These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 35580424)

  • 1. Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities.
    Zhang Y; Yang H; Wang FT; Peng X; Liu HY; Li QJ; An LK
    Eur J Med Chem; 2022 Aug; 238():114445. PubMed ID: 35580424
    [TBL] [Abstract][Full Text] [Related]  

  • 2. TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
    Zeng Z; Sharma A; Ju L; Murai J; Umans L; Vermeire L; Pommier Y; Takeda S; Huylebroeck D; Caldecott KW; El-Khamisy SF
    Nucleic Acids Res; 2012 Sep; 40(17):8371-80. PubMed ID: 22740648
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.
    Kont YS; Dutta A; Mallisetty A; Mathew J; Minas T; Kraus C; Dhopeshwarkar P; Kallakury B; Mitra S; Üren A; Adhikari S
    DNA Repair (Amst); 2016 Jul; 43():38-47. PubMed ID: 27235629
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding.
    Shimizu N; Hamada Y; Morozumi R; Yamamoto J; Iwai S; Sugiyama KI; Ide H; Tsuda M
    J Biol Chem; 2023 Aug; 299(8):104988. PubMed ID: 37392847
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.
    Kiselev E; Ravji A; Kankanala J; Xie J; Wang Z; Pommier Y
    DNA Repair (Amst); 2020 Jan; 85():102747. PubMed ID: 31775111
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).
    Kankanala J; Marchand C; Abdelmalak M; Aihara H; Pommier Y; Wang Z
    J Med Chem; 2016 Mar; 59(6):2734-46. PubMed ID: 26910725
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide.
    Kankanala J; Ribeiro CJA; Kiselev E; Ravji A; Williams J; Xie J; Aihara H; Pommier Y; Wang Z
    J Med Chem; 2019 May; 62(9):4669-4682. PubMed ID: 30998359
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms.
    Tsuda M; Kitamasu K; Hosokawa S; Nakano T; Ide H
    Nucleosides Nucleotides Nucleic Acids; 2020; 39(1-3):170-184. PubMed ID: 31608820
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3'-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1).
    Tsuda M; Kitamasu K; Kumagai C; Sugiyama K; Nakano T; Ide H
    DNA Repair (Amst); 2020; 91-92():102849. PubMed ID: 32460231
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Robustadial A and B from Eucalyptus globulus Labill. and their anticancer activity as selective tyrosyl-DNA phosphodiesterase 2 inhibitors.
    Zhang Y; He XZ; Yang H; Liu HY; An LK
    Phytother Res; 2021 Sep; 35(9):5282-5289. PubMed ID: 34314073
    [TBL] [Abstract][Full Text] [Related]  

  • 11. TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
    Zeng Z; Cortés-Ledesma F; El Khamisy SF; Caldecott KW
    J Biol Chem; 2011 Jan; 286(1):403-9. PubMed ID: 21030584
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).
    Gao R; Schellenberg MJ; Huang SY; Abdelmalak M; Marchand C; Nitiss KC; Nitiss JL; Williams RS; Pommier Y
    J Biol Chem; 2014 Jun; 289(26):17960-9. PubMed ID: 24808172
    [TBL] [Abstract][Full Text] [Related]  

  • 13. TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
    Gómez-Herreros F; Romero-Granados R; Zeng Z; Alvarez-Quilón A; Quintero C; Ju L; Umans L; Vermeire L; Huylebroeck D; Caldecott KW; Cortés-Ledesma F
    PLoS Genet; 2013; 9(3):e1003226. PubMed ID: 23505375
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents.
    Zakharenko AL; Dyrkheeva NS; Luzina OA; Filimonov AS; Mozhaitsev ES; Malakhova AA; Medvedev SP; Zakian SM; Salakhutdinov NF; Lavrik OI
    Genes (Basel); 2023 Oct; 14(10):. PubMed ID: 37895279
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex.
    Bhattacharjee S; Rehman I; Nandy S; Das BB
    DNA Repair (Amst); 2022 Mar; 111():103277. PubMed ID: 35101776
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential.
    Laev SS; Salakhutdinov NF; Lavrik OI
    Bioorg Med Chem; 2016 Nov; 24(21):5017-5027. PubMed ID: 27687971
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.
    Nitiss KC; Malik M; He X; White SW; Nitiss JL
    Proc Natl Acad Sci U S A; 2006 Jun; 103(24):8953-8. PubMed ID: 16751265
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and Biological Activities of 11- and 12-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.
    Yang H; Qin C; Wu M; Wang FT; Wang W; Agama K; Pommier Y; Hu DX; An LK
    ChemMedChem; 2023 May; 18(10):e202200593. PubMed ID: 36932053
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes.
    Lee KC; Swan RL; Sondka Z; Padget K; Cowell IG; Austin CA
    Int J Mol Sci; 2018 Jul; 19(7):. PubMed ID: 30011940
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux.
    Komulainen E; Pennicott L; Le Grand D; Caldecott KW
    ACS Chem Biol; 2019 Jun; 14(6):1110-1114. PubMed ID: 31091068
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.