BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

224 related articles for article (PubMed ID: 36121025)

  • 1. Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.
    Petit D; Hitzenberger M; Koch M; Lismont S; Zoltowska KM; Enzlein T; Hopf C; Zacharias M; Chávez-Gutiérrez L
    EMBO J; 2022 Nov; 41(21):e111084. PubMed ID: 36121025
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
    Liu L; Lauro BM; Wolfe MS; Selkoe DJ
    J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
    Page RM; Gutsmiedl A; Fukumori A; Winkler E; Haass C; Steiner H
    J Biol Chem; 2010 Jun; 285(23):17798-810. PubMed ID: 20348104
    [TBL] [Abstract][Full Text] [Related]  

  • 4. How Modulator Binding at the Amyloidβ-γ-Secretase Interface Enhances Substrate Binding and Attenuates Membrane Distortion.
    Chen SY; Koch M; Chávez-Gutiérrez L; Zacharias M
    J Med Chem; 2023 Dec; 66(24):16772-16782. PubMed ID: 38059872
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel γ-secretase enzyme modulators directly target presenilin protein.
    Ebke A; Luebbers T; Fukumori A; Shirotani K; Haass C; Baumann K; Steiner H
    J Biol Chem; 2011 Oct; 286(43):37181-6. PubMed ID: 21896486
    [TBL] [Abstract][Full Text] [Related]  

  • 6. First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.
    Borgegard T; Juréus A; Olsson F; Rosqvist S; Sabirsh A; Rotticci D; Paulsen K; Klintenberg R; Yan H; Waldman M; Stromberg K; Nord J; Johansson J; Regner A; Parpal S; Malinowsky D; Radesater AC; Li T; Singh R; Eriksson H; Lundkvist J
    J Biol Chem; 2012 Apr; 287(15):11810-9. PubMed ID: 22334705
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators.
    Petit D; Hitzenberger M; Lismont S; Zoltowska KM; Ryan NS; Mercken M; Bischoff F; Zacharias M; Chávez-Gutiérrez L
    EMBO J; 2019 Jun; 38(12):. PubMed ID: 31109937
    [TBL] [Abstract][Full Text] [Related]  

  • 8. APP substrate ectodomain defines amyloid-β peptide length by restraining γ-secretase processivity and facilitating product release.
    Koch M; Enzlein T; Chen SY; Petit D; Lismont S; Zacharias M; Hopf C; Chávez-Gutiérrez L
    EMBO J; 2023 Dec; 42(23):e114372. PubMed ID: 37853914
    [TBL] [Abstract][Full Text] [Related]  

  • 9. γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.
    Weber TA; Lundkvist J; Wanngren J; Kvartsberg H; Jin S; Larssen P; Wu D; Oliveira DV; Minta K; Brinkmalm G; Zetterberg H; Blennow K; Nordvall G; Winblad B; Portelius E; Karlström H
    J Cell Mol Med; 2022 Feb; 26(3):880-892. PubMed ID: 34931449
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Substrate-targeting gamma-secretase modulators.
    Kukar TL; Ladd TB; Bann MA; Fraering PC; Narlawar R; Maharvi GM; Healy B; Chapman R; Welzel AT; Price RW; Moore B; Rangachari V; Cusack B; Eriksen J; Jansen-West K; Verbeeck C; Yager D; Eckman C; Ye W; Sagi S; Cottrell BA; Torpey J; Rosenberry TL; Fauq A; Wolfe MS; Schmidt B; Walsh DM; Koo EH; Golde TE
    Nature; 2008 Jun; 453(7197):925-9. PubMed ID: 18548070
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
    Blain JF; Bursavich MG; Freeman EA; Hrdlicka LA; Hodgdon HE; Chen T; Costa DE; Harrison BA; Kapadnis S; Murphy DA; Nolan S; Tu Z; Tang C; Burnett DA; Patzke H; Koenig G
    Alzheimers Res Ther; 2016 Aug; 8(1):34. PubMed ID: 27572246
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development and mechanism of γ-secretase modulators for Alzheimer's disease.
    Crump CJ; Johnson DS; Li YM
    Biochemistry; 2013 May; 52(19):3197-216. PubMed ID: 23614767
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).
    Park HJ; Shabashvili D; Nekorchuk MD; Shyqyriu E; Jung JI; Ladd TB; Moore BD; Felsenstein KM; Golde TE; Kim SH
    J Biol Chem; 2012 Nov; 287(48):40629-40. PubMed ID: 23043097
    [TBL] [Abstract][Full Text] [Related]  

  • 15. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
    Scannevin RH; Chollate S; Brennan MS; Snodgrass-Belt PA; Peng H; Xu L; Jung MY; Bussiere T; Arastu MF; Talreja T; Xin Z; Dunstan RW; Fahrer D; Rohde E; Dunah AW; Wang J; Kumaravel G; Taveras AG; Moore Arnold H; Rhodes KJ
    Neuropharmacology; 2016 Apr; 103():57-68. PubMed ID: 26690893
    [TBL] [Abstract][Full Text] [Related]  

  • 16. γ-Secretase in Alzheimer's disease.
    Hur JY
    Exp Mol Med; 2022 Apr; 54(4):433-446. PubMed ID: 35396575
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.
    Gerber H; Wu F; Dimitrov M; Garcia Osuna GM; Fraering PC
    J Biol Chem; 2017 Mar; 292(9):3751-3767. PubMed ID: 28096459
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease.
    Svedružić ZM; Popović K; Smoljan I; Sendula-Jengić V
    PLoS One; 2012; 7(3):e32293. PubMed ID: 22479317
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo.
    Huang Y; Li T; Eatherton A; Mitchell WL; Rong N; Ye L; Yang XJ; Jin S; Ding Y; Zhang J; Li Y; Wu Y; Jin Y; Sang Y; Cheng Z; Browne ER; Harrison DC; Hussain I; Wan Z; Hall A; Lau LF; Matsuoka Y
    Neuropharmacology; 2013 Jul; 70():278-86. PubMed ID: 23485401
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.
    Bolduc DM; Montagna DR; Seghers MC; Wolfe MS; Selkoe DJ
    Elife; 2016 Aug; 5():. PubMed ID: 27580372
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.