BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 35956979)

  • 21. Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.
    Yadav AA; Wu X; Patel D; Yalowich JC; Hasinoff BB
    Bioorg Med Chem; 2014 Nov; 22(21):5935-49. PubMed ID: 25282653
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors.
    El-Adl K; El-Helby AA; Sakr H; Elwan A
    Bioorg Chem; 2020 Dec; 105():104399. PubMed ID: 33113414
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity.
    Kassab AE; Gedawy EM
    Eur J Med Chem; 2018 Apr; 150():403-418. PubMed ID: 29547830
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors.
    Sathish M; Kavitha B; Nayak VL; Tangella Y; Ajitha A; Nekkanti S; Alarifi A; Shankaraiah N; Nagesh N; Kamal A
    Eur J Med Chem; 2018 Jan; 144():557-571. PubMed ID: 29289881
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents.
    Kamal A; Kumar BA; Suresh P; Juvekar A; Zingde S
    Bioorg Med Chem; 2011 May; 19(9):2975-9. PubMed ID: 21489802
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison.
    Kunwar S; Hwang SY; Katila P; Park S; Jeon KH; Kim D; Kadayat TM; Kwon Y; Lee ES
    Eur J Med Chem; 2021 Dec; 226():113860. PubMed ID: 34597897
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Discovery of novel triazolophthalazine derivatives as DNA intercalators and topoisomerase II inhibitors.
    Sakr H; Ayyad RR; El-Helby AA; Khalifa MM; Mahdy HA
    Arch Pharm (Weinheim); 2021 Jun; 354(6):e2000456. PubMed ID: 33554352
    [TBL] [Abstract][Full Text] [Related]  

  • 28. One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH₂SO₃H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents.
    Shankaraiah N; Kumar NP; Amula SB; Nekkanti S; Jeengar MK; Naidu VG; Reddy TS; Kamal A
    Bioorg Med Chem Lett; 2015 Oct; 25(19):4239-44. PubMed ID: 26292628
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Antitumor agents. II: Regio- and stereospecific syntheses of 1-beta-alkyl-1-desoxypodophyllotoxin derivatives and biological activity.
    Terada T; Fujimoto K; Nomura M; Yamashita J; Wierzba K; Kobunai T; Takeda S; Minami Y; Yoshida K; Yamaguchi H
    Chem Pharm Bull (Tokyo); 1993 May; 41(5):907-12. PubMed ID: 8393386
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors.
    Yao BL; Mai YW; Chen SB; Xie HT; Yao PF; Ou TM; Tan JH; Wang HG; Li D; Huang SL; Gu LQ; Huang ZS
    Eur J Med Chem; 2015 Mar; 92():540-53. PubMed ID: 25599951
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
    Lee KH; Beers SA; Mori M; Wang ZQ; Kuo YH; Li L; Liu SY; Chang JY; Han FS; Cheng YC
    J Med Chem; 1990 May; 33(5):1364-8. PubMed ID: 2158562
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Synthesis and evaluation of (18)F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression.
    Daumar P; Zeglis BM; Ramos N; Divilov V; Sevak KK; Pillarsetty N; Lewis JS
    Eur J Med Chem; 2014 Oct; 86():769-81. PubMed ID: 25240701
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities.
    Kamal A; Kumar BA; Suresh P; Agrawal SK; Chashoo G; Singh SK; Saxena AK
    Bioorg Med Chem; 2010 Dec; 18(24):8493-500. PubMed ID: 21074444
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discovery of 1,2-diphenylethene derivatives as human DNA topoisomerase II catalytic inhibitors and antitumor agents.
    Xu G; Li Z; Ding Y; Shen Y
    Eur J Med Chem; 2022 Dec; 243():114706. PubMed ID: 36063665
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and
    Khalifa MM; Al-Karmalawy AA; Elkaeed EB; Nafie MS; Tantawy MA; Eissa IH; Mahdy HA
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):299-314. PubMed ID: 34894955
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors.
    My Van HT; Woo H; Jeong HM; Khadka DB; Yang SH; Zhao C; Jin Y; Lee ES; Youl Lee K; Kwon Y; Cho WJ
    Eur J Med Chem; 2014 Jul; 82():181-94. PubMed ID: 24904965
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers.
    Li PH; Jiang H; Zhang WJ; Li YL; Zhao MC; Zhou W; Zhang LY; Tang YD; Dong CZ; Huang ZS; Chen HX; Du ZY
    Eur J Med Chem; 2018 Feb; 145():498-510. PubMed ID: 29335211
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors.
    Eissa IH; Metwaly AM; Belal A; Mehany ABM; Ayyad RR; El-Adl K; Mahdy HA; Taghour MS; El-Gamal KMA; El-Sawah ME; Elmetwally SA; Elhendawy MA; Radwan MM; ElSohly MA
    Arch Pharm (Weinheim); 2019 Nov; 352(11):e1900123. PubMed ID: 31463953
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Antitumor agents. 3. Synthesis and biological activity of 4 beta-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.
    Terada T; Fujimoto K; Nomura M; Yamashita J; Wierzba K; Yamazaki R; Shibata J; Sugimoto Y; Yamada Y; Kobunai T
    J Med Chem; 1993 Jun; 36(12):1689-99. PubMed ID: 8389875
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Novel carbamate derivatives of 4-beta-amino-4'-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation.
    Duca M; Arimondo PB; Léonce S; Pierré A; Pfeiffer B; Monneret C; Dauzonne D
    Org Biomol Chem; 2005 Mar; 3(6):1074-80. PubMed ID: 15750651
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.