BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

123 related articles for article (PubMed ID: 35772770)

  • 1. Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes.
    Yamazaki H; Shimizu M
    Drug Metab Dispos; 2023 Jan; 51(1):123-129. PubMed ID: 35772770
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.
    Chowdhury G; Murayama N; Okada Y; Uno Y; Shimizu M; Shibata N; Guengerich FP; Yamazaki H
    Chem Res Toxicol; 2010 Jun; 23(6):1018-24. PubMed ID: 20443640
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide.
    Chowdhury G; Shibata N; Yamazaki H; Guengerich FP
    Chem Res Toxicol; 2014 Jan; 27(1):147-56. PubMed ID: 24350712
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations.
    Murayama N; Yamazaki H
    J Toxicol Sci; 2021; 46(8):371-378. PubMed ID: 34334558
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans.
    Shimada T; Mimura M; Inoue K; Nakamura S; Oda H; Ohmori S; Yamazaki H
    Arch Toxicol; 1997; 71(6):401-8. PubMed ID: 9195021
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A convenient method to discriminate between cytochrome P450 enzymes and flavin-containing monooxygenases in human liver microsomes.
    Grothusen A; Hardt J; Bräutigam L; Lang D; Böcker R
    Arch Toxicol; 1996; 71(1-2):64-71. PubMed ID: 9010587
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models.
    Uno Y; Shimizu M; Yamazaki H
    Biochem Pharmacol; 2024 Mar; ():116124. PubMed ID: 38490520
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
    Patten CJ; Smith TJ; Murphy SE; Wang MH; Lee J; Tynes RE; Koch P; Yang CS
    Arch Biochem Biophys; 1996 Sep; 333(1):127-38. PubMed ID: 8806763
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).
    Uehara S; Uno Y; Inoue T; Murayama N; Shimizu M; Sasaki E; Yamazaki H
    Drug Metab Dispos; 2015 May; 43(5):735-42. PubMed ID: 25735838
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.
    Murayama N; Kazuki Y; Satoh D; Arata K; Harada T; Shibata N; Guengerich FP; Yamazaki H
    J Toxicol Sci; 2017; 42(3):343-348. PubMed ID: 28496040
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5'-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species.
    Kuwagata M; Hasegawa T; Takashima H; Shimizu M; Kitajima S; Yamazaki H
    J Toxicol Sci; 2021; 46(12):553-560. PubMed ID: 34853241
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes.
    Miura T; Uehara S; Shimizu M; Suemizu H; Yamazaki H
    J Toxicol Sci; 2021; 46(7):311-317. PubMed ID: 34193768
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cytochrome P450 dependent N-hydroxylation of a guanidine (debrisoquine), microsomal catalysed reduction and further oxidation of the N-hydroxy-guanidine metabolite to the urea derivative. Similarity with the oxidation of arginine to citrulline and nitric oxide.
    Clement B; Schultze-Mosgau MH; Wohlers H
    Biochem Pharmacol; 1993 Dec; 46(12):2249-67. PubMed ID: 8274159
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.
    Yamazaki H; Shaw PM; Guengerich FP; Shimada T
    Chem Res Toxicol; 1998 Jun; 11(6):659-65. PubMed ID: 9625734
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Thalidomide metabolism by the CYP2C subfamily.
    Ando Y; Fuse E; Figg WD
    Clin Cancer Res; 2002 Jun; 8(6):1964-73. PubMed ID: 12060642
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans.
    Uno Y; Uehara S; Yamazaki H
    Biochem Pharmacol; 2022 Mar; 197():114887. PubMed ID: 34968483
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes.
    Yamazaki H; Shimada T
    Xenobiotica; 1999 Mar; 29(3):231-41. PubMed ID: 10219964
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.
    Patten CJ; Smith TJ; Friesen MJ; Tynes RE; Yang CS; Murphy SE
    Carcinogenesis; 1997 Aug; 18(8):1623-30. PubMed ID: 9276639
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation.
    Born SL; Caudill D; Fliter KL; Purdon MP
    Drug Metab Dispos; 2002 May; 30(5):483-7. PubMed ID: 11950775
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.
    Yamazaki H; Inoue K; Mimura M; Oda Y; Guengerich FP; Shimada T
    Biochem Pharmacol; 1996 Feb; 51(3):313-9. PubMed ID: 8573198
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.