146 related articles for article (PubMed ID: 36030831)
1. IMP075 targeting ClpP for colon cancer therapy in vivo and in vitro.
Zhang J; Luo B; Sui J; Qiu Z; Huang J; Yang T; Luo Y
Biochem Pharmacol; 2022 Oct; 204():115232. PubMed ID: 36030831
[TBL] [Abstract][Full Text] [Related]
2. Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues.
Graves PR; Aponte-Collazo LJ; Fennell EMJ; Graves AC; Hale AE; Dicheva N; Herring LE; Gilbert TSK; East MP; McDonald IM; Lockett MR; Ashamalla H; Moorman NJ; Karanewsky DS; Iwanowicz EJ; Holmuhamedov E; Graves LM
ACS Chem Biol; 2019 May; 14(5):1020-1029. PubMed ID: 31021596
[TBL] [Abstract][Full Text] [Related]
3. Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpP.
Fennell EMJ; Aponte-Collazo LJ; Wynn JD; Drizyte-Miller K; Leung E; Greer YE; Graves PR; Iwanowicz AA; Ashamalla H; Holmuhamedov E; Lang H; Karanewsky DS; Der CJ; Houry WA; Lipkowitz S; Iwanowicz EJ; Graves LM
Pharmacol Res Perspect; 2022 Aug; 10(4):e00993. PubMed ID: 35929764
[TBL] [Abstract][Full Text] [Related]
4. Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis.
Greer YE; Hernandez L; Fennell EMJ; Kundu M; Voeller D; Chari R; Gilbert SF; Gilbert TSK; Ratnayake S; Tang B; Hafner M; Chen Q; Meerzaman D; Iwanowicz E; Annunziata CM; Graves LM; Lipkowitz S
Cancer Res Commun; 2022 Oct; 2(10):1144-1161. PubMed ID: 36388465
[TBL] [Abstract][Full Text] [Related]
5. ONC201 and imipridones: Anti-cancer compounds with clinical efficacy.
Prabhu VV; Morrow S; Rahman Kawakibi A; Zhou L; Ralff M; Ray J; Jhaveri A; Ferrarini I; Lee Y; Parker C; Zhang Y; Borsuk R; Chang WI; Honeyman JN; Tavora F; Carneiro B; Raufi A; Huntington K; Carlsen L; Louie A; Safran H; Seyhan AA; Tarapore RS; Schalop L; Stogniew M; Allen JE; Oster W; El-Deiry WS
Neoplasia; 2020 Dec; 22(12):725-744. PubMed ID: 33142238
[TBL] [Abstract][Full Text] [Related]
6. Myricetin protects mice against MRSA-related lethal pneumonia by targeting ClpP.
Jing S; Wang L; Wang T; Fan L; Chen L; Xiang H; Shi Y; Wang D
Biochem Pharmacol; 2021 Oct; 192():114753. PubMed ID: 34474040
[TBL] [Abstract][Full Text] [Related]
7. Caseinolytic protease P (CLPP) activated by ONC201 inhibits proliferation and promotes apoptosis in human epithelial ovarian cancer cells by inducing mitochondrial dysfunction.
Kou X; Ding H; Li L; Chao H
Ann Transl Med; 2021 Sep; 9(18):1463. PubMed ID: 34734015
[TBL] [Abstract][Full Text] [Related]
8. Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.
Fennell EMJ; Aponte-Collazo LJ; Pathmasiri W; Rushing BR; Barker NK; Partridge MC; Li YY; White CA; Greer YE; Herring LE; Lipkowitz S; Sumner SCJ; Iwanowicz EJ; Graves LM
Front Pharmacol; 2023; 14():1136317. PubMed ID: 37063293
[TBL] [Abstract][Full Text] [Related]
9. CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis.
Rumyantseva A; Popovic M; Trifunovic A
Brain; 2022 Mar; 145(1):92-104. PubMed ID: 35240691
[TBL] [Abstract][Full Text] [Related]
10. Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer.
