BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 35906225)

  • 1. CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors.
    Lloyd SM; Leon DB; Brady MO; Rodriguez D; McReynolds MP; Kweon J; Neely AE; Blumensaadt LA; Ho PJ; Bao X
    Nat Commun; 2022 Jul; 13(1):4408. PubMed ID: 35906225
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Super elongation complex promotes early HIV transcription and its function is modulated by P-TEFb.
    Kuzmina A; Krasnopolsky S; Taube R
    Transcription; 2017 May; 8(3):133-149. PubMed ID: 28340332
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Disrupting the Cdk9/Cyclin T1 heterodimer of 7SK snRNP for the Brd4 and AFF1/4 guided reconstitution of active P-TEFb.
    Zhou K; Zhuang S; Liu F; Chen Y; Li Y; Wang S; Li Y; Wen H; Lin X; Wang J; Huang Y; He C; Xu N; Li Z; Xu L; Zhang Z; Chen LF; Chen R; Liu M
    Nucleic Acids Res; 2022 Jan; 50(2):750-762. PubMed ID: 34935961
    [TBL] [Abstract][Full Text] [Related]  

  • 4. AFF4 globally affects the release of paused RNA polymerase II in HEL cells.
    Yang ZM; Zhang G; Wei G; Jing LL; Yu M
    Yi Chuan; 2023 Aug; 45(8):658-668. PubMed ID: 37609817
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.
    Sansó M; Lee KM; Viladevall L; Jacques PÉ; Pagé V; Nagy S; Racine A; St Amour CV; Zhang C; Shokat KM; Schwer B; Robert F; Fisher RP; Tanny JC
    PLoS Genet; 2012; 8(8):e1002822. PubMed ID: 22876190
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.
    Liu P; Xiang Y; Fujinaga K; Bartholomeeusen K; Nilson KA; Price DH; Peterlin BM
    J Biol Chem; 2014 Apr; 289(14):9918-25. PubMed ID: 24515107
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.
    Lu H; Li Z; Zhang W; Schulze-Gahmen U; Xue Y; Zhou Q
    Nucleic Acids Res; 2015 Jul; 43(12):5868-79. PubMed ID: 26007649
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output.
    Luo Z; Lin C; Guest E; Garrett AS; Mohaghegh N; Swanson S; Marshall S; Florens L; Washburn MP; Shilatifard A
    Mol Cell Biol; 2012 Jul; 32(13):2608-17. PubMed ID: 22547686
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.
    Schulze-Gahmen U; Upton H; Birnberg A; Bao K; Chou S; Krogan NJ; Zhou Q; Alber T
    Elife; 2013 Mar; 2():e00327. PubMed ID: 23471103
    [TBL] [Abstract][Full Text] [Related]  

  • 10. T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
    Dow EC; Liu H; Rice AP
    J Cell Physiol; 2010 Jul; 224(1):84-93. PubMed ID: 20201073
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription.
    Kuzmina A; Verstraete N; Galker S; Maatook M; Bensaude O; Taube R
    Retrovirology; 2014 Jul; 11():51. PubMed ID: 24985467
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.
    Bartholomeeusen K; Xiang Y; Fujinaga K; Peterlin BM
    J Biol Chem; 2012 Oct; 287(43):36609-16. PubMed ID: 22952229
    [TBL] [Abstract][Full Text] [Related]  

  • 13. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.
    Lu H; Li Z; Xue Y; Schulze-Gahmen U; Johnson JR; Krogan NJ; Alber T; Zhou Q
    Proc Natl Acad Sci U S A; 2014 Jan; 111(1):E15-24. PubMed ID: 24367103
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4.
    Gu J; Babayeva ND; Suwa Y; Baranovskiy AG; Price DH; Tahirov TH
    Cell Cycle; 2014; 13(11):1788-97. PubMed ID: 24727379
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Distinct roles of the two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA Pol II transcription elongation.
    Che Z; Liu X; Dai Q; Fang K; Guo C; Yue J; Fang H; Xie P; Luo Z; Lin C
    J Mol Cell Biol; 2023 Aug; ():. PubMed ID: 37528066
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.
    Michels AA; Fraldi A; Li Q; Adamson TE; Bonnet F; Nguyen VT; Sedore SC; Price JP; Price DH; Lania L; Bensaude O
    EMBO J; 2004 Jul; 23(13):2608-19. PubMed ID: 15201869
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition.
    Albert TK; Antrecht C; Kremmer E; Meisterernst M
    PLoS One; 2016; 11(1):e0146648. PubMed ID: 26745862
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II.
    Parua PK; Booth GT; Sansó M; Benjamin B; Tanny JC; Lis JT; Fisher RP
    Nature; 2018 Jun; 558(7710):460-464. PubMed ID: 29899453
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo.
    Pei Y; Du H; Singer J; Stamour C; Granitto S; Shuman S; Fisher RP
    Mol Cell Biol; 2006 Feb; 26(3):777-88. PubMed ID: 16428435
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of P-TEFb elongation complex activity by CDK9 acetylation.
    Fu J; Yoon HG; Qin J; Wong J
    Mol Cell Biol; 2007 Jul; 27(13):4641-51. PubMed ID: 17452463
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.