212 related articles for article (PubMed ID: 36160437)
1. Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells.
Krchniakova M; Paukovcekova S; Chlapek P; Neradil J; Skoda J; Veselska R
Front Pharmacol; 2022; 13():976955. PubMed ID: 36160437
[TBL] [Abstract][Full Text] [Related]
2. The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.
Kovacevic Z; Menezes SV; Sahni S; Kalinowski DS; Bae DH; Lane DJ; Richardson DR
J Biol Chem; 2016 Jan; 291(3):1029-52. PubMed ID: 26534963
[TBL] [Abstract][Full Text] [Related]
3. Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms.
Paukovcekova S; Skoda J; Neradil J; Mikulenkova E; Chlapek P; Sterba J; Richardson DR; Veselska R
Cancers (Basel); 2020 Dec; 12(12):. PubMed ID: 33334021
[TBL] [Abstract][Full Text] [Related]
4. Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.
Wangpu X; Lu J; Xi R; Yue F; Sahni S; Park KC; Menezes S; Huang ML; Zheng M; Kovacevic Z; Richardson DR
Mol Pharmacol; 2016 May; 89(5):521-40. PubMed ID: 26895766
[TBL] [Abstract][Full Text] [Related]
5. Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding.
Park KC; Geleta B; Leck LYW; Paluncic J; Chiang S; Jansson PJ; Kovacevic Z; Richardson DR
J Biol Chem; 2020 Jan; 295(2):481-503. PubMed ID: 31744884
[TBL] [Abstract][Full Text] [Related]
6. Innovative therapies for neuroblastoma: The surprisingly potent role of iron chelation in up-regulating metastasis and tumor suppressors and down-regulating the key oncogene, N-myc.
Wijesinghe TP; Dharmasivam M; Dai CC; Richardson DR
Pharmacol Res; 2021 Nov; 173():105889. PubMed ID: 34536548
[TBL] [Abstract][Full Text] [Related]
7. Iron-Chelation Treatment by Novel Thiosemicarbazone Targets Major Signaling Pathways in Neuroblastoma.
Macsek P; Skoda J; Krchniakova M; Neradil J; Veselska R
Int J Mol Sci; 2021 Dec; 23(1):. PubMed ID: 35008802
[TBL] [Abstract][Full Text] [Related]
8. Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.
Fang BA; Kovačević Ž; Park KC; Kalinowski DS; Jansson PJ; Lane DJ; Sahni S; Richardson DR
Biochim Biophys Acta; 2014 Jan; 1845(1):1-19. PubMed ID: 24269900
[TBL] [Abstract][Full Text] [Related]
9. Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).
Xi R; Pun IH; Menezes SV; Fouani L; Kalinowski DS; Huang ML; Zhang X; Richardson DR; Kovacevic Z
Mol Pharmacol; 2017 May; 91(5):499-517. PubMed ID: 28275050
[TBL] [Abstract][Full Text] [Related]
10. The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.
Guo ZL; Richardson DR; Kalinowski DS; Kovacevic Z; Tan-Un KC; Chan GC
J Hematol Oncol; 2016 Sep; 9(1):98. PubMed ID: 27678372
[TBL] [Abstract][Full Text] [Related]
11. The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.
Sahni S; Bae DH; Lane DJ; Kovacevic Z; Kalinowski DS; Jansson PJ; Richardson DR
J Biol Chem; 2014 Apr; 289(14):9692-709. PubMed ID: 24532803
[TBL] [Abstract][Full Text] [Related]
12. The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells.
Dharmasivam M; Azad MG; Afroz R; Richardson V; Jansson PJ; Richardson DR
Biochim Biophys Acta Gen Subj; 2022 Aug; 1866(8):130152. PubMed ID: 35436509
[TBL] [Abstract][Full Text] [Related]
13. Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion.
Lui GY; Kovacevic Z; V Menezes S; Kalinowski DS; Merlot AM; Sahni S; Richardson DR
Mol Pharmacol; 2015; 87(3):543-60. PubMed ID: 25561562
[TBL] [Abstract][Full Text] [Related]
14. Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect.
Quach P; Gutierrez E; Basha MT; Kalinowski DS; Sharpe PC; Lovejoy DB; Bernhardt PV; Jansson PJ; Richardson DR
Mol Pharmacol; 2012 Jul; 82(1):105-14. PubMed ID: 22508546
[TBL] [Abstract][Full Text] [Related]
15. The Role of Extracellular Proteases in Tumor Progression and the Development of Innovative Metal Ion Chelators that Inhibit their Activity.
Park KC; Dharmasivam M; Richardson DR
Int J Mol Sci; 2020 Sep; 21(18):. PubMed ID: 32948029
[TBL] [Abstract][Full Text] [Related]
16. Iron chelator-induced up-regulation of Ndrg1 inhibits proliferation and EMT process by targeting Wnt/β-catenin pathway in colon cancer cells.
Chen Z; Sun J; Li T; Liu Y; Gao S; Zhi X; Zheng M
Biochem Biophys Res Commun; 2018 Nov; 506(1):114-121. PubMed ID: 30340826
[TBL] [Abstract][Full Text] [Related]
17. The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response.
Merlot AM; Porter GM; Sahni S; Lim EG; Peres P; Richardson DR
Biochim Biophys Acta Mol Basis Dis; 2019 Sep; 1865(9):2094-2110. PubMed ID: 30981813
[TBL] [Abstract][Full Text] [Related]
18. Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway.
Sun J; Zhang D; Zheng Y; Zhao Q; Zheng M; Kovacevic Z; Richardson DR
Mol Pharmacol; 2013 Feb; 83(2):454-69. PubMed ID: 23188716
[TBL] [Abstract][Full Text] [Related]
19. The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).
Chen Z; Zhang D; Yue F; Zheng M; Kovacevic Z; Richardson DR
J Biol Chem; 2012 May; 287(21):17016-17028. PubMed ID: 22453918
[TBL] [Abstract][Full Text] [Related]
20. Breaking the cycle: Targeting of NDRG1 to inhibit bi-directional oncogenic cross-talk between pancreatic cancer and stroma.
Geleta B; Park KC; Jansson PJ; Sahni S; Maleki S; Xu Z; Murakami T; Pajic M; Apte MV; Richardson DR; Kovacevic Z
FASEB J; 2021 Feb; 35(2):e21347. PubMed ID: 33484481
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
