172 related articles for article (PubMed ID: 35721463)
1. Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.
Fdez E; Madero-Pérez J; Lara Ordóñez AJ; Naaldijk Y; Fasiczka R; Aiastui A; Ruiz-Martínez J; López de Munain A; Cowley SA; Wade-Martins R; Hilfiker S
iScience; 2022 Jun; 25(6):104476. PubMed ID: 35721463
[TBL] [Abstract][Full Text] [Related]
2. RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
Lara Ordónez AJ; Fernández B; Fdez E; Romo-Lozano M; Madero-Pérez J; Lobbestael E; Baekelandt V; Aiastui A; López de Munaín A; Melrose HL; Civiero L; Hilfiker S
Hum Mol Genet; 2019 Nov; 28(21):3552-3568. PubMed ID: 31428781
[TBL] [Abstract][Full Text] [Related]
3. The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.
Lara Ordóñez AJ; Fasiczka R; Fernández B; Naaldijk Y; Fdez E; Blanca Ramírez M; Phan S; Boassa D; Hilfiker S
Biol Open; 2022 Aug; 11(8):. PubMed ID: 35776681
[TBL] [Abstract][Full Text] [Related]
4. Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Madero-Pérez J; Fdez E; Fernández B; Lara Ordóñez AJ; Blanca Ramírez M; Gómez-Suaga P; Waschbüsch D; Lobbestael E; Baekelandt V; Nairn AC; Ruiz-Martínez J; Aiastui A; López de Munain A; Lis P; Comptdaer T; Taymans JM; Chartier-Harlin MC; Beilina A; Gonnelli A; Cookson MR; Greggio E; Hilfiker S
Mol Neurodegener; 2018 Jan; 13(1):3. PubMed ID: 29357897
[TBL] [Abstract][Full Text] [Related]
5. Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
Sobu Y; Wawro PS; Dhekne HS; Yeshaw WM; Pfeffer SR
Proc Natl Acad Sci U S A; 2021 Mar; 118(10):. PubMed ID: 33653948
[TBL] [Abstract][Full Text] [Related]
6. Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease.
Alexander KK; Naaldijk Y; Fasiczka R; Brahmia B; Chen T; Hilfiker S; Kennedy EJ
J Pept Sci; 2024 May; 30(5):e3563. PubMed ID: 38135900
[TBL] [Abstract][Full Text] [Related]
7. Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients.
Fernández B; Lara Ordóñez AJ; Fdez E; Mutez E; Comptdaer T; Leghay C; Kreisler A; Simonin C; Vandewynckel L; Defebvre L; Destée A; Bleuse S; Taymans JM; Chartier-Harlin MC; Hilfiker S
Biochem J; 2019 Oct; 476(19):2797-2813. PubMed ID: 31527116
[TBL] [Abstract][Full Text] [Related]
8. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
Steger M; Diez F; Dhekne HS; Lis P; Nirujogi RS; Karayel O; Tonelli F; Martinez TN; Lorentzen E; Pfeffer SR; Alessi DR; Mann M
Elife; 2017 Nov; 6():. PubMed ID: 29125462
[TBL] [Abstract][Full Text] [Related]
9. A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.
Dhekne HS; Yanatori I; Gomez RC; Tonelli F; Diez F; Schüle B; Steger M; Alessi DR; Pfeffer SR
Elife; 2018 Nov; 7():. PubMed ID: 30398148
[TBL] [Abstract][Full Text] [Related]
10. RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A.
Madero-Pérez J; Fernández B; Lara Ordóñez AJ; Fdez E; Lobbestael E; Baekelandt V; Hilfiker S
Front Mol Neurosci; 2018; 11():417. PubMed ID: 30483055
[TBL] [Abstract][Full Text] [Related]
11. Pathogenic LRRK2 compromises the subcellular distribution of lysosomes in a Rab12-RILPL1-dependent manner.
Ito K; Araki M; Katai Y; Nishimura Y; Imotani S; Inoue H; Ito G; Tomita T
FASEB J; 2023 May; 37(5):e22930. PubMed ID: 37086089
[TBL] [Abstract][Full Text] [Related]
12. Development of phospho-specific Rab protein antibodies to monitor
Lis P; Burel S; Steger M; Mann M; Brown F; Diez F; Tonelli F; Holton JL; Ho PW; Ho SL; Chou MY; Polinski NK; Martinez TN; Davies P; Alessi DR
Biochem J; 2018 Jan; 475(1):1-22. PubMed ID: 29127256
[TBL] [Abstract][Full Text] [Related]
13. LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.
Dhekne HS; Yanatori I; Vides EG; Sobu Y; Diez F; Tonelli F; Pfeffer SR
Life Sci Alliance; 2021 May; 4(5):. PubMed ID: 33727250
[TBL] [Abstract][Full Text] [Related]
14. Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.
Pal P; Taylor M; Lam PY; Tonelli F; Hecht CA; Lis P; Nirujogi RS; Phung TK; Yeshaw WM; Jaimon E; Fasimoye R; Dickie EA; Wightman M; Macartney T; Pfeffer SR; Alessi DR
Sci Adv; 2023 Dec; 9(50):eadj1205. PubMed ID: 38091401
[TBL] [Abstract][Full Text] [Related]
15. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Mir R; Tonelli F; Lis P; Macartney T; Polinski NK; Martinez TN; Chou MY; Howden AJM; König T; Hotzy C; Milenkovic I; Brücke T; Zimprich A; Sammler E; Alessi DR
Biochem J; 2018 Jun; 475(11):1861-1883. PubMed ID: 29743203
[TBL] [Abstract][Full Text] [Related]
16. Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation.
Kuwahara T; Funakawa K; Komori T; Sakurai M; Yoshii G; Eguchi T; Fukuda M; Iwatsubo T
Neurobiol Dis; 2020 Nov; 145():105081. PubMed ID: 32919031
[TBL] [Abstract][Full Text] [Related]
17. LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
Liu Z; Bryant N; Kumaran R; Beilina A; Abeliovich A; Cookson MR; West AB
Hum Mol Genet; 2018 Jan; 27(2):385-395. PubMed ID: 29177506
[TBL] [Abstract][Full Text] [Related]
18. Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations.
Rivero-Ríos P; Romo-Lozano M; Fernández B; Fdez E; Hilfiker S
Cells; 2020 Jul; 9(7):. PubMed ID: 32709066
[TBL] [Abstract][Full Text] [Related]
19. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.
Ito G; Katsemonova K; Tonelli F; Lis P; Baptista MA; Shpiro N; Duddy G; Wilson S; Ho PW; Ho SL; Reith AD; Alessi DR
Biochem J; 2016 Sep; 473(17):2671-85. PubMed ID: 27474410
[TBL] [Abstract][Full Text] [Related]
20. Leucine-Rich Repeat Kinases.
Alessi DR; Pfeffer SR
Annu Rev Biochem; 2024 Apr; ():. PubMed ID: 38621236
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
