These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 35717507)

  • 21. Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells.
    Lee PC; Liu P; Li WP; Debose-Boyd RA
    J Lipid Res; 2007 Sep; 48(9):1944-54. PubMed ID: 17586788
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change.
    Feramisco JD; Radhakrishnan A; Ikeda Y; Reitz J; Brown MS; Goldstein JL
    Proc Natl Acad Sci U S A; 2005 Mar; 102(9):3242-7. PubMed ID: 15728349
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).
    Shao W; Espenshade PJ
    J Biol Chem; 2014 Mar; 289(11):7547-57. PubMed ID: 24478315
    [TBL] [Abstract][Full Text] [Related]  

  • 24. The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites.
    Wakana Y; Hayashi K; Nemoto T; Watanabe C; Taoka M; Angulo-Capel J; Garcia-Parajo MF; Kumata H; Umemura T; Inoue H; Arasaki K; Campelo F; Tagaya M
    J Cell Biol; 2021 Jan; 220(1):. PubMed ID: 33156328
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis.
    Kober DL; Xu S; Li S; Bajaj B; Liang G; Rosenbaum DM; Radhakrishnan A
    Proc Natl Acad Sci U S A; 2020 Nov; 117(45):28080-28091. PubMed ID: 33106423
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex.
    Yellaturu CR; Deng X; Park EA; Raghow R; Elam MB
    J Biol Chem; 2009 Nov; 284(46):31726-34. PubMed ID: 19759400
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.
    Radhakrishnan A; Ikeda Y; Kwon HJ; Brown MS; Goldstein JL
    Proc Natl Acad Sci U S A; 2007 Apr; 104(16):6511-8. PubMed ID: 17428920
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.
    Lee JN; Song B; DeBose-Boyd RA; Ye J
    J Biol Chem; 2006 Dec; 281(51):39308-15. PubMed ID: 17043353
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Sirolimus inhibits endogenous cholesterol synthesis induced by inflammatory stress in human vascular smooth muscle cells.
    Ma KL; Varghese Z; Ku Y; Powis SH; Chen Y; Moorhead JF; Ruan XZ
    Am J Physiol Heart Circ Physiol; 2010 Jun; 298(6):H1646-51. PubMed ID: 20348217
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum.
    Esquejo RM; Roqueta-Rivera M; Shao W; Phelan PE; Seneviratne U; Am Ende CW; Hershberger PM; Machamer CE; Espenshade PJ; Osborne TF
    Cell Chem Biol; 2021 Feb; 28(2):169-179.e7. PubMed ID: 33096051
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs.
    Adams CM; Reitz J; De Brabander JK; Feramisco JD; Li L; Brown MS; Goldstein JL
    J Biol Chem; 2004 Dec; 279(50):52772-80. PubMed ID: 15452130
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.
    Shao W; Machamer CE; Espenshade PJ
    J Lipid Res; 2016 Aug; 57(8):1564-73. PubMed ID: 27324795
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.
    Yang T; Goldstein JL; Brown MS
    J Biol Chem; 2000 Sep; 275(38):29881-6. PubMed ID: 10896675
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.
    Tsushima H; Tang YJ; Puviindran V; Hsu SC; Nadesan P; Yu C; Zhang H; Mirando AJ; Hilton MJ; Alman BA
    Development; 2018 Jul; 145(13):. PubMed ID: 29899135
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS.
    Zhang Y; Lee KM; Kinch LN; Clark L; Grishin NV; Rosenbaum DM; Brown MS; Goldstein JL; Radhakrishnan A
    J Biol Chem; 2016 Jun; 291(24):12888-12896. PubMed ID: 27068746
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.
    Yabe D; Xia ZP; Adams CM; Rawson RB
    Proc Natl Acad Sci U S A; 2002 Dec; 99(26):16672-7. PubMed ID: 12482938
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes.
    Ikeda Y; Demartino GN; Brown MS; Lee JN; Goldstein JL; Ye J
    J Biol Chem; 2009 Dec; 284(50):34889-900. PubMed ID: 19815544
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism.
    Brown AJ; Sun L; Feramisco JD; Brown MS; Goldstein JL
    Mol Cell; 2002 Aug; 10(2):237-45. PubMed ID: 12191470
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1.
    Lee JN; Ye J
    J Biol Chem; 2004 Oct; 279(43):45257-65. PubMed ID: 15304479
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro.
    Yuan Y; Zhao L; Chen Y; Moorhead JF; Varghese Z; Powis SH; Minogue S; Sun Z; Ruan XZ
    Am J Physiol Renal Physiol; 2011 Jul; 301(1):F236-43. PubMed ID: 21511699
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.