BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

241 related articles for article (PubMed ID: 36202848)

  • 1. Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology.
    Navarro-Romero A; Fernandez-Gonzalez I; Riera J; Montpeyo M; Albert-Bayo M; Lopez-Royo T; Castillo-Sanchez P; Carnicer-Caceres C; Arranz-Amo JA; Castillo-Ribelles L; Pradas E; Casas J; Vila M; Martinez-Vicente M
    NPJ Parkinsons Dis; 2022 Oct; 8(1):126. PubMed ID: 36202848
    [TBL] [Abstract][Full Text] [Related]  

  • 2.
    Smith L; Schapira AHV
    Cells; 2022 Apr; 11(8):. PubMed ID: 35455941
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation.
    Galvagnion C; Marlet FR; Cerri S; Schapira AHV; Blandini F; Di Monte DA
    Brain; 2022 Apr; 145(3):1038-1051. PubMed ID: 35362022
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
    Kuo SH; Tasset I; Cheng MM; Diaz A; Pan MK; Lieberman OJ; Hutten SJ; Alcalay RN; Kim S; Ximénez-Embún P; Fan L; Kim D; Ko HS; Yacoubian T; Kanter E; Liu L; Tang G; Muñoz J; Sardi SP; Li A; Gan L; Cuervo AM; Sulzer D
    Sci Adv; 2022 Feb; 8(6):eabm6393. PubMed ID: 35138901
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Consequences of GBA Deficiency in the Autophagy-Lysosome System in Parkinson's Disease Associated with GBA.
    Pradas E; Martinez-Vicente M
    Cells; 2023 Jan; 12(1):. PubMed ID: 36611984
    [No Abstract]   [Full Text] [Related]  

  • 6. Glucocerebrosidase Mutations Cause Mitochondrial and Lysosomal Dysfunction in Parkinson's Disease: Pathogenesis and Therapeutic Implications.
    Zheng W; Fan D
    Front Aging Neurosci; 2022; 14():851135. PubMed ID: 35401150
    [TBL] [Abstract][Full Text] [Related]  

  • 7. LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease.
    Pang SY; Lo RCN; Ho PW; Liu HF; Chang EES; Leung CT; Malki Y; Choi ZY; Wong WY; Kung MH; Ramsden DB; Ho SL
    Transl Neurodegener; 2022 Jan; 11(1):5. PubMed ID: 35101134
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.
    Smith LJ; Bolsinger MM; Chau KY; Gegg ME; Schapira AHV
    Hum Mol Genet; 2023 Feb; 32(5):773-789. PubMed ID: 36130205
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The role of glucocerebrosidase in Parkinson disease pathogenesis.
    Gegg ME; Schapira AHV
    FEBS J; 2018 Oct; 285(19):3591-3603. PubMed ID: 29385658
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
    Mazzulli JR; Zunke F; Tsunemi T; Toker NJ; Jeon S; Burbulla LF; Patnaik S; Sidransky E; Marugan JJ; Sue CM; Krainc D
    J Neurosci; 2016 Jul; 36(29):7693-706. PubMed ID: 27445146
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson's disease and their targeted therapeutic approaches: a comprehensive review.
    Behl T; Kaur G; Fratila O; Buhas C; Judea-Pusta CT; Negrut N; Bustea C; Bungau S
    Transl Neurodegener; 2021 Jan; 10(1):4. PubMed ID: 33446243
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration.
    Polissidis A; Koronaiou E; Nikolopoulou G; Viel C; Nikatou M; Bogiongko M; Sardi SP; Xilouri M; Vekrellis K; Stefanis L
    Neurobiol Dis; 2022 Feb; 163():105612. PubMed ID: 34995756
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease.
    Murphy KE; Gysbers AM; Abbott SK; Tayebi N; Kim WS; Sidransky E; Cooper A; Garner B; Halliday GM
    Brain; 2014 Mar; 137(Pt 3):834-48. PubMed ID: 24477431
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Glucocerebrosidase-associated Parkinson disease: Pathogenic mechanisms and potential drug treatments.
    Gegg ME; Menozzi E; Schapira AHV
    Neurobiol Dis; 2022 May; 166():105663. PubMed ID: 35183702
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells.
    Dermentzaki G; Dimitriou E; Xilouri M; Michelakakis H; Stefanis L
    PLoS One; 2013; 8(4):e60674. PubMed ID: 23580063
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease.
    Magalhaes J; Gegg ME; Migdalska-Richards A; Doherty MK; Whitfield PD; Schapira AH
    Hum Mol Genet; 2016 Aug; 25(16):3432-3445. PubMed ID: 27378698
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mitochondrial dysfunction associated with glucocerebrosidase deficiency.
    Gegg ME; Schapira AH
    Neurobiol Dis; 2016 Jun; 90():43-50. PubMed ID: 26388395
    [TBL] [Abstract][Full Text] [Related]  

  • 18. [GBA mutations and Parkinson's disease].
    Wang DX; Xie JX; Song N
    Sheng Li Xue Bao; 2018 Jun; 70(3):294-300. PubMed ID: 29926071
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.
    Rocha EM; Smith GA; Park E; Cao H; Brown E; Hayes MA; Beagan J; McLean JR; Izen SC; Perez-Torres E; Hallett PJ; Isacson O
    Neurobiol Dis; 2015 Oct; 82():495-503. PubMed ID: 26392287
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.
    Taguchi YV; Liu J; Ruan J; Pacheco J; Zhang X; Abbasi J; Keutzer J; Mistry PK; Chandra SS
    J Neurosci; 2017 Oct; 37(40):9617-9631. PubMed ID: 28847804
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.