These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

181 related articles for article (PubMed ID: 36196170)

  • 1. DRUGGING "UNDRUGGABLE" DISEASE-CAUSING PROTEINS: FOCUS ON SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STAT) 3.
    Tweardy DJ
    Trans Am Clin Climatol Assoc; 2022; 132():61-76. PubMed ID: 36196170
    [TBL] [Abstract][Full Text] [Related]  

  • 2. TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain.
    Kasembeli MM; Singhmar P; Ma J; Edralin J; Tang Y; Adams C; Heijnen CJ; Kavelaars A; Tweardy DJ
    Biochem Pharmacol; 2021 Oct; 192():114688. PubMed ID: 34274354
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization.
    Resetca D; Haftchenary S; Gunning PT; Wilson DJ
    J Biol Chem; 2014 Nov; 289(47):32538-47. PubMed ID: 25288792
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural Implications of STAT3 and STAT5 SH2 Domain Mutations.
    de Araujo ED; Orlova A; Neubauer HA; Bajusz D; Seo HS; Dhe-Paganon S; Keserű GM; Moriggl R; Gunning PT
    Cancers (Basel); 2019 Nov; 11(11):. PubMed ID: 31717342
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
    Page BD; Khoury H; Laister RC; Fletcher S; Vellozo M; Manzoli A; Yue P; Turkson J; Minden MD; Gunning PT
    J Med Chem; 2012 Feb; 55(3):1047-55. PubMed ID: 22148584
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation.
    Szelag M; Czerwoniec A; Wesoly J; Bluyssen HA
    PLoS One; 2015; 10(2):e0116688. PubMed ID: 25710482
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors.
    Furtek SL; Matheson CJ; Backos DS; Reigan P
    Oncotarget; 2016 Nov; 7(47):77998-78008. PubMed ID: 27793003
    [TBL] [Abstract][Full Text] [Related]  

  • 8. High-throughput thermofluor-based assays for inhibitor screening of STAT SH2 domains.
    de Araujo ED; Manaswiyoungkul P; Israelian J; Park J; Yuen K; Farhangi S; Berger-Becvar A; Abu-Jazar L; Gunning PT
    J Pharm Biomed Anal; 2017 Sep; 143():159-167. PubMed ID: 28600954
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins.
    Takakuma K; Ogo N; Uehara Y; Takahashi S; Miyoshi N; Asai A
    PLoS One; 2013; 8(8):e71646. PubMed ID: 23977103
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Validating Signal Transducer and Activator of Transcription (STAT) Protein-Inhibitor Interactions Using Biochemical and Cellular Thermal Shift Assays.
    Attarha S; Reithmeier A; Busker S; Desroses M; Page BDG
    ACS Chem Biol; 2020 Jul; 15(7):1842-1851. PubMed ID: 32412740
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.
    Mandal PK; Gao F; Lu Z; Ren Z; Ramesh R; Birtwistle JS; Kaluarachchi KK; Chen X; Bast RC; Liao WS; McMurray JS
    J Med Chem; 2011 May; 54(10):3549-63. PubMed ID: 21486047
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease.
    Zhang L; Wang Y; Dong Y; Chen Z; Eckols TK; Kasembeli MM; Tweardy DJ; Mitch WE
    Am J Physiol Renal Physiol; 2020 Jul; 319(1):F84-F92. PubMed ID: 32475130
    [TBL] [Abstract][Full Text] [Related]  

  • 13. SH2 domain binding to phosphopeptide ligands: potential for drug targeting.
    Kasembeli MM; Xu X; Tweardy DJ
    Front Biosci (Landmark Ed); 2009 Jan; 14(3):1010-22. PubMed ID: 19273114
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility.
    Kong R; Bharadwaj U; Eckols TK; Kolosov M; Wu H; Cruz-Pavlovich FJS; Shaw A; Ifelayo OI; Zhao H; Kasembeli MM; Wong STC; Tweardy DJ
    Pharmacol Res; 2021 Jul; 169():105637. PubMed ID: 33932608
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo.
    Huang W; Dong Z; Chen Y; Wang F; Wang CJ; Peng H; He Y; Hangoc G; Pollok K; Sandusky G; Fu XY; Broxmeyer HE; Zhang ZY; Liu JY; Zhang JT
    Oncogene; 2016 Feb; 35(6):783-92. PubMed ID: 26073084
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3).
    Mandal PK; Ren Z; Chen X; Kaluarachchi K; Liao WS; McMurray JS
    Int J Pept Res Ther; 2013 Mar; 19(1):3-12. PubMed ID: 24707243
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Allosteric Communication across STAT3 Domains Associated with STAT3 Function and Disease-Causing Mutation.
    Namanja AT; Wang J; Buettner R; Colson L; Chen Y
    J Mol Biol; 2016 Feb; 428(3):579-589. PubMed ID: 26774853
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Screening of potent STAT3-SH2 domain inhibitors from JAK/STAT compound library through molecular dynamics simulation.
    Manoharan S; Balakrishnan A; Hemamalini V; Perumal E
    Mol Divers; 2023 Jun; 27(3):1297-1308. PubMed ID: 35831728
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Exploring dual inhibitors for STAT1 and STAT5 receptors utilizing virtual screening and dynamics simulation validation.
    Raj U; Kumar H; Gupta S; Varadwaj PK
    J Biomol Struct Dyn; 2016 Oct; 34(10):2115-29. PubMed ID: 26471877
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural basis for the binding of high affinity phosphopeptides to Stat3.
    McMurray JS
    Biopolymers; 2008; 90(1):69-79. PubMed ID: 18058821
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.