BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

238 related articles for article (PubMed ID: 35815941)

  • 1. Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context.
    Kerk SA; Lin L; Myers AL; Sutton DJ; Andren A; Sajjakulnukit P; Zhang L; Zhang Y; Jiménez JA; Nelson BS; Chen B; Robinson A; Thurston G; Kemp SB; Steele NG; Hoffman MT; Wen HJ; Long D; Ackenhusen SE; Ramos J; Gao X; Nwosu ZC; Galban S; Halbrook CJ; Lombard DB; Piwnica-Worms DR; Ying H; Pasca di Magliano M; Crawford HC; Shah YM; Lyssiotis CA
    Elife; 2022 Jul; 11():. PubMed ID: 35815941
    [TBL] [Abstract][Full Text] [Related]  

  • 2. SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.
    Yang H; Zhou L; Shi Q; Zhao Y; Lin H; Zhang M; Zhao S; Yang Y; Ling ZQ; Guan KL; Xiong Y; Ye D
    EMBO J; 2015 Apr; 34(8):1110-25. PubMed ID: 25755250
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ischemic Neuroprotectant PKCε Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury.
    Xu J; Khoury N; Jackson CW; Escobar I; Stegelmann SD; Dave KR; Perez-Pinzon MA
    Transl Stroke Res; 2020 Jun; 11(3):418-432. PubMed ID: 31473978
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy.
    van Karnebeek CDM; Ramos RJ; Wen XY; Tarailo-Graovac M; Gleeson JG; Skrypnyk C; Brand-Arzamendi K; Karbassi F; Issa MY; van der Lee R; Drögemöller BI; Koster J; Rousseau J; Campeau PM; Wang Y; Cao F; Li M; Ruiter J; Ciapaite J; Kluijtmans LAJ; Willemsen MAAP; Jans JJ; Ross CJ; Wintjes LT; Rodenburg RJ; Huigen MCDG; Jia Z; Waterham HR; Wasserman WW; Wanders RJA; Verhoeven-Duif NM; Zaki MS; Wevers RA
    Am J Hum Genet; 2019 Sep; 105(3):534-548. PubMed ID: 31422819
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition.
    Yang S; Hwang S; Kim M; Seo SB; Lee JH; Jeong SM
    Cell Death Dis; 2018 Jan; 9(2):55. PubMed ID: 29352139
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.
    Hong R; Zhang W; Xia X; Zhang K; Wang Y; Wu M; Fan J; Li J; Xia W; Xu F; Chen J; Wang S; Zhan Q
    Mol Oncol; 2019 Apr; 13(4):959-977. PubMed ID: 30714292
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Acetyl-CoA from inflammation-induced fatty acids oxidation promotes hepatic malate-aspartate shuttle activity and glycolysis.
    Wang T; Yao W; Li J; He Q; Shao Y; Huang F
    Am J Physiol Endocrinol Metab; 2018 Oct; 315(4):E496-E510. PubMed ID: 29763372
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A Cancer Cell-Intrinsic GOT2-PPARδ Axis Suppresses Antitumor Immunity.
    Abrego J; Sanford-Crane H; Oon C; Xiao X; Betts CB; Sun D; Nagarajan S; Diaz L; Sandborg H; Bhattacharyya S; Xia Z; Coussens LM; Tontonoz P; Sherman MH
    Cancer Discov; 2022 Oct; 12(10):2414-2433. PubMed ID: 35894778
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
    Son J; Lyssiotis CA; Ying H; Wang X; Hua S; Ligorio M; Perera RM; Ferrone CR; Mullarky E; Shyh-Chang N; Kang Y; Fleming JB; Bardeesy N; Asara JM; Haigis MC; DePinho RA; Cantley LC; Kimmelman AC
    Nature; 2013 Apr; 496(7443):101-5. PubMed ID: 23535601
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.
    Honorat JA; Nakatsuji Y; Shimizu M; Kinoshita M; Sumi-Akamaru H; Sasaki T; Takata K; Koda T; Namba A; Yamashita K; Sanda E; Sakaguchi M; Kumanogoh A; Shirakura T; Tamura M; Sakoda S; Mochizuki H; Okuno T
    PLoS One; 2017; 12(11):e0187215. PubMed ID: 29107957
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.
    Chakrabarti G; Moore ZR; Luo X; Ilcheva M; Ali A; Padanad M; Zhou Y; Xie Y; Burma S; Scaglioni PP; Cantley LC; DeBerardinis RJ; Kimmelman AC; Lyssiotis CA; Boothman DA
    Cancer Metab; 2015; 3():12. PubMed ID: 26462257
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
    Hu T; Shukla SK; Vernucci E; He C; Wang D; King RJ; Jha K; Siddhanta K; Mullen NJ; Attri KS; Murthy D; Chaika NV; Thakur R; Mulder SE; Pacheco CG; Fu X; High RR; Yu F; Lazenby A; Steegborn C; Lan P; Mehla K; Rotili D; Chaudhary S; Valente S; Tafani M; Mai A; Auwerx J; Verdin E; Tuveson D; Singh PK
    Gastroenterology; 2021 Nov; 161(5):1584-1600. PubMed ID: 34245764
    [TBL] [Abstract][Full Text] [Related]  

