BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

246 related articles for article (PubMed ID: 36261424)

  • 1. Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications.
    Iannielli A; Luoni M; Giannelli SG; Ferese R; Ordazzo G; Fossati M; Raimondi A; Opazo F; Corti O; Prehn JHM; Gambardella S; Melki R; Broccoli V
    Cell Death Dis; 2022 Oct; 13(10):881. PubMed ID: 36261424
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.
    Zambon F; Cherubini M; Fernandes HJR; Lang C; Ryan BJ; Volpato V; Bengoa-Vergniory N; Vingill S; Attar M; Booth HDE; Haenseler W; Vowles J; Bowden R; Webber C; Cowley SA; Wade-Martins R
    Hum Mol Genet; 2019 Jun; 28(12):2001-2013. PubMed ID: 30753527
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.
    Fukusumi H; Togo K; Sumida M; Nakamori M; Obika S; Baba K; Shofuda T; Ito D; Okano H; Mochizuki H; Kanemura Y
    FEBS Open Bio; 2021 Feb; 11(2):354-366. PubMed ID: 33301617
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson's Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology.
    Diao X; Wang F; Becerra-Calixto A; Soto C; Mukherjee A
    Cells; 2021 Sep; 10(9):. PubMed ID: 34572052
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.
    Chen Y; Dolt KS; Kriek M; Baker T; Downey P; Drummond NJ; Canham MA; Natalwala A; Rosser S; Kunath T
    Eur J Neurosci; 2019 Feb; 49(4):510-524. PubMed ID: 30472757
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Isogenic human SNCA gene dosage induced pluripotent stem cells to model Parkinson's disease.
    Zafar F; Nallur Srinivasaraghavan V; Yang Chen M; Alejandra Morato Torres C; Schüle B
    Stem Cell Res; 2022 Apr; 60():102733. PubMed ID: 35263701
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease.
    Jimenez-Ferrer I; Bäckström F; Dueñas-Rey A; Jewett M; Boza-Serrano A; Luk KC; Deierborg T; Swanberg M
    Brain Behav Immun; 2021 Jan; 91():369-382. PubMed ID: 33223048
    [TBL] [Abstract][Full Text] [Related]  

  • 8. CRISPR-Cas9-Edited SNCA Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity.
    Inoue S; Nishimura K; Gima S; Nakano M; Takata K
    Biol Pharm Bull; 2023; 46(3):517-522. PubMed ID: 36858582
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Modeling Parkinson's disease using induced pluripotent stem cells.
    Byers B; Lee HL; Reijo Pera R
    Curr Neurol Neurosci Rep; 2012 Jun; 12(3):237-42. PubMed ID: 22538490
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.
    Flierl A; Oliveira LM; Falomir-Lockhart LJ; Mak SK; Hesley J; Soldner F; Arndt-Jovin DJ; Jaenisch R; Langston JW; Jovin TM; Schüle B
    PLoS One; 2014; 9(11):e112413. PubMed ID: 25390032
    [TBL] [Abstract][Full Text] [Related]  

  • 11. High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification.
    Vuidel A; Cousin L; Weykopf B; Haupt S; Hanifehlou Z; Wiest-Daesslé N; Segschneider M; Lee J; Kwon YJ; Peitz M; Ogier A; Brino L; Brüstle O; Sommer P; Wilbertz JH
    Stem Cell Reports; 2022 Oct; 17(10):2349-2364. PubMed ID: 36179692
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.
    Heman-Ackah SM; Manzano R; Hoozemans JJM; Scheper W; Flynn R; Haerty W; Cowley SA; Bassett AR; Wood MJA
    Hum Mol Genet; 2017 Nov; 26(22):4441-4450. PubMed ID: 28973645
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation.
    Pedrini M; Iannielli A; Meneghelli L; Passarella D; Broccoli V; Seneci P
    Pharmaceutics; 2023 May; 15(5):. PubMed ID: 37242709
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sex and Age Differences in a Progressive Synucleinopathy Mouse Model.
    Lamontagne-Proulx J; Coulombe K; Morissette M; Rieux M; Calon F; Di Paolo T; Soulet D
    Biomolecules; 2023 Jun; 13(6):. PubMed ID: 37371557
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson's disease patient-derived iPSCs.
    Patikas N; Ansari R; Metzakopian E
    Neurosci Res; 2023 Oct; 195():13-28. PubMed ID: 37271312
    [TBL] [Abstract][Full Text] [Related]  

  • 16. SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.
    Byers B; Cord B; Nguyen HN; Schüle B; Fenno L; Lee PC; Deisseroth K; Langston JW; Pera RR; Palmer TD
    PLoS One; 2011; 6(11):e26159. PubMed ID: 22110584
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
    Prieto Huarcaya S; Drobny A; Marques ARA; Di Spiezio A; Dobert JP; Balta D; Werner C; Rizo T; Gallwitz L; Bub S; Stojkovska I; Belur NR; Fogh J; Mazzulli JR; Xiang W; Fulzele A; Dejung M; Sauer M; Winner B; Rose-John S; Arnold P; Saftig P; Zunke F
    Autophagy; 2022 May; 18(5):1127-1151. PubMed ID: 35287553
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.
    Devine MJ; Ryten M; Vodicka P; Thomson AJ; Burdon T; Houlden H; Cavaleri F; Nagano M; Drummond NJ; Taanman JW; Schapira AH; Gwinn K; Hardy J; Lewis PA; Kunath T
    Nat Commun; 2011 Aug; 2():440. PubMed ID: 21863007
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.
    Kantor B; Tagliafierro L; Gu J; Zamora ME; Ilich E; Grenier C; Huang ZY; Murphy S; Chiba-Falek O
    Mol Ther; 2018 Nov; 26(11):2638-2649. PubMed ID: 30266652
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson's disease.
    Yasuda T; Mochizuki H
    Apoptosis; 2010 Nov; 15(11):1312-21. PubMed ID: 20221696
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.