BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

249 related articles for article (PubMed ID: 35680956)

  • 1. Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy.
    Fanning S; Cirka H; Thies JL; Jeong J; Niemi SM; Yoon J; Ho GPH; Pacheco JA; Dettmer U; Liu L; Clish CB; Hodgetts KJ; Hutchinson JN; Muratore CR; Caldwell GA; Caldwell KA; Selkoe D
    NPJ Parkinsons Dis; 2022 Jun; 8(1):74. PubMed ID: 35680956
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
    Fanning S; Haque A; Imberdis T; Baru V; Barrasa MI; Nuber S; Termine D; Ramalingam N; Ho GPH; Noble T; Sandoe J; Lou Y; Landgraf D; Freyzon Y; Newby G; Soldner F; Terry-Kantor E; Kim TE; Hofbauer HF; Becuwe M; Jaenisch R; Pincus D; Clish CB; Walther TC; Farese RV; Srinivasan S; Welte MA; Kohlwein SD; Dettmer U; Lindquist S; Selkoe D
    Mol Cell; 2019 Mar; 73(5):1001-1014.e8. PubMed ID: 30527540
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
    Imberdis T; Negri J; Ramalingam N; Terry-Kantor E; Ho GPH; Fanning S; Stirtz G; Kim TE; Levy OA; Young-Pearse TL; Selkoe D; Dettmer U
    Proc Natl Acad Sci U S A; 2019 Oct; 116(41):20760-20769. PubMed ID: 31548371
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.
    Tripathi A; Alnakhala H; Terry-Kantor E; Newman A; Liu L; Imberdis T; Fanning S; Nuber S; Ramalingam N; Selkoe D; Dettmer U
    J Neurosci; 2022 Mar; 42(10):2116-2130. PubMed ID: 35086904
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MUFA synthesis and stearoyl-CoA desaturase as a new pharmacological target for modulation of lipid and alpha-synuclein interaction against Parkinson's disease synucleinopathy.
    Kula J; Kuter KZ
    Neuropharmacology; 2024 May; 249():109865. PubMed ID: 38342377
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes.
    Nuber S; Zhang X; McCaffery TD; Moors TE; Adom MA; Hahn WN; Martin D; Ericsson M; Tripathi A; Dettmer U; Svenningsson P; Selkoe DJ
    NPJ Parkinsons Dis; 2024 Feb; 10(1):47. PubMed ID: 38424059
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
    Glajch KE; Moors TE; Chen Y; Bechade PA; Nam AY; Rajsombath MM; McCaffery TD; Dettmer U; Weihofen A; Hirst WD; Selkoe DJ; Nuber S
    Proc Natl Acad Sci U S A; 2021 Aug; 118(31):. PubMed ID: 34326260
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.
    Terry-Kantor E; Tripathi A; Imberdis T; LaVoie ZM; Ho GPH; Selkoe D; Fanning S; Ramalingam N; Dettmer U
    Int J Mol Sci; 2020 Jul; 21(15):. PubMed ID: 32707907
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
    Nuber S; Nam AY; Rajsombath MM; Cirka H; Hronowski X; Wang J; Hodgetts K; Kalinichenko LS; Müller CP; Lambrecht V; Winkler J; Weihofen A; Imberdis T; Dettmer U; Fanning S; Selkoe DJ
    Ann Neurol; 2021 Jan; 89(1):74-90. PubMed ID: 32996158
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.
    Nuber S; Rajsombath M; Minakaki G; Winkler J; Müller CP; Ericsson M; Caldarone B; Dettmer U; Selkoe DJ
    Neuron; 2018 Oct; 100(1):75-90.e5. PubMed ID: 30308173
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Parkinson's disease: proteinopathy or lipidopathy?
    Fanning S; Selkoe D; Dettmer U
    NPJ Parkinsons Dis; 2020; 6():3. PubMed ID: 31909184
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice.
    Rajsombath MM; Nam AY; Ericsson M; Nuber S
    J Neurosci; 2019 Sep; 39(38):7628-7640. PubMed ID: 31405930
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity.
    Nuber S; Chung CY; Tardiff DF; Bechade PA; McCaffery TD; Shimanaka K; Choi J; Chang B; Raja W; Neves E; Burke C; Jiang X; Xu P; Khurana V; Dettmer U; Fanning S; Rhodes KJ; Selkoe DJ; Scannevin RH
    Neurotherapeutics; 2022 Apr; 19(3):1018-1036. PubMed ID: 35445353
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons.
    Fonseca-Ornelas L; Stricker JMS; Soriano-Cruz S; Weykopf B; Dettmer U; Muratore CR; Scherzer CR; Selkoe DJ
    NPJ Parkinsons Dis; 2022 Sep; 8(1):118. PubMed ID: 36114228
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies.
    Sharon R; Bar-Joseph I; Mirick GE; Serhan CN; Selkoe DJ
    J Biol Chem; 2003 Dec; 278(50):49874-81. PubMed ID: 14507911
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.
    Dettmer U; Newman AJ; Soldner F; Luth ES; Kim NC; von Saucken VE; Sanderson JB; Jaenisch R; Bartels T; Selkoe D
    Nat Commun; 2015 Jun; 6():7314. PubMed ID: 26076669
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity.
    Ho GPH; Ramalingam N; Imberdis T; Wilkie EC; Dettmer U; Selkoe DJ
    Mov Disord; 2021 Feb; 36(2):348-359. PubMed ID: 33103814
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
    Dettmer U; Ramalingam N; von Saucken VE; Kim TE; Newman AJ; Terry-Kantor E; Nuber S; Ericsson M; Fanning S; Bartels T; Lindquist S; Levy OA; Selkoe D
    Hum Mol Genet; 2017 Sep; 26(18):3466-3481. PubMed ID: 28911198
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Vesicle trafficking and lipid metabolism in synucleinopathy.
    Fanning S; Selkoe D; Dettmer U
    Acta Neuropathol; 2021 Apr; 141(4):491-510. PubMed ID: 32607605
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells.
    Assayag K; Yakunin E; Loeb V; Selkoe DJ; Sharon R
    Am J Pathol; 2007 Dec; 171(6):2000-11. PubMed ID: 18055555
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.