 2021 May; 110():104698. PubMed ID: 33676043
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme.
    Swedan HK; Kassab AE; Gedawy EM; Elmeligie SE
    J Enzyme Inhib Med Chem; 2023 Dec; 38(1):118-137. PubMed ID: 36305290
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site.
    Wang G; Liu W; Gong Z; Huang Y; Li Y; Peng Z
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):139-144. PubMed ID: 31724435
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors.
    Eissa IH; Metwaly AM; Belal A; Mehany ABM; Ayyad RR; El-Adl K; Mahdy HA; Taghour MS; El-Gamal KMA; El-Sawah ME; Elmetwally SA; Elhendawy MA; Radwan MM; ElSohly MA
    Arch Pharm (Weinheim); 2019 Nov; 352(11):e1900123. PubMed ID: 31463953
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization.
    Kamal A; Reddy NV; Nayak VL; Bolla NR; Subba Rao AV; Prasad B
    Bioorg Med Chem; 2014 Jul; 22(13):3465-77. PubMed ID: 24835786
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of novel rigid analogs of 2-naphthol with potent anticancer activity through multi-target topoisomerase I & II and tyrosine kinase receptor EGFR & VEGFR-2 inhibition mechanism.
    El-Mawgoud HKA; Fouda AM; El-Nassag MAA; Elhenawy AA; Alshahrani MY; El-Agrody AM
    Chem Biol Interact; 2022 Mar; 355():109838. PubMed ID: 35123995
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and modelling study of new 1,2,3-triazole/chalcone hybrids with antiproliferative action as epidermal growth factor receptor inhibitors.
    Maghraby MT; Salem OIA; Youssif BGM; Sheha MM
    Chem Biol Drug Des; 2023 Mar; 101(3):749-759. PubMed ID: 36366966
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects.
    Alswah M; Bayoumi AH; Elgamal K; Elmorsy A; Ihmaid S; Ahmed HEA
    Molecules; 2017 Dec; 23(1):. PubMed ID: 29280968
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition.
    Amin MM; Abuo-Rahma GEA; Shaykoon MSA; Marzouk AA; Abourehab MAS; Saraya RE; Badr M; Sayed AM; Beshr EAM
    Bioorg Chem; 2023 May; 134():106444. PubMed ID: 36893547
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.