BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 35605413)

  • 1. Cyclin-dependent kinase 8 is an independent prognosticator in uterine leiomyosarcoma.
    Yasutake N; Iwasaki T; Yamamoto H; Sonoda K; Kodama K; Okugawa K; Asanoma K; Yahata H; Kato K; Oda Y
    Pathol Res Pract; 2022 Jul; 235():153920. PubMed ID: 35605413
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
    Park MJ; Shen H; Spaeth JM; Tolvanen JH; Failor C; Knudtson JF; McLaughlin J; Halder SK; Yang Q; Bulun SE; Al-Hendy A; Schenken RS; Aaltonen LA; Boyer TG
    J Biol Chem; 2018 Mar; 293(13):4870-4882. PubMed ID: 29440396
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.
    Turunen M; Spaeth JM; Keskitalo S; Park MJ; Kivioja T; Clark AD; Mäkinen N; Gao F; Palin K; Nurkkala H; Vähärautio A; Aavikko M; Kämpjärvi K; Vahteristo P; Kim CA; Aaltonen LA; Varjosalo M; Taipale J; Boyer TG
    Cell Rep; 2014 May; 7(3):654-60. PubMed ID: 24746821
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mediator Kinase Disruption in MED12-Mutant Uterine Fibroids From Hispanic Women of South Texas.
    Park MJ; Shen H; Kim NH; Gao F; Failor C; Knudtson JF; McLaughlin J; Halder SK; Heikkinen TA; Vahteristo P; Al-Hendy A; Schenken RS; Boyer TG
    J Clin Endocrinol Metab; 2018 Nov; 103(11):4283-4292. PubMed ID: 30099503
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.
    Klatt F; Leitner A; Kim IV; Ho-Xuan H; Schneider EV; Langhammer F; Weinmann R; Müller MR; Huber R; Meister G; Kuhn CD
    Proc Natl Acad Sci U S A; 2020 Feb; 117(6):2894-2905. PubMed ID: 31988137
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CDK8 Expression in Extrauterine Leiomyosarcoma Correlates With Tumor Stage and Progression.
    Yergiyev O; Garib G; Schoedel K; Palekar A; Bartlett D; Rao UNM
    Appl Immunohistochem Mol Morphol; 2018 Mar; 26(3):161-164. PubMed ID: 27389556
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas.
    Mäkinen N; Heinonen HR; Sjöberg J; Taipale J; Vahteristo P; Aaltonen LA
    Br J Cancer; 2014 Apr; 110(9):2246-9. PubMed ID: 24642626
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.
    Belakavadi M; Fondell JD
    Mol Cell Biol; 2010 May; 30(10):2437-48. PubMed ID: 20231357
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
    Kämpjärvi K; Kim NH; Keskitalo S; Clark AD; von Nandelstadh P; Turunen M; Heikkinen T; Park MJ; Mäkinen N; Kivinummi K; Lintula S; Hotakainen K; Nevanlinna H; Hokland P; Böhling T; Bützow R; Böhm J; Mecklin JP; Järvinen H; Kontro M; Visakorpi T; Taipale J; Varjosalo M; Boyer TG; Vahteristo P
    Prostate; 2016 Jan; 76(1):22-31. PubMed ID: 26383637
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.
    Sooraj D; Sun C; Doan A; Garama DJ; Dannappel MV; Zhu D; Chua HK; Mahara S; Wan Hassan WA; Tay YK; Guanizo A; Croagh D; Prodanovic Z; Gough DJ; Wan C; Firestein R
    Mol Cell; 2022 Jan; 82(1):123-139.e7. PubMed ID: 34910943
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.
    Kämpjärvi K; Park MJ; Mehine M; Kim NH; Clark AD; Bützow R; Böhling T; Böhm J; Mecklin JP; Järvinen H; Tomlinson IP; van der Spuy ZM; Sjöberg J; Boyer TG; Vahteristo P
    Hum Mutat; 2014 Sep; 35(9):1136-41. PubMed ID: 24980722
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.
    Kämpjärvi K; Mäkinen N; Kilpivaara O; Arola J; Heinonen HR; Böhm J; Abdel-Wahab O; Lehtonen HJ; Pelttari LM; Mehine M; Schrewe H; Nevanlinna H; Levine RL; Hokland P; Böhling T; Mecklin JP; Bützow R; Aaltonen LA; Vahteristo P
    Br J Cancer; 2012 Nov; 107(10):1761-5. PubMed ID: 23132392
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification and characterization of the mediator kinase-dependent myometrial stem cell phosphoproteome.
    Barron L; Khadka S; Schenken R; He L; Blenis J; Blagg J; Chen SF; Tsai KL; Boyer TG
    F S Sci; 2021 Nov; 2(4):383-395. PubMed ID: 35559861
    [TBL] [Abstract][Full Text] [Related]  

  • 14. MED12 and uterine smooth muscle oncogenesis: State of the art and perspectives.
    Croce S; Chibon F
    Eur J Cancer; 2015 Aug; 51(12):1603-10. PubMed ID: 26037152
    [TBL] [Abstract][Full Text] [Related]  

  • 15. MED12 somatic mutations encompassing exon 2 associated with benign breast fibroadenomas and not breast carcinoma in Indian women.
    Darooei M; Khan F; Rehan M; Zubeda S; Jeyashanker E; Annapurna S; Shah A; Maddali S; Hasan Q
    J Cell Biochem; 2019 Jan; 120(1):182-191. PubMed ID: 30230586
    [TBL] [Abstract][Full Text] [Related]  

  • 16. MED12 interacts with the heat-shock transcription factor HSF1 and recruits CDK8 to promote the heat-shock response in mammalian cells.
    Srivastava P; Takii R; Okada M; Fujimoto M; Nakai A
    FEBS Lett; 2021 Jul; 595(14):1933-1948. PubMed ID: 34056708
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.
    Gobert V; Osman D; Bras S; Augé B; Boube M; Bourbon HM; Horn T; Boutros M; Haenlin M; Waltzer L
    Mol Cell Biol; 2010 Jun; 30(11):2837-48. PubMed ID: 20368357
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Highly heterogeneous genomic landscape of uterine leiomyomas by whole exome sequencing and genome-wide arrays.
    Yatsenko SA; Mittal P; Wood-Trageser MA; Jones MW; Surti U; Edwards RP; Sood AK; Rajkovic A
    Fertil Steril; 2017 Feb; 107(2):457-466.e9. PubMed ID: 27889101
    [TBL] [Abstract][Full Text] [Related]  

  • 19. CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival.
    Firestein R; Shima K; Nosho K; Irahara N; Baba Y; Bojarski E; Giovannucci EL; Hahn WC; Fuchs CS; Ogino S
    Int J Cancer; 2010 Jun; 126(12):2863-73. PubMed ID: 19790197
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.
    Kuuluvainen E; Hakala H; Havula E; Sahal Estimé M; Rämet M; Hietakangas V; Mäkelä TP
    J Biol Chem; 2014 Jun; 289(23):16252-61. PubMed ID: 24778181
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.