BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

220 related articles for article (PubMed ID: 35768468)

  • 1. Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
    Willegems K; Eldstrom J; Kyriakis E; Ataei F; Sahakyan H; Dou Y; Russo S; Van Petegem F; Fedida D
    Nat Commun; 2022 Jun; 13(1):3760. PubMed ID: 35768468
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling.
    Hou P; Shi J; White KM; Gao Y; Cui J
    Elife; 2019 Jul; 8():. PubMed ID: 31329101
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.
    Yu H; Lin Z; Mattmann ME; Zou B; Terrenoire C; Zhang H; Wu M; McManus OB; Kass RS; Lindsley CW; Hopkins CR; Li M
    Proc Natl Acad Sci U S A; 2013 May; 110(21):8732-7. PubMed ID: 23650380
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.
    Mattmann ME; Yu H; Lin Z; Xu K; Huang X; Long S; Wu M; McManus OB; Engers DW; Le UM; Li M; Lindsley CW; Hopkins CR
    Bioorg Med Chem Lett; 2012 Sep; 22(18):5936-41. PubMed ID: 22910039
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.
    Sun J; MacKinnon R
    Cell; 2017 Jun; 169(6):1042-1050.e9. PubMed ID: 28575668
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers.
    Ma D; Zhong L; Yan Z; Yao J; Zhang Y; Ye F; Huang Y; Lai D; Yang W; Hou P; Guo J
    Proc Natl Acad Sci U S A; 2022 Nov; 119(45):e2207067119. PubMed ID: 36763058
    [TBL] [Abstract][Full Text] [Related]  

  • 7. ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state.
    Eldstrom J; McAfee DA; Dou Y; Wang Y; Fedida D
    J Gen Physiol; 2021 Dec; 153(12):. PubMed ID: 34636894
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Probing binding sites and mechanisms of action of an I(Ks) activator by computations and experiments.
    Xu Y; Wang Y; Zhang M; Jiang M; Rosenhouse-Dantsker A; Wassenaar T; Tseng GN
    Biophys J; 2015 Jan; 108(1):62-75. PubMed ID: 25564853
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Biophysical properties of mutant KCNQ1 S277L channels linked to hereditary long QT syndrome with phenotypic variability.
    Aidery P; Kisselbach J; Schweizer PA; Becker R; Katus HA; Thomas D
    Biochim Biophys Acta; 2011 Apr; 1812(4):488-94. PubMed ID: 21241800
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels.
    Seebohm G; Westenskow P; Lang F; Sanguinetti MC
    J Physiol; 2005 Mar; 563(Pt 2):359-68. PubMed ID: 15649981
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits.
    Franqueza L; Lin M; Shen J; Splawski I; Keating MT; Sanguinetti MC
    J Biol Chem; 1999 Jul; 274(30):21063-70. PubMed ID: 10409658
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome.
    Seebohm G; Scherer CR; Busch AE; Lerche C
    J Biol Chem; 2001 Apr; 276(17):13600-5. PubMed ID: 11278406
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The G314S KCNQ1 mutation exerts a dominant-negative effect on expression of KCNQ1 channels in oocytes.
    Li W; Du R; Wang QF; Tian L; Yang JG; Song ZF
    Biochem Biophys Res Commun; 2009 May; 383(2):206-9. PubMed ID: 19348785
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels.
    Seebohm G; Strutz-Seebohm N; Ureche ON; Henrion U; Baltaev R; Mack AF; Korniychuk G; Steinke K; Tapken D; Pfeufer A; Kääb S; Bucci C; Attali B; Merot J; Tavare JM; Hoppe UC; Sanguinetti MC; Lang F
    Circ Res; 2008 Dec; 103(12):1451-7. PubMed ID: 19008479
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels.
    Seebohm G; Pusch M; Chen J; Sanguinetti MC
    Circ Res; 2003 Nov; 93(10):941-7. PubMed ID: 14576198
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Clinical and electrophysiological characterization of a novel mutation (F193L) in the KCNQ1 gene associated with long QT syndrome.
    Yamaguchi M; Shimizu M; Ino H; Terai H; Hayashi K; Mabuchi H; Hoshi N; Higashida H
    Clin Sci (Lond); 2003 Apr; 104(4):377-82. PubMed ID: 12653681
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels.
    Seebohm G; Sanguinetti MC; Pusch M
    J Physiol; 2003 Oct; 552(Pt 2):369-78. PubMed ID: 14561821
    [TBL] [Abstract][Full Text] [Related]  

  • 18. KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.
    Choveau FS; Rodriguez N; Abderemane Ali F; Labro AJ; Rose T; Dahimène S; Boudin H; Le Hénaff C; Escande D; Snyders DJ; Charpentier F; Mérot J; Baró I; Loussouarn G
    J Biol Chem; 2011 Jan; 286(1):707-16. PubMed ID: 20940310
    [TBL] [Abstract][Full Text] [Related]  

  • 19. KCNQ1 and KCNH2 mutations associated with long QT syndrome in a Chinese population.
    Liu W; Yang J; Hu D; Kang C; Li C; Zhang S; Li P; Chen Z; Qin X; Ying K; Li Y; Li Y; Li Z; Cheng X; Li L; Qi Y; Chen S; Wang Q
    Hum Mutat; 2002 Dec; 20(6):475-6. PubMed ID: 12442276
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biophysical characteristics of a new mutation on the KCNQ1 potassium channel (L251P) causing long QT syndrome.
    Deschênes D; Acharfi S; Pouliot V; Hegele R; Krahn A; Daleau P; Chahine M
    Can J Physiol Pharmacol; 2003 Feb; 81(2):129-34. PubMed ID: 12710526
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.