BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 35994671)

  • 1. Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.
    Feldman HC; Merlini E; Guijas C; DeMeester KE; Njomen E; Kozina EM; Yokoyama M; Vinogradova E; Reardon HT; Melillo B; Schreiber SL; Loreto A; Blankman JL; Cravatt BF
    Proc Natl Acad Sci U S A; 2022 Aug; 119(35):e2208457119. PubMed ID: 35994671
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
    Shi Y; Kerry PS; Nanson JD; Bosanac T; Sasaki Y; Krauss R; Saikot FK; Adams SE; Mosaiab T; Masic V; Mao X; Rose F; Vasquez E; Furrer M; Cunnea K; Brearley A; Gu W; Luo Z; Brillault L; Landsberg MJ; DiAntonio A; Kobe B; Milbrandt J; Hughes RO; Ve T
    Mol Cell; 2022 May; 82(9):1643-1659.e10. PubMed ID: 35334231
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection.
    Sasaki Y; Zhu J; Shi Y; Gu W; Kobe B; Ve T; DiAntonio A; Milbrandt J
    Exp Neurol; 2021 Nov; 345():113842. PubMed ID: 34403688
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The NAD
    Jiang Y; Liu T; Lee CH; Chang Q; Yang J; Zhang Z
    Nature; 2020 Dec; 588(7839):658-663. PubMed ID: 33053563
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Multiple domain interfaces mediate SARM1 autoinhibition.
    Shen C; Vohra M; Zhang P; Mao X; Figley MD; Zhu J; Sasaki Y; Wu H; DiAntonio A; Milbrandt J
    Proc Natl Acad Sci U S A; 2021 Jan; 118(4):. PubMed ID: 33468661
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD
    Essuman K; Summers DW; Sasaki Y; Mao X; DiAntonio A; Milbrandt J
    Neuron; 2017 Mar; 93(6):1334-1343.e5. PubMed ID: 28334607
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of the first noncompetitive SARM1 inhibitors.
    Loring HS; Parelkar SS; Mondal S; Thompson PR
    Bioorg Med Chem; 2020 Sep; 28(18):115644. PubMed ID: 32828421
    [TBL] [Abstract][Full Text] [Related]  

  • 8. SARM1 is a metabolic sensor activated by an increased NMN/NAD
    Figley MD; Gu W; Nanson JD; Shi Y; Sasaki Y; Cunnea K; Malde AK; Jia X; Luo Z; Saikot FK; Mosaiab T; Masic V; Holt S; Hartley-Tassell L; McGuinness HY; Manik MK; Bosanac T; Landsberg MJ; Kerry PS; Mobli M; Hughes RO; Milbrandt J; Kobe B; DiAntonio A; Ve T
    Neuron; 2021 Apr; 109(7):1118-1136.e11. PubMed ID: 33657413
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The chemical biology of NAD
    Icso JD; Thompson PR
    Curr Opin Chem Biol; 2022 Aug; 69():102176. PubMed ID: 35780654
    [TBL] [Abstract][Full Text] [Related]  

  • 10. SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.
    Gerdts J; Brace EJ; Sasaki Y; DiAntonio A; Milbrandt J
    Science; 2015 Apr; 348(6233):453-7. PubMed ID: 25908823
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy.
    Bosanac T; Hughes RO; Engber T; Devraj R; Brearley A; Danker K; Young K; Kopatz J; Hermann M; Berthemy A; Boyce S; Bentley J; Krauss R
    Brain; 2021 Nov; 144(10):3226-3238. PubMed ID: 33964142
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate.
    Li WH; Huang K; Cai Y; Wang QW; Zhu WJ; Hou YN; Wang S; Cao S; Zhao ZY; Xie XJ; Du Y; Lee CS; Lee HC; Zhang H; Zhao YJ
    Elife; 2021 May; 10():. PubMed ID: 33944777
    [TBL] [Abstract][Full Text] [Related]  

  • 13. SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.
    Summers DW; Gibson DA; DiAntonio A; Milbrandt J
    Proc Natl Acad Sci U S A; 2016 Oct; 113(41):E6271-E6280. PubMed ID: 27671644
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
    Loreto A; Angeletti C; Gu W; Osborne A; Nieuwenhuis B; Gilley J; Merlini E; Arthur-Farraj P; Amici A; Luo Z; Hartley-Tassell L; Ve T; Desrochers LM; Wang Q; Kobe B; Orsomando G; Coleman MP
    Elife; 2021 Dec; 10():. PubMed ID: 34870595
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.
    Wu T; Zhu J; Strickland A; Ko KW; Sasaki Y; Dingwall CB; Yamada Y; Figley MD; Mao X; Neiner A; Bloom AJ; DiAntonio A; Milbrandt J
    Cell Rep; 2021 Oct; 37(3):109872. PubMed ID: 34686345
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity.
    Brace EJ; Essuman K; Mao X; Palucki J; Sasaki Y; Milbrandt J; DiAntonio A
    PLoS Genet; 2022 Jun; 18(6):e1010246. PubMed ID: 35737728
    [TBL] [Abstract][Full Text] [Related]  

  • 17. SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.
    Miyamoto T; Kim C; Chow J; Dugas JC; DeGroot J; Bagdasarian AL; Thottumkara AP; Larhammar M; Calvert ME; Fox BM; Lewcock JW; Kane LA
    J Biol Chem; 2024 Feb; 300(2):105630. PubMed ID: 38199568
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival.
    Ademi M; Yang X; Coleman MP; Gilley J
    Sci Rep; 2022 Aug; 12(1):13846. PubMed ID: 35974060
    [TBL] [Abstract][Full Text] [Related]  

  • 19. SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration.
    Chen YH; Sasaki Y; DiAntonio A; Milbrandt J
    Exp Neurol; 2021 May; 339():113636. PubMed ID: 33548217
    [TBL] [Abstract][Full Text] [Related]  

  • 20. cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons.
    Sasaki Y; Engber TM; Hughes RO; Figley MD; Wu T; Bosanac T; Devraj R; Milbrandt J; Krauss R; DiAntonio A
    Exp Neurol; 2020 Jul; 329():113252. PubMed ID: 32087251
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.