BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 36234686)

  • 1. Structure Activity Relationship Studies around
    Brahmaiah D; Bhavani AKD; Aparna P; Kumar NS; Solhi H; Le Guevel R; Baratte B; Robert T; Ruchaud S; Bach S; Jadav SS; Reddy CR; Mosset P; Gouault N; Levoin N; Grée R
    Molecules; 2022 Sep; 27(19):. PubMed ID: 36234686
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase.
    Brahmaiah D; Kanaka Durga Bhavani A; Aparna P; Sampath Kumar N; Solhi H; Le Guevel R; Baratte B; Ruchaud S; Bach S; Singh Jadav S; Raji Reddy C; Roisnel T; Mosset P; Levoin N; Grée R
    Bioorg Med Chem; 2021 Feb; 31():115962. PubMed ID: 33422908
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.
    ElHady AK; Abdel-Halim M; Abadi AH; Engel M
    J Med Chem; 2017 Jul; 60(13):5377-5391. PubMed ID: 28561591
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.
    Walter A; Chaikuad A; Helmer R; Loaëc N; Preu L; Ott I; Knapp S; Meijer L; Kunick C
    PLoS One; 2018; 13(5):e0196761. PubMed ID: 29723265
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).
    Mott BT; Tanega C; Shen M; Maloney DJ; Shinn P; Leister W; Marugan JJ; Inglese J; Austin CP; Misteli T; Auld DS; Thomas CJ
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6700-5. PubMed ID: 19837585
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.
    Falke H; Chaikuad A; Becker A; Loaëc N; Lozach O; Abu Jhaisha S; Becker W; Jones PG; Preu L; Baumann K; Knapp S; Meijer L; Kunick C
    J Med Chem; 2015 Apr; 58(7):3131-43. PubMed ID: 25730262
    [TBL] [Abstract][Full Text] [Related]  

  • 7. New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.
    Tazarki H; Zeinyeh W; Esvan YJ; Knapp S; Chatterjee D; Schröder M; Joerger AC; Khiari J; Josselin B; Baratte B; Bach S; Ruchaud S; Anizon F; Giraud F; Moreau P
    Eur J Med Chem; 2019 Mar; 166():304-317. PubMed ID: 30731399
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors.
    Lawson M; Rodrigo J; Baratte B; Robert T; Delehouzé C; Lozach O; Ruchaud S; Bach S; Brion JD; Alami M; Hamze A
    Eur J Med Chem; 2016 Nov; 123():105-114. PubMed ID: 27474927
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases.
    Lindberg MF; Deau E; Arfwedson J; George N; George P; Alfonso P; Corrionero A; Meijer L
    J Med Chem; 2023 Mar; 66(6):4106-4130. PubMed ID: 36876904
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives.
    Darwish SS; Abdel-Halim M; Salah M; Abadi AH; Becker W; Engel M
    Eur J Med Chem; 2018 Sep; 157():1031-1050. PubMed ID: 30193214
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel CLK1 inhibitors based on N-aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands.
    Murár M; Dobiaš J; Šramel P; Addová G; Hanquet G; Boháč A
    Eur J Med Chem; 2017 Jan; 126():754-761. PubMed ID: 27940419
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core.
    Ţînţaş ML; Peauger L; Alix F; Papamicaël C; Besson T; Sopková-de Oliveira Santos J; Gembus V; Levacher V
    Molecules; 2022 Dec; 28(1):. PubMed ID: 36615235
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.
    Bendjeddou LZ; Loaëc N; Villiers B; Prina E; Späth GF; Galons H; Meijer L; Oumata N
    Eur J Med Chem; 2017 Jan; 125():696-709. PubMed ID: 27721154
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, Synthesis, In Vitro Anti-cancer Activity, ADMET Profile and Molecular Docking of Novel Triazolo[3,4-a]phthalazine Derivatives Targeting VEGFR-2 Enzyme.
    El-Helby AA; Sakr H; Ayyad RRA; El-Adl K; Ali MM; Khedr F
    Anticancer Agents Med Chem; 2018; 18(8):1184-1196. PubMed ID: 29651967
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.
    Henderson SH; Sorrell FJ; Bennett JM; Fedorov O; Hanley MT; Godoi PH; Ruela de Sousa R; Robinson S; Navratilova IH; Elkins JM; Ward SE
    Eur J Med Chem; 2024 Apr; 269():116292. PubMed ID: 38479168
    [TBL] [Abstract][Full Text] [Related]  

  • 16. SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4.
    Tiek D; Wells CI; Schröder M; Song X; Alamillo-Ferrer C; Goenka A; Iglesia R; Lu M; Hu B; Kwarcinski F; Sintha P; de Silva C; Hossain MA; Picado A; Zuercher W; Zutshi R; Knapp S; Riggins RB; Cheng SY; Drewry DH
    Curr Res Chem Biol; 2023; 3():. PubMed ID: 38009092
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors.
    Schmitt C; Kail D; Mariano M; Empting M; Weber N; Paul T; Hartmann RW; Engel M
    PLoS One; 2014; 9(3):e87851. PubMed ID: 24676346
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening.
    Walter A; Chaikuad A; Loaëc N; Preu L; Knapp S; Meijer L; Kunick C; Koch O
    Mol Inform; 2017 Apr; 36(4):. PubMed ID: 28000414
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease.
    Jain P; Karthikeyan C; Moorthy NS; Waiker DK; Jain AK; Trivedi P
    Curr Drug Targets; 2014 May; 15(5):539-50. PubMed ID: 24568585
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity.
    Kumar K; Man-Un Ung P; Wang P; Wang H; Li H; Andrews MK; Stewart AF; Schlessinger A; DeVita RJ
    Eur J Med Chem; 2018 Sep; 157():1005-1016. PubMed ID: 30170319
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.