These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 36189349)

  • 1.
    Rudraraju RS; Daher SS; Gallardo-Macias R; Wang X; Neiditch MB; Freundlich JS
    Front Cell Infect Microbiol; 2022; 12():1008213. PubMed ID: 36189349
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA.
    Kumar P; Capodagli GC; Awasthi D; Shrestha R; Maharaja K; Sukheja P; Li SG; Inoyama D; Zimmerman M; Ho Liang HP; Sarathy J; Mina M; Rasic G; Russo R; Perryman AL; Richmann T; Gupta A; Singleton E; Verma S; Husain S; Soteropoulos P; Wang Z; Morris R; Porter G; Agnihotri G; Salgame P; Ekins S; Rhee KY; Connell N; Dartois V; Neiditch MB; Freundlich JS; Alland D
    mBio; 2018 Dec; 9(6):. PubMed ID: 30563908
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.
    Inoyama D; Awasthi D; Capodagli GC; Tsotetsi K; Sukheja P; Zimmerman M; Li SG; Jadhav R; Russo R; Wang X; Grady C; Richmann T; Shrestha R; Li L; Ahn YM; Ho Liang HP; Mina M; Park S; Perlin DS; Connell N; Dartois V; Alland D; Neiditch MB; Kumar P; Freundlich JS
    Cell Chem Biol; 2020 May; 27(5):560-570.e10. PubMed ID: 32197094
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB.
    Schaeffer ML; Agnihotri G; Volker C; Kallender H; Brennan PJ; Lonsdale JT
    J Biol Chem; 2001 Dec; 276(50):47029-37. PubMed ID: 11600501
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
    Larsen MH; Vilchèze C; Kremer L; Besra GS; Parsons L; Salfinger M; Heifets L; Hazbon MH; Alland D; Sacchettini JC; Jacobs WR
    Mol Microbiol; 2002 Oct; 46(2):453-66. PubMed ID: 12406221
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid.
    Mdluli K; Slayden RA; Zhu Y; Ramaswamy S; Pan X; Mead D; Crane DD; Musser JM; Barry CE
    Science; 1998 Jun; 280(5369):1607-10. PubMed ID: 9616124
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis.
    Slayden RA; Lee RE; Barry CE
    Mol Microbiol; 2000 Nov; 38(3):514-25. PubMed ID: 11069675
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in Singapore.
    Lee AS; Lim IH; Tang LL; Telenti A; Wong SY
    Antimicrob Agents Chemother; 1999 Aug; 43(8):2087-9. PubMed ID: 10428945
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural insight into conformational dynamics of non-active site mutations in KasA: A Mycobacterium tuberculosis target protein.
    Jayaraman M; Rajendra SK; Ramadas K
    Gene; 2019 Dec; 720():144082. PubMed ID: 31476406
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin.
    Luckner SR; Machutta CA; Tonge PJ; Kisker C
    Structure; 2009 Jul; 17(7):1004-13. PubMed ID: 19604480
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The β-ketoacyl-ACP synthase from Mycobacterium tuberculosis as potential drug targets.
    Singh V; Mani I; Chaudhary DK; Somvanshi P
    Curr Med Chem; 2011; 18(9):1318-24. PubMed ID: 21370994
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.
    Lee W; Luckner SR; Kisker C; Tonge PJ; Engels B
    Biochemistry; 2011 Jun; 50(25):5743-56. PubMed ID: 21615093
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Clarification on the decarboxylation mechanism in KasA based on the protonation state of key residues in the acyl-enzyme state.
    Lee W; Engels B
    J Phys Chem B; 2013 Jul; 117(27):8095-104. PubMed ID: 23768199
    [TBL] [Abstract][Full Text] [Related]  

  • 14. X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).
    Sridharan S; Wang L; Brown AK; Dover LG; Kremer L; Besra GS; Sacchettini JC
    J Mol Biol; 2007 Feb; 366(2):469-80. PubMed ID: 17174327
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular dynamics of Mycobacterium tuberculosis KasA: implications for inhibitor and substrate binding and consequences for drug design.
    Schaefer B; Kisker C; Sotriffer CA
    J Comput Aided Mol Des; 2011 Nov; 25(11):1053-69. PubMed ID: 22076471
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of KasA as the cellular target of an anti-tubercular scaffold.
    Abrahams KA; Chung CW; Ghidelli-Disse S; Rullas J; Rebollo-López MJ; Gurcha SS; Cox JA; Mendoza A; Jiménez-Navarro E; Martínez-Martínez MS; Neu M; Shillings A; Homes P; Argyrou A; Casanueva R; Loman NJ; Moynihan PJ; Lelièvre J; Selenski C; Axtman M; Kremer L; Bantscheff M; Angulo-Barturen I; Izquierdo MC; Cammack NC; Drewes G; Ballell L; Barros D; Besra GS; Bates RH
    Nat Commun; 2016 Sep; 7():12581. PubMed ID: 27581223
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In Silico Drug Design of Thiolactomycin Derivatives Against Mtb-KasA Enzyme to Inhibit Multidrug Resistance of Mycobacterium tuberculosis.
    Durairaj DR; Shanmughavel P
    Interdiscip Sci; 2019 Jun; 11(2):215-225. PubMed ID: 28856604
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy.
    Kapilashrami K; Bommineni GR; Machutta CA; Kim P; Lai CT; Simmerling C; Picart F; Tonge PJ
    J Biol Chem; 2013 Mar; 288(9):6045-52. PubMed ID: 23306195
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Development of a scintillation proximity assay for the Mycobacterium tuberculosis KasA and KasB enzymes involved in mycolic acid biosynthesis.
    Schaeffer ML; Carson JD; Kallender H; Lonsdale JT
    Tuberculosis (Edinb); 2004; 84(6):353-60. PubMed ID: 15525558
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
    Kremer L; Dover LG; Morbidoni HR; Vilchèze C; Maughan WN; Baulard A; Tu SC; Honoré N; Deretic V; Sacchettini JC; Locht C; Jacobs WR; Besra GS
    J Biol Chem; 2003 Jun; 278(23):20547-54. PubMed ID: 12654922
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.