These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 35691342)

  • 1. A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.
    Webb CT; Yang W; Riley BT; Hayes BK; Sivaraman KK; Malcolm TR; Harrop S; Atkinson SC; Kass I; Buckle AM; Drinkwater N; McGowan S
    J Biol Chem; 2022 Jul; 298(7):102119. PubMed ID: 35691342
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
    Malcolm TR; Belousoff MJ; Venugopal H; Borg NA; Drinkwater N; Atkinson SC; McGowan S
    J Biol Chem; 2021; 296():100173. PubMed ID: 33303633
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
    McGowan S; Oellig CA; Birru WA; Caradoc-Davies TT; Stack CM; Lowther J; Skinner-Adams T; Mucha A; Kafarski P; Grembecka J; Trenholme KR; Buckle AM; Gardiner DL; Dalton JP; Whisstock JC
    Proc Natl Acad Sci U S A; 2010 Feb; 107(6):2449-54. PubMed ID: 20133789
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Genetic and chemical validation of
    Edgar RCS; Siddiqui G; Hjerrild K; Malcolm TR; Vinh NB; Webb CT; Holmes C; MacRaild CA; Chernih HC; Suen WW; Counihan NA; Creek DJ; Scammells PJ; McGowan S; de Koning-Ward TF
    Elife; 2022 Sep; 11():. PubMed ID: 36097817
    [TBL] [Abstract][Full Text] [Related]  

  • 5. M17 aminopeptidases diversify function by moderating their macromolecular assemblies and active site environment.
    Drinkwater N; Malcolm TR; McGowan S
    Biochimie; 2019 Nov; 166():38-51. PubMed ID: 30654132
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.
    Maric S; Donnelly SM; Robinson MW; Skinner-Adams T; Trenholme KR; Gardiner DL; Dalton JP; Stack CM; Lowther J
    Biochemistry; 2009 Jun; 48(23):5435-9. PubMed ID: 19408962
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
    Calic PPS; Vinh NB; Webb CT; Malcolm TR; Ngo A; Lowes K; Drinkwater N; McGowan S; Scammells PJ
    Eur J Med Chem; 2023 Feb; 248():115051. PubMed ID: 36634455
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases.
    Yang W; Riley BT; Lei X; Porebski BT; Kass I; Buckle AM; McGowan S
    J Biomol Struct Dyn; 2018 Aug; 36(10):2595-2604. PubMed ID: 28782419
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Modelling of human leucyl aminopeptidases for in silico off target binding analysis of potential Plasmodium falciparum leucine aminopeptidase (PfA-M17) specific inhibitors.
    Sahi S; Raj U; Chaudhary M; Nain V
    Recent Pat Endocr Metab Immune Drug Discov; 2014; 8(3):191-201. PubMed ID: 25269653
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium falciparum M1 Aminopeptidase PfA-M1.
    Yang W; Riley BT; Lei X; Porebski BT; Kass I; Buckle AM; McGowan S
    ChemMedChem; 2018 Dec; 13(23):2504-2513. PubMed ID: 30318749
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
    Drinkwater N; Vinh NB; Mistry SN; Bamert RS; Ruggeri C; Holleran JP; Loganathan S; Paiardini A; Charman SA; Powell AK; Avery VM; McGowan S; Scammells PJ
    Eur J Med Chem; 2016 Mar; 110():43-64. PubMed ID: 26807544
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Screening and In Vitro Evaluation of Potential Plasmodium falciparum Leucyl Aminopeptidase Inhibitors.
    Chaudhary M; Singh V; Anvikar AR; Sahi S
    Curr Comput Aided Drug Des; 2016; 12(4):282-293. PubMed ID: 27449897
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.
    Paiardini A; Bamert RS; Kannan-Sivaraman K; Drinkwater N; Mistry SN; Scammells PJ; McGowan S
    PLoS One; 2015; 10(2):e0115859. PubMed ID: 25700165
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
    Ruggeri C; Drinkwater N; Sivaraman KK; Bamert RS; McGowan S; Paiardini A
    PLoS One; 2015; 10(9):e0138957. PubMed ID: 26406322
    [TBL] [Abstract][Full Text] [Related]  

  • 15. X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.
    Drinkwater N; Bamert RS; Sivaraman KK; Paiardini A; McGowan S
    Proteins; 2015 Apr; 83(4):789-95. PubMed ID: 25645579
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases.
    Malcolm TR; Swiderska KW; Hayes BK; Webb CT; Drag M; Drinkwater N; McGowan S
    Biochem J; 2021 Jul; 478(13):2697-2713. PubMed ID: 34133730
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.
    Bounaadja L; Schmitt M; Albrecht S; Mouray E; Tarnus C; Florent I
    Malar J; 2017 Sep; 16(1):382. PubMed ID: 28934959
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Parasite Metalo-aminopeptidases as Targets in Human Infectious Diseases.
    Aguado ME; Izquierdo M; González-Matos M; Varela AC; Méndez Y; Del Rivero MA; Rivera DG; González-Bacerio J
    Curr Drug Targets; 2023; 24(5):416-461. PubMed ID: 36825701
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum.
    Kannan Sivaraman K; Paiardini A; Sieńczyk M; Ruggeri C; Oellig CA; Dalton JP; Scammells PJ; Drag M; McGowan S
    J Med Chem; 2013 Jun; 56(12):5213-7. PubMed ID: 23713488
    [TBL] [Abstract][Full Text] [Related]  

  • 20. X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.
    Sivaraman KK; Oellig CA; Huynh K; Atkinson SC; Poreba M; Perugini MA; Trenholme KR; Gardiner DL; Salvesen G; Drag M; Dalton JP; Whisstock JC; McGowan S
    J Mol Biol; 2012 Sep; 422(4):495-507. PubMed ID: 22709581
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.