163 related articles for article (PubMed ID: 36051621)
1. Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1.
Zhao XZ; Wang W; Lountos GT; Tropea JE; Needle D; Pommier Y; Burke TR
Front Chem; 2022; 10():910953. PubMed ID: 36051621
[TBL] [Abstract][Full Text] [Related]
2. Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification.
Zhao XZ; Wang W; Lountos GT; Kiselev E; Tropea JE; Needle D; Pommier Y; Burke TR
RSC Chem Biol; 2023 May; 4(5):334-343. PubMed ID: 37181631
[TBL] [Abstract][Full Text] [Related]
3. Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites.
Zhao XZ; Kiselev E; Lountos GT; Wang W; Tropea JE; Needle D; Hilimire TA; Schneekloth JS; Waugh DS; Pommier Y; Burke TR
Chem Sci; 2021 Jan; 12(11):3876-3884. PubMed ID: 34163656
[TBL] [Abstract][Full Text] [Related]
4. Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.
Lountos GT; Zhao XZ; Kiselev E; Tropea JE; Needle D; Pommier Y; Burke TR; Waugh DS
Nucleic Acids Res; 2019 Nov; 47(19):10134-10150. PubMed ID: 31199869
[TBL] [Abstract][Full Text] [Related]
5. Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3'-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1).
Tsuda M; Kitamasu K; Kumagai C; Sugiyama K; Nakano T; Ide H
DNA Repair (Amst); 2020; 91-92():102849. PubMed ID: 32460231
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors.
Liao Z; Thibaut L; Jobson A; Pommier Y
Mol Pharmacol; 2006 Jul; 70(1):366-72. PubMed ID: 16618796
[TBL] [Abstract][Full Text] [Related]
7. Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity.
Zakharenko A; Dyrkheeva N; Lavrik O
Med Res Rev; 2019 Jul; 39(4):1427-1441. PubMed ID: 31004352
[TBL] [Abstract][Full Text] [Related]
8. New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.
Dyrkheeva NS; Filimonov AS; Luzina OA; Orlova KA; Chernyshova IA; Kornienko TE; Malakhova AA; Medvedev SP; Zakharenko AL; Ilina ES; Anarbaev RO; Naumenko KN; Klabenkova KV; Burakova EA; Stetsenko DA; Zakian SM; Salakhutdinov NF; Lavrik OI
Int J Mol Sci; 2021 Oct; 22(21):. PubMed ID: 34768766
[TBL] [Abstract][Full Text] [Related]
9. Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
Davies DR; Interthal H; Champoux JJ; Hol WG
J Mol Biol; 2002 Dec; 324(5):917-32. PubMed ID: 12470949
[TBL] [Abstract][Full Text] [Related]
10. Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
Dexheimer TS; Antony S; Marchand C; Pommier Y
Anticancer Agents Med Chem; 2008 May; 8(4):381-9. PubMed ID: 18473723
[TBL] [Abstract][Full Text] [Related]
11. TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
Zeng Z; Sharma A; Ju L; Murai J; Umans L; Vermeire L; Pommier Y; Takeda S; Huylebroeck D; Caldecott KW; El-Khamisy SF
Nucleic Acids Res; 2012 Sep; 40(17):8371-80. PubMed ID: 22740648
[TBL] [Abstract][Full Text] [Related]
12. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
Zhang XR; Wang HW; Tang WL; Zhang Y; Yang H; Hu DX; Ravji A; Marchand C; Kiselev E; Ofori-Atta K; Agama K; Pommier Y; An LK
J Med Chem; 2018 Nov; 61(22):9908-9930. PubMed ID: 30336023
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.
Lv PC; Agama K; Marchand C; Pommier Y; Cushman M
J Med Chem; 2014 May; 57(10):4324-36. PubMed ID: 24800942
[TBL] [Abstract][Full Text] [Related]
14. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential.
Laev SS; Salakhutdinov NF; Lavrik OI
Bioorg Med Chem; 2016 Nov; 24(21):5017-5027. PubMed ID: 27687971
[TBL] [Abstract][Full Text] [Related]
15. A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.
Jakobsen AK; Keller JG; Gonzalez M; Martin-Encinas E; Palacios F; Alonso C; Knudsen BR; Stougaard M
Sensors (Basel); 2021 Jul; 21(14):. PubMed ID: 34300575
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2).
Wang P; Elsayed MSA; Plescia CB; Ravji A; Redon CE; Kiselev E; Marchand C; Zeleznik O; Agama K; Pommier Y; Cushman M
J Med Chem; 2017 Apr; 60(8):3275-3288. PubMed ID: 28418653
[TBL] [Abstract][Full Text] [Related]
17. Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue.
Jakobsen AK; Lauridsen KL; Samuel EB; Proszek J; Knudsen BR; Hager H; Stougaard M
Exp Mol Pathol; 2015 Aug; 99(1):56-64. PubMed ID: 25987486
[TBL] [Abstract][Full Text] [Related]
18. Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.
Murai J; Marchand C; Shahane SA; Sun H; Huang R; Zhang Y; Chergui A; Ji J; Doroshow JH; Jadhav A; Takeda S; Xia M; Pommier Y
DNA Repair (Amst); 2014 Sep; 21():177-82. PubMed ID: 24794403
[TBL] [Abstract][Full Text] [Related]
19. 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.
Sirivolu VR; Vernekar SK; Marchand C; Naumova A; Chergui A; Renaud A; Stephen AG; Chen F; Sham YY; Pommier Y; Wang Z
J Med Chem; 2012 Oct; 55(20):8671-84. PubMed ID: 23006064
[TBL] [Abstract][Full Text] [Related]
20. Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.
Marchand C; Lea WA; Jadhav A; Dexheimer TS; Austin CP; Inglese J; Pommier Y; Simeonov A
Mol Cancer Ther; 2009 Jan; 8(1):240-8. PubMed ID: 19139134
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]