172 related articles for article (PubMed ID: 36122209)
1. Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer.
Liu F; Gai X; Wu Y; Zhang B; Wu X; Cheng R; Tang B; Shang K; Zhao N; Deng W; Chen J; Zhang Z; Gu S; Zheng L; Zhang H
Proc Natl Acad Sci U S A; 2022 Sep; 119(39):e2202157119. PubMed ID: 36122209
[No Abstract] [Full Text] [Related]
2. Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis.
Liu F; Wu Y; Zhang B; Yang S; Shang K; Li J; Zhang P; Deng W; Chen L; Zheng L; Gai X; Zhang H
Chin Med J (Engl); 2024 Jan; 137(2):181-189. PubMed ID: 37612257
[TBL] [Abstract][Full Text] [Related]
3. Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.
Sato T; Akasu H; Shimono W; Matsu C; Fujiwara Y; Shibagaki Y; Heard JJ; Tamanoi F; Hattori S
J Biol Chem; 2015 Jan; 290(2):1096-105. PubMed ID: 25422319
[TBL] [Abstract][Full Text] [Related]
4. Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.
Robitaille AM; Christen S; Shimobayashi M; Cornu M; Fava LL; Moes S; Prescianotto-Baschong C; Sauer U; Jenoe P; Hall MN
Science; 2013 Mar; 339(6125):1320-3. PubMed ID: 23429704
[TBL] [Abstract][Full Text] [Related]
5. Pyrimidine Biosynthetic Enzyme CAD: Its Function, Regulation, and Diagnostic Potential.
Li G; Li D; Wang T; He S
Int J Mol Sci; 2021 Sep; 22(19):. PubMed ID: 34638594
[TBL] [Abstract][Full Text] [Related]
6. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Ben-Sahra I; Howell JJ; Asara JM; Manning BD
Science; 2013 Mar; 339(6125):1323-8. PubMed ID: 23429703
[TBL] [Abstract][Full Text] [Related]
7. CAD, A Multienzymatic Protein at the Head of de Novo Pyrimidine Biosynthesis.
Del Caño-Ochoa F; Moreno-Morcillo M; Ramón-Maiques S
Subcell Biochem; 2019; 93():505-538. PubMed ID: 31939163
[TBL] [Abstract][Full Text] [Related]
8. β-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β-catenin and MET.
Liang Y; Feng Y; Zong M; Wei XF; Lee J; Feng Y; Li H; Yang GS; Wu ZJ; Fu XD; Feng GS
Hepatology; 2018 May; 67(5):1807-1822. PubMed ID: 29152756
[TBL] [Abstract][Full Text] [Related]
9. Uracil nucleotide synthesis in a human breast cancer cell line (MCF-7) and in two drug-resistant sublines that contain increased levels of enzymes of the de novo pyrimidine pathway.
Karle JM; Cowan KH; Chisena CA; Cysyk RL
Mol Pharmacol; 1986 Aug; 30(2):136-41. PubMed ID: 2874477
[TBL] [Abstract][Full Text] [Related]
10. TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis.
Liang B; Zhou Y; Qian M; Xu M; Wang J; Zhang Y; Song X; Wang H; Lin S; Ren C; Monga SP; Wang B; Evert M; Chen Y; Chen X; Huang Z; Calvisi DF; Chen X
J Hepatol; 2021 Jul; 75(1):120-131. PubMed ID: 33577921
[TBL] [Abstract][Full Text] [Related]
11. Nucleotide sequence and tissue-specific expression of the multifunctional protein carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase (CAD) mRNA in Squalus acanthias.
Hong J; Salo WL; Anderson PM
J Biol Chem; 1995 Jun; 270(23):14130-9. PubMed ID: 7775474
[TBL] [Abstract][Full Text] [Related]
12. Cell cycle-dependent regulation of pyrimidine biosynthesis.
Sigoillot FD; Berkowski JA; Sigoillot SM; Kotsis DH; Guy HI
J Biol Chem; 2003 Jan; 278(5):3403-9. PubMed ID: 12438317
[TBL] [Abstract][Full Text] [Related]
13. Immunochemical analysis of the domain structure of CAD, the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells.
Grayson DR; Lee L; Evans DR
J Biol Chem; 1985 Dec; 260(29):15840-9. PubMed ID: 2866187
[TBL] [Abstract][Full Text] [Related]
14. Effect of high-protein diet on pyrimidine synthesis and response to PALA in mouse tissues.
Zaharevitz DW; Grubb MF; Hyman R; Chisena C; Cysyk RL
J Natl Cancer Inst; 1993 Apr; 85(8):662-6. PubMed ID: 8468725
[TBL] [Abstract][Full Text] [Related]
15. Regulation of carbamoyl phosphate synthetase by MAP kinase.
Graves LM; Guy HI; Kozlowski P; Huang M; Lazarowski E; Pope RM; Collins MA; Dahlstrand EN; Earp HS; Evans DR
Nature; 2000 Jan; 403(6767):328-32. PubMed ID: 10659854
[TBL] [Abstract][Full Text] [Related]
16. Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors.
Ng BG; Wolfe LA; Ichikawa M; Markello T; He M; Tifft CJ; Gahl WA; Freeze HH
Hum Mol Genet; 2015 Jun; 24(11):3050-7. PubMed ID: 25678555
[TBL] [Abstract][Full Text] [Related]
17. Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.
Iwahana H; Fujimura M; Ii S; Kondo M; Moritani M; Takahashi Y; Yamaoka T; Yoshimoto K; Itakura M
Biochem Biophys Res Commun; 1996 Feb; 219(1):249-55. PubMed ID: 8619816
[TBL] [Abstract][Full Text] [Related]
18. Oncogenic Mutations in Armadillo Repeats 5 and 6 of β-Catenin Reduce Binding to APC, Increasing Signaling and Transcription of Target Genes.
Liu P; Liang B; Liu M; Lebbink JHG; Li S; Qian M; Lavrijsen M; Peppelenbosch MP; Chen X; Smits R
Gastroenterology; 2020 Mar; 158(4):1029-1043.e10. PubMed ID: 31857074
[TBL] [Abstract][Full Text] [Related]
19. The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD.
Lindsey-Boltz LA; Wauson EM; Graves LM; Sancar A
Nucleic Acids Res; 2004; 32(15):4524-30. PubMed ID: 15326225
[TBL] [Abstract][Full Text] [Related]
20. Deciphering CAD: Structure and function of a mega-enzymatic pyrimidine factory in health and disease.
Del Caño-Ochoa F; Ramón-Maiques S
Protein Sci; 2021 Oct; 30(10):1995-2008. PubMed ID: 34288185
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