Cormio A; Sanguedolce F; Pesce V; Musicco C
Int J Mol Sci; 2021 Jun; 22(12):. PubMed ID: 34207660
[TBL] [Abstract][Full Text] [Related]
11. Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Ishizawa J; Zarabi SF; Davis RE; Halgas O; Nii T; Jitkova Y; Zhao R; St-Germain J; Heese LE; Egan G; Ruvolo VR; Barghout SH; Nishida Y; Hurren R; Ma W; Gronda M; Link T; Wong K; Mabanglo M; Kojima K; Borthakur G; MacLean N; Ma MCJ; Leber AB; Minden MD; Houry W; Kantarjian H; Stogniew M; Raught B; Pai EF; Schimmer AD; Andreeff M
Cancer Cell; 2019 May; 35(5):721-737.e9. PubMed ID: 31056398
[TBL] [Abstract][Full Text] [Related]
12. Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists.
Zhang R; Wang P; Wei B; Chen L; Song X; Pan Y; Li J; Gan J; Zhang T; Yang CG
Eur J Med Chem; 2023 Oct; 258():115577. PubMed ID: 37352796
[TBL] [Abstract][Full Text] [Related]
13. Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma.
Wang P; Zhang T; Wang X; Xiao H; Li H; Zhou LL; Yang T; Wei B; Zhu Z; Zhou L; Yang S; Lu X; Zhang Y; Huang Y; Gan J; Yang CG
Cell Chem Biol; 2022 Sep; 29(9):1396-1408.e8. PubMed ID: 35905743
[TBL] [Abstract][Full Text] [Related]
14. Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.
Druzhyna N; Szczesny B; Olah G; Módis K; Asimakopoulou A; Pavlidou A; Szoleczky P; Gerö D; Yanagi K; Törö G; López-García I; Myrianthopoulos V; Mikros E; Zatarain JR; Chao C; Papapetropoulos A; Hellmich MR; Szabo C
Pharmacol Res; 2016 Nov; 113(Pt A):18-37. PubMed ID: 27521834
[TBL] [Abstract][Full Text] [Related]
15. Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma.
Nguyen TTT; Shang E; Schiffgens S; Torrini C; Shu C; Akman HO; Prabhu VV; Allen JE; Westhoff MA; Karpel-Massler G; Siegelin MD
Clin Cancer Res; 2022 May; 28(9):1881-1895. PubMed ID: 35417530
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Cole A; Wang Z; Coyaud E; Voisin V; Gronda M; Jitkova Y; Mattson R; Hurren R; Babovic S; Maclean N; Restall I; Wang X; Jeyaraju DV; Sukhai MA; Prabha S; Bashir S; Ramakrishnan A; Leung E; Qia YH; Zhang N; Combes KR; Ketela T; Lin F; Houry WA; Aman A; Al-Awar R; Zheng W; Wienholds E; Xu CJ; Dick J; Wang JC; Moffat J; Minden MD; Eaves CJ; Bader GD; Hao Z; Kornblau SM; Raught B; Schimmer AD
Cancer Cell; 2015 Jun; 27(6):864-76. PubMed ID: 26058080
[TBL] [Abstract][Full Text] [Related]
17. ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis.
Guo C; Xiao Y; Gu J; Zhao P; Hu Z; Zheng J; Hua R; Hai Z; Su J; Zhang JV; Yeung WSB; Wang T
Commun Biol; 2023 Oct; 6(1):1012. PubMed ID: 37798322
[TBL] [Abstract][Full Text] [Related]
18. Pathological mutations promote proteolysis of mitochondrial tRNA-specific 2-thiouridylase 1 (MTU1) via mitochondrial caseinolytic peptidase (CLPP).
Ahmad RNR; Zhang LT; Morita R; Tani H; Wu Y; Chujo T; Ogawa A; Harada R; Shigeta Y; Tomizawa K; Wei FY
Nucleic Acids Res; 2024 Feb; 52(3):1341-1358. PubMed ID: 38113276
[TBL] [Abstract][Full Text] [Related]
19. Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.
Jacques S; van der Sloot AM; C Huard C; Coulombe-Huntington J; Tsao S; Tollis S; Bertomeu T; Culp EJ; Pallant D; Cook MA; Bonneil E; Thibault P; Wright GD; Tyers M
Genetics; 2020 Apr; 214(4):1103-1120. PubMed ID: 32094149
[TBL] [Abstract][Full Text] [Related]
20. Mitochondrial Unfolded Protein Response Gene
Ergun Y; Imamoglu AG; Cozzolino M; Demirkiran C; Basar M; Garg A; Yildirim RM; Seli E
Int J Mol Sci; 2024 Feb; 25(3):. PubMed ID: 38339144
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
