BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

133 related articles for article (PubMed ID: 36137181)

  • 1. Mechanism of Action and Structure-Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor.
    Liang J; Tae HS; Zhao Z; Li X; Zhang J; Chen S; Jiang T; Adams DJ; Yu R
    J Med Chem; 2022 Dec; 65(24):16204-16217. PubMed ID: 36137181
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?
    Mohammadi SA; Christie MJ
    Toxins (Basel); 2015 Sep; 7(10):3916-32. PubMed ID: 26426047
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor.
    Halai R; Clark RJ; Nevin ST; Jensen JE; Adams DJ; Craik DJ
    J Biol Chem; 2009 Jul; 284(30):20275-84. PubMed ID: 19447885
    [TBL] [Abstract][Full Text] [Related]  

  • 4. α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement.
    Chu X; Tae HS; Xu Q; Jiang T; Adams DJ; Yu R
    ACS Chem Neurosci; 2019 Oct; 10(10):4328-4336. PubMed ID: 31411453
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes.
    Wang S; Zhao C; Liu Z; Wang X; Liu N; Du W; Dai Q
    Mar Drugs; 2015 May; 13(6):3259-75. PubMed ID: 26023835
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Interaction of rat α9α10 nicotinic acetylcholine receptor with α-conotoxin RgIA and Vc1.1: Insights from docking, molecular dynamics and binding free energy contributions.
    Li R; Li X; Jiang J; Tian Y; Liu D; Zhangsun D; Fu Y; Wu Y; Luo S
    J Mol Graph Model; 2019 Nov; 92():55-64. PubMed ID: 31330438
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype.
    Yu R; Tae HS; Tabassum N; Shi J; Jiang T; Adams DJ
    J Med Chem; 2018 May; 61(10):4628-4634. PubMed ID: 29733583
    [TBL] [Abstract][Full Text] [Related]  

  • 8. αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.
    Zhangsun D; Zhu X; Kaas Q; Wu Y; Craik DJ; McIntosh JM; Luo S
    Neuropharmacology; 2017 Dec; 127():243-252. PubMed ID: 28416445
    [TBL] [Abstract][Full Text] [Related]  

  • 9. αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors.
    Christensen SB; Bandyopadhyay PK; Olivera BM; McIntosh JM
    Biochem Pharmacol; 2015 Aug; 96(4):349-56. PubMed ID: 26074268
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors.
    McIntosh JM; Plazas PV; Watkins M; Gomez-Casati ME; Olivera BM; Elgoyhen AB
    J Biol Chem; 2005 Aug; 280(34):30107-12. PubMed ID: 15983035
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Globular and ribbon isomers of Conus geographus α-conotoxins antagonize human nicotinic acetylcholine receptors.
    Tae HS; Gao B; Jin AH; Alewood PF; Adams DJ
    Biochem Pharmacol; 2021 Aug; 190():114638. PubMed ID: 34062129
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-Activity Studies Reveal the Molecular Basis for GABA
    Sadeghi M; Carstens BB; Callaghan BP; Daniel JT; Tae HS; O'Donnell T; Castro J; Brierley SM; Adams DJ; Craik DJ; Clark RJ
    ACS Chem Biol; 2018 Jun; 13(6):1577-1587. PubMed ID: 29746088
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric-dependent action of the α-conotoxin, Vc1.1.
    Indurthi DC; Pera E; Kim HL; Chu C; McLeod MD; McIntosh JM; Absalom NL; Chebib M
    Biochem Pharmacol; 2014 May; 89(1):131-40. PubMed ID: 24548457
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dual Antagonism of α9α10 nAChR and GABA
    Li X; Tae HS; Chen S; Yousuf A; Huang L; Zhang J; Jiang T; Adams DJ; Yu R
    J Med Chem; 2024 Jan; 67(2):971-987. PubMed ID: 38217860
    [TBL] [Abstract][Full Text] [Related]  

  • 15. From Crystal Structures of RgIA4 in Complex with
    Pan S; Fan Y; Zhu X; Xue Y; Luo S; Wang X
    Mar Drugs; 2021 Dec; 19(12):. PubMed ID: 34940708
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models.
    Kryukova EV; Ivanov IA; Lebedev DS; Spirova EN; Egorova NS; Zouridakis M; Kasheverov IE; Tzartos SJ; Tsetlin VI
    Mar Drugs; 2018 Nov; 16(12):. PubMed ID: 30469507
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.
    Luo S; Zhangsun D; Harvey PJ; Kaas Q; Wu Y; Zhu X; Hu Y; Li X; Tsetlin VI; Christensen S; Romero HK; McIntyre M; Dowell C; Baxter JC; Elmslie KS; Craik DJ; McIntosh JM
    Proc Natl Acad Sci U S A; 2015 Jul; 112(30):E4026-35. PubMed ID: 26170295
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery and Structural and Functional Characterization of a Novel A-Superfamily Conotoxin Targeting α9α10 Nicotinic Acetylcholine Receptor.
    Huang Q; Chu X; Zhang H; Yu S; Zhang L; Zhang X; Yu R; Guo C; Dai Q
    ACS Chem Biol; 2022 Sep; 17(9):2483-2494. PubMed ID: 36048451
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA.
    Xu P; Kaas Q; Wu Y; Zhu X; Li X; Harvey PJ; Zhangsun D; Craik DJ; Luo S
    J Med Chem; 2020 Feb; 63(4):1564-1575. PubMed ID: 31986036
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues.
    Ellison M; Feng ZP; Park AJ; Zhang X; Olivera BM; McIntosh JM; Norton RS
    J Mol Biol; 2008 Apr; 377(4):1216-27. PubMed ID: 18295795
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.