BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

250 related articles for article (PubMed ID: 35580815)

  • 1. Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.
    Kluss JH; Bonet-Ponce L; Lewis PA; Cookson MR
    Neurobiol Dis; 2022 Aug; 170():105769. PubMed ID: 35580815
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Lysosomal positioning regulates Rab10 phosphorylation at LRRK2
    Kluss JH; Beilina A; Williamson CD; Lewis PA; Cookson MR; Bonet-Ponce L
    Proc Natl Acad Sci U S A; 2022 Oct; 119(43):e2205492119. PubMed ID: 36256825
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
    Wang X; Bondar VV; Davis OB; Maloney MT; Agam M; Chin MY; Cheuk-Nga Ho A; Ghosh R; Leto DE; Joy D; Calvert MEK; Lewcock JW; Di Paolo G; Thorne RG; Sweeney ZK; Henry AG
    Elife; 2023 Oct; 12():. PubMed ID: 37874617
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
    Kalogeropulou AF; Freemantle JB; Lis P; Vides EG; Polinski NK; Alessi DR
    Biochem J; 2020 Nov; 477(22):4397-4423. PubMed ID: 33135724
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations.
    Rivero-Ríos P; Romo-Lozano M; Fernández B; Fdez E; Hilfiker S
    Cells; 2020 Jul; 9(7):. PubMed ID: 32709066
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.
    Rivero-Ríos P; Romo-Lozano M; Madero-Pérez J; Thomas AP; Biosa A; Greggio E; Hilfiker S
    J Biol Chem; 2019 Mar; 294(13):4738-4758. PubMed ID: 30709905
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes.
    Unapanta A; Shavarebi F; Porath J; Shen Y; Balen C; Nguyen A; Tseng J; Leong WS; Liu M; Lis P; Di Pietro SM; Hiniker A
    J Biol Chem; 2023 Oct; 299(10):105192. PubMed ID: 37625589
    [TBL] [Abstract][Full Text] [Related]  

  • 8. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
    Eguchi T; Kuwahara T; Sakurai M; Komori T; Fujimoto T; Ito G; Yoshimura SI; Harada A; Fukuda M; Koike M; Iwatsubo T
    Proc Natl Acad Sci U S A; 2018 Sep; 115(39):E9115-E9124. PubMed ID: 30209220
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.
    Dhekne HS; Tonelli F; Yeshaw WM; Chiang CY; Limouse C; Jaimon E; Purlyte E; Alessi DR; Pfeffer SR
    Elife; 2023 Oct; 12():. PubMed ID: 37874635
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Development of phospho-specific Rab protein antibodies to monitor
    Lis P; Burel S; Steger M; Mann M; Brown F; Diez F; Tonelli F; Holton JL; Ho PW; Ho SL; Chou MY; Polinski NK; Martinez TN; Davies P; Alessi DR
    Biochem J; 2018 Jan; 475(1):1-22. PubMed ID: 29127256
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation.
    Vides EG; Adhikari A; Chiang CY; Lis P; Purlyte E; Limouse C; Shumate JL; Spínola-Lasso E; Dhekne HS; Alessi DR; Pfeffer SR
    Elife; 2022 Sep; 11():. PubMed ID: 36149401
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pathogenic LRRK2 compromises the subcellular distribution of lysosomes in a Rab12-RILPL1-dependent manner.
    Ito K; Araki M; Katai Y; Nishimura Y; Imotani S; Inoue H; Ito G; Tomita T
    FASEB J; 2023 May; 37(5):e22930. PubMed ID: 37086089
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2.
    Komori T; Kuwahara T; Fujimoto T; Sakurai M; Koyama-Honda I; Fukuda M; Iwatsubo T
    J Cell Sci; 2023 Jul; 136(14):. PubMed ID: 37365944
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation.
    Kuwahara T; Funakawa K; Komori T; Sakurai M; Yoshii G; Eguchi T; Fukuda M; Iwatsubo T
    Neurobiol Dis; 2020 Nov; 145():105081. PubMed ID: 32919031
    [TBL] [Abstract][Full Text] [Related]  

  • 15. LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
    Liu Z; Bryant N; Kumaran R; Beilina A; Abeliovich A; Cookson MR; West AB
    Hum Mol Genet; 2018 Jan; 27(2):385-395. PubMed ID: 29177506
    [TBL] [Abstract][Full Text] [Related]  

  • 16. LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
    Liu Z; Xu E; Zhao HT; Cole T; West AB
    EMBO J; 2020 Oct; 39(20):e104862. PubMed ID: 32853409
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.
    Kluss JH; Mazza MC; Li Y; Manzoni C; Lewis PA; Cookson MR; Mamais A
    Mol Neurodegener; 2021 Mar; 16(1):17. PubMed ID: 33741046
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
    Mir R; Tonelli F; Lis P; Macartney T; Polinski NK; Martinez TN; Chou MY; Howden AJM; König T; Hotzy C; Milenkovic I; Brücke T; Zimprich A; Sammler E; Alessi DR
    Biochem J; 2018 Jun; 475(11):1861-1883. PubMed ID: 29743203
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases.
    Gomez RC; Wawro P; Lis P; Alessi DR; Pfeffer SR
    J Cell Biol; 2019 Dec; 218(12):4157-4170. PubMed ID: 31624137
    [TBL] [Abstract][Full Text] [Related]  

  • 20. LRRK2 mediates tubulation and vesicle sorting from lysosomes.
    Bonet-Ponce L; Beilina A; Williamson CD; Lindberg E; Kluss JH; Saez-Atienzar S; Landeck N; Kumaran R; Mamais A; Bleck CKE; Li Y; Cookson MR
    Sci Adv; 2020 Nov; 6(46):. PubMed ID: 33177079
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.