  • 13. KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth.
    Raho S; Capobianco L; Malivindi R; Vozza A; Piazzolla C; De Leonardis F; Gorgoglione R; Scarcia P; Pezzuto F; Agrimi G; Barile SN; Pisano I; Reshkin SJ; Greco MR; Cardone RA; Rago V; Li Y; Marobbio CMT; Sommergruber W; Riley CL; Lasorsa FM; Mills E; Vegliante MC; De Benedetto GE; Fratantonio D; Palmieri L; Dolce V; Fiermonte G
    Nat Metab; 2020 Dec; 2(12):1373-1381. PubMed ID: 33230296
    [TBL] [Abstract][Full Text] [Related]  

  • 14. GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors.
    Li Y; Li B; Xu Y; Qian L; Xu T; Meng G; Li H; Wang Y; Zhang L; Jiang X; Liu Q; Xie Y; Cheng C; Sun B; Yu D
    Cancer Res; 2022 Sep; 82(18):3223-3235. PubMed ID: 35895805
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.
    McDonald PC; Chafe SC; Brown WS; Saberi S; Swayampakula M; Venkateswaran G; Nemirovsky O; Gillespie JA; Karasinska JM; Kalloger SE; Supuran CT; Schaeffer DF; Bashashati A; Shah SP; Topham JT; Yapp DT; Li J; Renouf DJ; Stanger BZ; Dedhar S
    Gastroenterology; 2019 Sep; 157(3):823-837. PubMed ID: 31078621
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Metabolic plasticity in heterogeneous pancreatic ductal adenocarcinoma.
    Liang C; Qin Y; Zhang B; Ji S; Shi S; Xu W; Liu J; Xiang J; Liang D; Hu Q; Ni Q; Xu J; Yu X
    Biochim Biophys Acta; 2016 Dec; 1866(2):177-188. PubMed ID: 27600832
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mitochondrial uncoupler MB1-47 is efficacious in treating hepatic metastasis of pancreatic cancer in murine tumor transplantation models.
    Alasadi A; Cao B; Guo J; Tao H; Collantes J; Tan V; Su X; Augeri D; Jin S
    Oncogene; 2021 Mar; 40(12):2285-2295. PubMed ID: 33649533
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effects of glutamate oxaloacetate transaminase on reactive oxygen species in Ganoderma lucidum.
    Liu H; Qiao J; Shangguan J; Zhu J
    Appl Microbiol Biotechnol; 2023 Mar; 107(5-6):1845-1861. PubMed ID: 36754884
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts.
    Moatassim-Billah S; Duluc C; Samain R; Jean C; Perraud A; Decaup E; Cassant-Sourdy S; Bakri Y; Selves J; Schmid H; Martineau Y; Mathonnet M; Pyronnet S; Bousquet C
    Oncotarget; 2016 Jul; 7(27):41584-41598. PubMed ID: 27177087
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression.
    Feist M; Schwarzfischer P; Heinrich P; Sun X; Kemper J; von Bonin F; Perez-Rubio P; Taruttis F; Rehberg T; Dettmer K; Gronwald W; Reinders J; Engelmann JC; Dudek J; Klapper W; Trümper L; Spang R; Oefner PJ; Kube D
    Nat Commun; 2018 Apr; 9(1):1514. PubMed ID: 29666362
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.