These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

220 related articles for article (PubMed ID: 36207292)

  • 1. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
    Boland S; Swarup S; Ambaw YA; Malia PC; Richards RC; Fischer AW; Singh S; Aggarwal G; Spina S; Nana AL; Grinberg LT; Seeley WW; Surma MA; Klose C; Paulo JA; Nguyen AD; Harper JW; Walther TC; Farese RV
    Nat Commun; 2022 Oct; 13(1):5924. PubMed ID: 36207292
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
    Huang M; Modeste E; Dammer E; Merino P; Taylor G; Duong DM; Deng Q; Holler CJ; Gearing M; Dickson D; Seyfried NT; Kukar T
    Acta Neuropathol Commun; 2020 Oct; 8(1):163. PubMed ID: 33028409
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by
    Holler CJ; Taylor G; Deng Q; Kukar T
    eNeuro; 2017; 4(4):. PubMed ID: 28828399
    [TBL] [Abstract][Full Text] [Related]  

  • 4. New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.
    Amin S; Carling G; Gan L
    Curr Opin Neurobiol; 2022 Feb; 72():131-139. PubMed ID: 34826653
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD.
    Wu Y; Shao W; Todd TW; Tong J; Yue M; Koga S; Castanedes-Casey M; Librero AL; Lee CW; Mackenzie IR; Dickson DW; Zhang YJ; Petrucelli L; Prudencio M
    Cell Rep; 2021 Aug; 36(8):109581. PubMed ID: 34433069
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia.
    Sung W; Noh MY; Nahm M; Kim YS; Ki CS; Kim YE; Kim HJ; Kim SH
    J Neuroinflammation; 2024 Feb; 21(1):47. PubMed ID: 38347588
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
    Logan T; Simon MJ; Rana A; Cherf GM; Srivastava A; Davis SS; Low RLY; Chiu CL; Fang M; Huang F; Bhalla A; Llapashtica C; Prorok R; Pizzo ME; Calvert MEK; Sun EW; Hsiao-Nakamoto J; Rajendra Y; Lexa KW; Srivastava DB; van Lengerich B; Wang J; Robles-Colmenares Y; Kim DJ; Duque J; Lenser M; Earr TK; Nguyen H; Chau R; Tsogtbaatar B; Ravi R; Skuja LL; Solanoy H; Rosen HJ; Boeve BF; Boxer AL; Heuer HW; Dennis MS; Kariolis MS; Monroe KM; Przybyla L; Sanchez PE; Meisner R; Diaz D; Henne KR; Watts RJ; Henry AG; Gunasekaran K; Astarita G; Suh JH; Lewcock JW; DeVos SL; Di Paolo G
    Cell; 2021 Sep; 184(18):4651-4668.e25. PubMed ID: 34450028
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
    Mohan S; Sampognaro PJ; Argouarch AR; Maynard JC; Welch M; Patwardhan A; Courtney EC; Zhang J; Mason A; Li KH; Huang EJ; Seeley WW; Miller BL; Burlingame A; Jacobson MP; Kao AW
    Mol Neurodegener; 2021 Aug; 16(1):51. PubMed ID: 34344440
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease.
    Chen Y; Jian J; Hettinghouse A; Zhao X; Setchell KDR; Sun Y; Liu CJ
    J Mol Med (Berl); 2018 Dec; 96(12):1359-1373. PubMed ID: 30341570
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
    Holler CJ; Taylor G; McEachin ZT; Deng Q; Watkins WJ; Hudson K; Easley CA; Hu WT; Hales CM; Rossoll W; Bassell GJ; Kukar T
    Mol Neurodegener; 2016 Jun; 11(1):46. PubMed ID: 27341800
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.
    Hasan S; Fernandopulle MS; Humble SW; Frankenfield AM; Li H; Prestil R; Johnson KR; Ryan BJ; Wade-Martins R; Ward ME; Hao L
    Mol Neurodegener; 2023 Nov; 18(1):87. PubMed ID: 37974165
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia.
    Simon MJ; Logan T; DeVos SL; Di Paolo G
    Trends Cell Biol; 2023 Apr; 33(4):324-339. PubMed ID: 36244875
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Progranulin as a therapeutic target for dementia.
    Galimberti D; Fenoglio C; Scarpini E
    Expert Opin Ther Targets; 2018 Jul; 22(7):579-585. PubMed ID: 29889573
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
    Arrant AE; Onyilo VC; Unger DE; Roberson ED
    J Neurosci; 2018 Feb; 38(9):2341-2358. PubMed ID: 29378861
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
    Arrant AE; Roth JR; Boyle NR; Kashyap SN; Hoffmann MQ; Murchison CF; Ramos EM; Nana AL; Spina S; Grinberg LT; Miller BL; Seeley WW; Roberson ED
    Acta Neuropathol Commun; 2019 Dec; 7(1):218. PubMed ID: 31870439
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency.
    Tesla R; Guhl C; Werthmann GC; Dixon D; Cenik B; Addepalli Y; Liang J; Fass DM; Rosenthal Z; Haggarty SJ; Williams NS; Posner BA; Ready JM; Herz J
    Nat Commun; 2024 Jul; 15(1):6125. PubMed ID: 39033178
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
    Krabbe G; Minami SS; Etchegaray JI; Taneja P; Djukic B; Davalos D; Le D; Lo I; Zhan L; Reichert MC; Sayed F; Merlini M; Ward ME; Perry DC; Lee SE; Sias A; Parkhurst CN; Gan WB; Akassoglou K; Miller BL; Farese RV; Gan L
    Proc Natl Acad Sci U S A; 2017 May; 114(19):5029-5034. PubMed ID: 28438992
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
    Ward ME; Chen R; Huang HY; Ludwig C; Telpoukhovskaia M; Taubes A; Boudin H; Minami SS; Reichert M; Albrecht P; Gelfand JM; Cruz-Herranz A; Cordano C; Alavi MV; Leslie S; Seeley WW; Miller BL; Bigio E; Mesulam MM; Bogyo MS; Mackenzie IR; Staropoli JF; Cotman SL; Huang EJ; Gan L; Green AJ
    Sci Transl Med; 2017 Apr; 9(385):. PubMed ID: 28404863
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
    Martens LH; Zhang J; Barmada SJ; Zhou P; Kamiya S; Sun B; Min SW; Gan L; Finkbeiner S; Huang EJ; Farese RV
    J Clin Invest; 2012 Nov; 122(11):3955-9. PubMed ID: 23041626
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients.
    Arrant AE; Davis SE; Vollmer RM; Murchison CF; Mobley JA; Nana AL; Spina S; Grinberg LT; Karydas AM; Miller BL; Seeley WW; Roberson ED
    Ann Clin Transl Neurol; 2020 Dec; 7(12):2433-2449. PubMed ID: 33197149
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.