178 related articles for article (PubMed ID: 35717507)
1. The role of cholesterol binding in the control of cholesterol by the Scap-Insig system.
Lee AG
Eur Biophys J; 2022 Jul; 51(4-5):385-399. PubMed ID: 35717507
[TBL] [Abstract][Full Text] [Related]
2. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
Yang T; Espenshade PJ; Wright ME; Yabe D; Gong Y; Aebersold R; Goldstein JL; Brown MS
Cell; 2002 Aug; 110(4):489-500. PubMed ID: 12202038
[TBL] [Abstract][Full Text] [Related]
3. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
Gong Y; Lee JN; Lee PC; Goldstein JL; Brown MS; Ye J
Cell Metab; 2006 Jan; 3(1):15-24. PubMed ID: 16399501
[TBL] [Abstract][Full Text] [Related]
4. Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.
Kober DL; Radhakrishnan A; Goldstein JL; Brown MS; Clark LD; Bai XC; Rosenbaum DM
Cell; 2021 Jul; 184(14):3689-3701.e22. PubMed ID: 34139175
[TBL] [Abstract][Full Text] [Related]
5. Structural basis for sterol sensing by Scap and Insig.
Yan R; Cao P; Song W; Li Y; Wang T; Qian H; Yan C; Yan N
Cell Rep; 2021 Jun; 35(13):109299. PubMed ID: 34192549
[TBL] [Abstract][Full Text] [Related]
6. Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi.
Zhang Y; Motamed M; Seemann J; Brown MS; Goldstein JL
J Biol Chem; 2013 May; 288(20):14059-14067. PubMed ID: 23564452
[TBL] [Abstract][Full Text] [Related]
7. Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis.
Motamed M; Zhang Y; Wang ML; Seemann J; Kwon HJ; Goldstein JL; Brown MS
J Biol Chem; 2011 May; 286(20):18002-12. PubMed ID: 21454655
[TBL] [Abstract][Full Text] [Related]
8. Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.
Lee PC; DeBose-Boyd RA
J Lipid Res; 2010 Jan; 51(1):192-201. PubMed ID: 19617589
[TBL] [Abstract][Full Text] [Related]
9. Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.
Lee PC; Sever N; Debose-Boyd RA
J Biol Chem; 2005 Jul; 280(26):25242-9. PubMed ID: 15866869
[TBL] [Abstract][Full Text] [Related]
10. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.
Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N
Science; 2021 Mar; 371(6533):. PubMed ID: 33446483
[TBL] [Abstract][Full Text] [Related]
11. Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis.
Gao Y; Zhou Y; Goldstein JL; Brown MS; Radhakrishnan A
J Biol Chem; 2017 May; 292(21):8729-8737. PubMed ID: 28377508
[TBL] [Abstract][Full Text] [Related]
12. Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
Huber MD; Vesely PW; Datta K; Gerace L
J Cell Biol; 2013 Nov; 203(3):427-36. PubMed ID: 24217618
[TBL] [Abstract][Full Text] [Related]
13. Retrospective on Cholesterol Homeostasis: The Central Role of Scap.
Brown MS; Radhakrishnan A; Goldstein JL
Annu Rev Biochem; 2018 Jun; 87():783-807. PubMed ID: 28841344
[TBL] [Abstract][Full Text] [Related]
14. Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.
Gong Y; Lee JN; Brown MS; Goldstein JL; Ye J
Proc Natl Acad Sci U S A; 2006 Apr; 103(16):6154-9. PubMed ID: 16606821
[TBL] [Abstract][Full Text] [Related]
15. Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles.
Adams CM; Goldstein JL; Brown MS
Proc Natl Acad Sci U S A; 2003 Sep; 100(19):10647-52. PubMed ID: 12963821
[TBL] [Abstract][Full Text] [Related]
16. Membrane topology of human insig-1, a protein regulator of lipid synthesis.
Feramisco JD; Goldstein JL; Brown MS
J Biol Chem; 2004 Feb; 279(9):8487-96. PubMed ID: 14660594
[TBL] [Abstract][Full Text] [Related]
17. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins.
Sun LP; Seemann J; Goldstein JL; Brown MS
Proc Natl Acad Sci U S A; 2007 Apr; 104(16):6519-26. PubMed ID: 17428919
[TBL] [Abstract][Full Text] [Related]
18. Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP.
Kuan YC; Takahashi Y; Maruyama T; Shimizu M; Yamauchi Y; Sato R
J Biol Chem; 2020 Mar; 295(12):3918-3928. PubMed ID: 32054686
[TBL] [Abstract][Full Text] [Related]
19. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
Xu D; Wang Z; Zhang Y; Jiang W; Pan Y; Song BL; Chen Y
Nat Commun; 2015 Aug; 6():8100. PubMed ID: 26311497
[TBL] [Abstract][Full Text] [Related]
20. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.
Dobrosotskaya IY; Goldstein JL; Brown MS; Rawson RB
J Biol Chem; 2003 Sep; 278(37):35837-43. PubMed ID: 12842885
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]